Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Clarisse Lejeune"'
Autor:
Hu Zhaoyu, Ali Al-Mourabit, Thanh Binh Nguyen, Carine Vergne, Clarisse Lejeune, Céline Ratinaud, Ludmila Ermolenko
Publikováno v:
Organic Letters
Organic Letters, American Chemical Society, 2014, 16 (3), pp.872-5. ⟨10.1021/ol4036177⟩
Organic Letters, American Chemical Society, 2014, 16 (3), pp.872-5. ⟨10.1021/ol4036177⟩
International audience; Oxidative nucleophilic addition of ethylenediamine and guanidine derivatives to pyrrole-amino acid diketopiperazines was shown to provide substituted 5,6-dihydro-2(1H)-piperazinones, quinoxalinones, and 2-aminoimidazolones. On
Autor:
Rachel Schiller, Jacob T. Bush, G Scozzafava, James Wickens, Ganesha Rai, Bryan T. Mott, Akane Kawamura, Anthony Tumber, Clarisse Lejeune, Mun Chiang Chan, Tzu-Lan Yeh, James S. O. McCullagh, Hwanho Choi, David J. Maloney, Christopher J. Schofield
Publikováno v:
ChemMedChem
Chemmedchem
Chemmedchem
The 2-oxoglutarate (2OG)-dependent Jumonji C domain (JmjC) family is the largest family of histone lysine demethylases. There is interest in developing small-molecule probes that modulate JmjC activity to investigate their biological roles. 5-Carboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1052dfdee934f6f0cda848f1ab26d89f
https://ora.ox.ac.uk/objects/uuid:cc2a3734-4a5d-4aa5-b621-f371f424091f
https://ora.ox.ac.uk/objects/uuid:cc2a3734-4a5d-4aa5-b621-f371f424091f
Autor:
Christopher J. Schofield, Jürgen Brem, Anne Makena, Sander S. van Berkel, James Spencer, Raymond J. Owens, Clarisse Lejeune, Ramya Salimraj, Anil Verma
Serine- and metallo-β-lactamases present a threat to the clinical use of nearly all β-lactam antibiotics, including penicillins, cephalosporins, and carbapenems. Efforts to develop metallo-β-lactamase (MBL) inhibitors require suitable screening pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68301a34a042ad2dbfa8c78efd7640d2
https://doi.org/10.1002/cmdc.201300350
https://doi.org/10.1002/cmdc.201300350
Autor:
Anthony Tumber, N.A. Burgess-Brown, Michael A. McDonough, Clarisse Lejeune, F. von Delft, Kar Kheng Yeoh, Paul Brennan, Brian D. Marsden, Xuan Shirley Li, T. Krojer, Mun Chiang Chan, S.S. Ng, Carina Gileadi, Grazyna Kochan, Anna M. Rydzik, Akane Kawamura, Robert J. Klose, M. Daniel, Claire Strain-Damerell, Louise J. Walport, Leung Ikh., K.H. Che, Udo Oppermann, Rasheduzzaman Chowdhury, Nathan R. Rose, Woon Ecy., Susanne Müller, Christopher J. Schofield, Richard J. Hopkinson, King Onf., James E. Dunford, Peter J. Ratcliffe
Publikováno v:
Journal of Medicinal Chemistry
The JmjC oxygenases catalyze the N-demethylation of N(ε)-methyl lysine residues in histones and are current therapeutic targets. A set of human 2-oxoglutarate analogues were screened using a unified assay platform for JmjC demethylases and related o
Autor:
Akane Kawamura, Nathan R. Rose, Udo Oppermann, Susanne Muller-Knapp, Christopher J. Schofield, Paul Brennan, T. Krojer, Peter J. Ratcliffe, Hwanho Choi, Louise J. Walport, Robert J. Klose, Michael A. McDonough, Anna M. Rydzik, Kar Kheng Yeoh, Xuan Shirley Li, Rasheduzzaman Chowdhury, Lars Folke Olsen, Wei Shen Aik, Richard J. Hopkinson, Eleanor A.L. Bagg, Mun Chiang Chan, Cyrille C. Thinnes, Ka Hing Che, Anthony Tumber, Clarisse Lejeune, Oliver N. King, Wyatt W. Yue, Jacob T. Bush, Clarence Yapp, S.S. Ng, Jan B. L. Kristensen
Publikováno v:
Chemical Science
2-Oxoglutarate and iron dependent oxygenases are therapeutic targets for human diseases. Using a representative 2OG oxygenase panel, we compare the inhibitory activities of 5-carboxy-8-hydroxyquinoline (IOX1) and 4-carboxy-8-hydroxyquinoline (4C8HQ)
Autor:
Clarisse Lejeune, Ludmila Ermolenko, Marie-Thérèse Martin, Hua Tian, Jerome Appenzeller, Ali Al-Mourabit
Publikováno v:
Journal of Natural Products
Journal of Natural Products, American Chemical Society, 2013, 76 (5), pp.903-8. ⟨10.1021/np400048r⟩
Journal of Natural Products, American Chemical Society, 2013, 76 (5), pp.903-8. ⟨10.1021/np400048r⟩
International audience; The first biomimetic homodimerization of oroidin and clathrodin was effected in the presence HMPA and diphosphonate salts, strong guanidinium and amide chelating agents. The intermolecular associations probably interfere with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34045632bed23c349698da1e5579b87
https://hal.archives-ouvertes.fr/hal-00856777
https://hal.archives-ouvertes.fr/hal-00856777
Autor:
Kar Kheng Yeoh, Clarisse Lejeune, Zhihong Zhang, Marina Demetriades, Eleanor A.L. Bagg, Muhammad K. K. Hamdan, Wei Shen Aik, Michael A. McDonough, Christopher J. Schofield
Publikováno v:
Journal of medicinal chemistry. 56(9)
The fat mass and obesity associated protein (FTO) is a potential target for anti-obesity medicines. FTO is a 2-oxoglutarate (2OG)-dependent N-methyl nucleic acid demethylase that acts on substrates including 3-methylthymidine, 3-methyluracil, and 6-m
Autor:
Tristan J. Smart, Christopher J. Schofield, Adam P. Hardy, Akane Kawamura, Clarisse Lejeune, Timothy D. W. Claridge, Ivanhoe K. H. Leung, Marina Demetriades, Andrea Szöllössi
Publikováno v:
Journal of Medicinal Chemistry
The human 2-oxoglutarate (2OG) dependent oxygenases belong to a family of structurally related enzymes that play important roles in many biological processes. We report that competition-based NMR methods, using 2OG as a reporter ligand, can be used f
Autor:
Sander S. van Berkel, Clarisse Lejeune, Anne Makena, Ramya Salimraj, James Spencer, Christopher J. Schofield, Jürgen Brem, Anil Verma, Raymond J. Owens
Publikováno v:
ChemMedChem. 8:1897-1897
Autor:
Jacob T. Bush, N. D. Pradeep Singh, Amit Basak, Baisakhee Saha, Clarisse Lejeune, Partha Sarathi Addy, Christopher J. Schofield, Amit Das
Publikováno v:
Chemical Communications. 49:1930
The synthesis of small molecule based 1,3,5-trisubstituted benzenes for photo-mediated capture of human carbonic anhydrase II with visualisation by fluorescence is described.