Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Clarisse Kayembe"'
Autor:
Danilo Fiore, Luca Vincenzo Cappelli, Paul Zumbo, Jude M. Phillips, Zhaoqi Liu, Shuhua Cheng, Liron Yoffe, Paola Ghione, Federica Di Maggio, Ahmet Dogan, Inna Khodos, Elisa de Stanchina, Joseph Casano, Clarisse Kayembe, Wayne Tam, Doron Betel, Robin Foa’, Leandro Cerchietti, Raul Rabadan, Steven Horwitz, David M. Weinstock, Giorgio Inghirami
Publikováno v:
Cancers, Vol 12, Iss 6, p 1603 (2020)
Breast implant-associated lymphoma (BIA-ALCL) has recently been recognized as an independent peripheral T-cell lymphoma (PTCL) entity. In this study, we generated the first BIA-ALCL patient-derived tumor xenograft (PDTX) model (IL89) and a matching c
Externí odkaz:
https://doaj.org/article/6958d3085d5c47fdba82781ea47c3692
Autor:
Luca Vincenzo Cappelli, Danilo Fiore, Jude M. Phillip, Liron Yoffe, Filomena Di Giacomo, William Chiu, Yang Hu, Clarisse Kayembe, Michael Ginsberg, Lorena Consolino, Jose Gabriel Barcia Duran, Nahuel Zamponi, Ari M. Melnick, Francesco Boccalatte, Wayne Tam, Olivier Elemento, Sabina Chiaretti, Anna Guarini, Robin Foà, Leandro Cerchietti, Shahin Rafii, Giorgio Inghirami
Publikováno v:
Blood.
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive and often incurable disease. To uncover therapeutic vulnerabilities, we first developed T-ALL patient–derived tumor xenografts (PDXs) and exposed PDX cells to a library of 433 clinical-st
Autor:
Luca Vincenzo Cappelli, Clarisse Kayembe, Danilo Fiore, Giorgio Inghirami, Wayne Tam, Pedro Toruno, Maria Teresa Cacciapuoti
In the hemato-oncology field, remarkable scientific progress has been achieved, primarily propelled by the discovery of new technologies, improvement in genomics, and novel in vitro and in vivo models. The establishment of multiple cell line collecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e362aaa8803ace0b1c69145399648d1
http://hdl.handle.net/11588/874589
http://hdl.handle.net/11588/874589
Autor:
Robin Foà, Ahmet Dogan, Luca Vincenzo Cappelli, Steven M. Horwitz, Joseph Casano, Jude M Phillips, Paul Zumbo, Danilo Fiore, Liron Yoffe, David M. Weinstock, Leandro Cerchietti, Clarisse Kayembe, Federica Di Maggio, Elisa de Stanchina, Paola Ghione, Raul Rabadan, Zhaoqi Liu, Giorgio Inghirami, Wayne Tam, Inna Khodos, Shuhua Cheng, Doron Betel
Publikováno v:
Cancers
Volume 12
Issue 6
Cancers, Vol 12, Iss 1603, p 1603 (2020)
Volume 12
Issue 6
Cancers, Vol 12, Iss 1603, p 1603 (2020)
Breast implant-associated lymphoma (BIA-ALCL) has recently been recognized as an independent peripheral T-cell lymphoma (PTCL) entity. In this study, we generated the first BIA-ALCL patient-derived tumor xenograft (PDTX) model (IL89) and a matching c
Autor:
Lorena Consolino, Leandro Cerchietti, Sabina Chiaretti, Shahin Rafii, Francesco Boccalatte, Robin Foà, Yang Hu, Luca Vincenzo Cappelli, Filomena Di Giacomo, Michael Ginsberg, Olivier Elemento, Ari Melnick, Liron Yoffe, Wayne Tam, Danilo Fiore, Giorgio Inghirami, Nahuel Zamponi, Clarisse Kayembe, Jude M. Phillip, José Gabriel Barcia Durán, Anna Guarini
Publikováno v:
Blood. 138:704-704
Background. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with few innovative treatment options. This is also contributed by the lack of models capable of capturing the complexity of the tumor and its microenvironment. Aims. To
Autor:
Rui Wang, Rahul Karnik, Paul Zumbo, Olivier Elemento, Phillip Liu, Aristotelis Tsirigos, Giuseppina Astone, Doron Betel, Javier Rodriguez Hernaez, Akanksha Verma, Giorgio Inghirami, Michela Cumerlato, Luca Vincenzo Cappelli, Kirti Sharma, Liron Yoffe, Lara Brambilla, Jared Gollob, Steven M. Horwitz, Roberto Piva, Chris DeSavi, Joyoti Dey, David E. Levy, William Chiu, Francesco Boccalatte, Bin Yang, Clarisse Kayembe, Zachary D. Epstein-Peterson
Publikováno v:
Blood. 138:865-865
Introduction: Peripheral T-cell lymphomas (PTCLs) include heterogeneous entities of rare and aggressive neoplasms. The improved understanding of the biological/molecular mechanisms driving T-cell transformation and tumor maintenance has powerfully pr
Autor:
Luca Vincenzo Cappelli, Giuseppina Astone, Giorgio Inghirami, Wayne Tam, William Chiu, Maria Teresa Cacciapuoti, Giorgia Zanetti, Joseph M. Scandura, Lisa Giulino Roth, Danilo Fiore, Clarisse Kayembe, Lorenzo Galluzzi, Silvana Di Giandomenico
Publikováno v:
Blood. 138:2406-2406
Introduction: Immunotherapy is a promising therapeutic intervention for cancer treatment. Activation of the immune system via checkpoint blockade has been shown to produce antitumor responses in patients with both solid and hematological tumors. Howe
Autor:
Stephen J. Forman, Wesley A. Cheng, Fan Fei, Miriam Walter, Zhenyuan Dong, Luisa Sarno, Han Sun, Jianming Xie, Ibrahim Aldoss, Guowei Wei, Weili Xue, Xiuhua Sun, Joo Y. Song, Xiuli Wang, Feng Wen, Clarisse Kayembe, Chun-Wei Chen, Larry W. Kwak, D. Lynne Smith, Hong Qin, Giorgio Inghirami, Theano I. Panagopoulou, Markus Müschen
Publikováno v:
Science translational medicine. 11(511)
CAR T cells targeting CD19 provide promising options for treatment of B cell malignancies. However, tumor relapse from antigen loss can limit efficacy. We developed humanized, second-generation CAR T cells against another B cell–specific marker, B
Autor:
María Sánchez-Díaz, Heinrich Schrewe, Jasper Mullenders, Markus Schober, Leonela Amoasii, Iannis Aifantis, Ramya Raviram, Stephanie Lau, Maria Guillamot, Pedro P. Rocha, Beatriz Aranda-Orgilles, Avik Choudhuri, Ricardo Saldaña-Meyer, Eirini Trompouki, Eric Wang, Aristotelis Tsirigos, Jane A. Skok, Kun Wang, Leonard I. Zon, Anne Fassl, Nan Zhang, Danny Reinberg, Piotr Sicinski, Clarisse Kayembe
Publikováno v:
Cell Stem Cell
Hematopoietic-specific transcription factors require coactivators to communicate with the general transcription machinery and establish transcriptional programs that maintain hematopoietic stem cell (HSC) self-renewal, promote differentiation, and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe77e3d89e8ccee1fbb37099beeba41c
https://hdl.handle.net/11858/00-001M-0000-002C-A8BC-C
https://hdl.handle.net/11858/00-001M-0000-002C-A8BC-C
Autor:
Charalampos Lazaris, Francesco Boccalatte, Kelly Moran-Crusio, Elmar Wolf, Beatriz Aranda-Orgilles, Iannis Aifantis, Xiaofeng Yu, Clarisse Kayembe, Anna Lasorella, Bryan W. King, Jingjing Wang
Publikováno v:
Nature immunology
Hematopoietic stem cells (HSCs) are dormant in the bone marrow and can be activated in response to diverse stresses to replenish all blood cell types. We identified the ubiquitin ligase Huwe1 as a crucial regulator of HSC function via its post-transl