Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Clarisse G Ricci"'
Autor:
Jonathan M Philpott, Rajesh Narasimamurthy, Clarisse G Ricci, Alfred M Freeberg, Sabrina R Hunt, Lauren E Yee, Rebecca S Pelofsky, Sarvind Tripathi, David M Virshup, Carrie L Partch
Publikováno v:
eLife, Vol 9 (2020)
Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation of CK1 in eukaryotes, little is known about its regulation and the
Externí odkaz:
https://doaj.org/article/b24fcf56b8e544f2a439eb2d0a4668d5
Autor:
Clarisse G. Ricci, Janice S. Chen, Yinglong Miao, Martin Jinek, Jennifer A. Doudna, J. Andrew McCammon, Giulia Palermo
Publikováno v:
ACS Central Science, Vol 5, Iss 4, Pp 651-662 (2019)
Externí odkaz:
https://doaj.org/article/081cc12949eb4f1ea40fa9fbc42575d1
Publikováno v:
J Chem Theory Comput
Journal of chemical theory and computation, vol 17, iss 4
Journal of chemical theory and computation, vol 17, iss 4
We develop a hybrid approach that combines the Monte Carlo (MC) method, a variational implicit-solvent model (VISM), and a binary level-set method for the simulation of biomolecular binding in an aqueous solvent. The solvation free energy for the bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c012d22ffaab6df21ea900b7d4cde152
https://doi.org/10.1021/acs.jctc.0c01109
https://doi.org/10.1021/acs.jctc.0c01109
Autor:
Jonathan M. Philpott, Alfred M. Freeberg, Jiyoung Park, Kwangjun Lee, Clarisse G. Ricci, Sabrina R. Hunt, Rajesh Narasimamurthy, David H. Segal, Rafael Robles, Yao D. Cai, Sarvind Tripathi, J. Andrew McCammon, David M. Virshup, Joanna C. Chiu, Choogon Lee, Carrie L. Partch
SummaryPERIOD (PER) and Casein Kinase 1δ regulate circadian rhythms through a phosphoswitch that controls PER stability and repressive activity in the molecular clock. CK1δ phosphorylation of the Familial Advanced Sleep Phase (FASP) serine cluster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8a0e1e124ec9300d90b9cc108c2814
https://doi.org/10.1101/2022.06.24.497549
https://doi.org/10.1101/2022.06.24.497549
Autor:
Rajesh Narasimamurthy, Jonathan M. Philpott, Rebecca S. Pelofsky, Alfred M. Freeberg, Sarvind Tripathi, Carrie L. Partch, Clarisse G. Ricci, Lauren E. Yee, David M. Virshup, Sabrina R. Hunt
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation of CK1 in eukaryotes, little is known about its regulation and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115bb948599601d2bbb2e2f0d28b925f
https://doi.org/10.7554/elife.52343
https://doi.org/10.7554/elife.52343
Publikováno v:
The Journal of Physical Chemistry B. 122:11695-11701
Water, despite being a driving force in biochemical processes, has an elusively complex microscopic behavior. While water can increase its local density near amphiphilic protein surfaces, water is also thought to evaporate from hydrophobic surfaces a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86248fd8121d5e9a105f77c902934625
https://doi.org/10.1021/acs.jpcb.8b07773
https://doi.org/10.1021/acs.jpcb.8b07773
Autor:
Carrie L. Partch, Lauren E. Yee, Rebecca S. Pelofsky, Clarisse G. Ricci, Rajesh Narasimamurthy, Sarvind Tripathi, Alfred M. Freeberg, Jonathan M. Philpott, David M. Virshup, Sabrina R. Hunt
Publikováno v:
Biophysical Journal. 118:207a-208a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b25230307fce3f9d419fb253d705bb36
https://doi.org/10.1016/j.bpj.2019.11.1243
https://doi.org/10.1016/j.bpj.2019.11.1243
Autor:
Sarvind Tripathi, Rebecca S. Pelofsky, Clarisse G. Ricci, Rajesh Narasimamurthy, Carrie L. Partch, Alfred M. Freeberg, Jonathan M. Philpott, Lauren E. Yee, David M. Virshup, Sabrina R. Hunt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d4cbefad3dbd8755f9dd20323c7af4
https://doi.org/10.7554/elife.52343.sa2
https://doi.org/10.7554/elife.52343.sa2
Autor:
J. Andrew McCammon, Yinglong Miao, Jennifer A. Doudna, Martin Jinek, Clarisse G. Ricci, Giulia Palermo, Janice S. Chen
Publikováno v:
ACS central science, vol 5, iss 4
ACS Central Science, Vol 5, Iss 4, Pp 651-662 (2019)
ACS Central Science, Vol 5, Iss 4, Pp 651-662 (2019)
[Image: see text] CRISPR-Cas9 is the state-of-the-art technology for editing and manipulating nucleic acids. However, the occurrence of off-target mutations can limit its applicability. Here, all-atom enhanced molecular dynamics (MD) simulations—us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954abb7ea5eca3a651df86f643475ffc
https://www.zora.uzh.ch/id/eprint/174103/
https://www.zora.uzh.ch/id/eprint/174103/
Publikováno v:
Physics today, vol 72, iss 4
Since the discovery of the DNA double helix, the main molecular repository of genetic information, scientists have been struggling to find ways to efficiently manipulate genes. The ability to mark, modify, or regulate specific sequences of DNA in a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f5633dfc7f6a5fe0b257aa8fd2c4a260
https://escholarship.org/uc/item/7rx5m1d9
https://escholarship.org/uc/item/7rx5m1d9