Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Clarissa von Haefen"'
Autor:
Charlotte Middel, Matthias Stetzuhn, Nadine Sander, Björn Kalkbrenner, Timo Tigges, Alexandru-Gabriel Pielmus, Claudia Spies, Klaus Pietzner, Michael Klum, Clarissa von Haefen, Oliver Hunsicker, Jalid Sehouli, Frank Konietschke, Aarne Feldheiser
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-11 (2023)
Abstract Background Patients undergoing high-risk surgery show haemodynamic instability and an increased risk of morbidity. However, most of the available data concentrate on the intraoperative period. This study aims to characterise patients with ad
Externí odkaz:
https://doaj.org/article/75c449e03a534790a9a17043148a6616
Autor:
Yanite Jacob, Bill Schneider, Claudia Spies, Maria Heinrich, Clarissa von Haefen, Widuri Kho, Anne Pohrt, Anika Müller
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Dexmedetomidine is an alpha-2 adrenoreceptor agonist with anti-inflammatory and anti-delirogenic properties. Pathogenesis of postoperative delirium (POD) includes cholinergic dysfunction and deregulated inflammatory response to surgical trau
Externí odkaz:
https://doaj.org/article/ac4add47211549e9850ce2dc5db42c54
Autor:
Claudia Spies, Gunnar Lachmann, Clarissa von Haefen, Erika Schulte, Anna Dorothea Kuhlmann, Maximilian Jara, Mandy Mertens, Laura Anouk Süß, Nathalie Winkler, Cornelia Lachmann
Publikováno v:
BMJ Open, Vol 13, Iss 5 (2023)
Objectives Preoperative hypoalbuminaemia is associated with adverse outcome, including increased postoperative mortality in cardiovascular surgery, neurosurgery, trauma and orthopaedic surgery. However, much less is known about the association betwee
Externí odkaz:
https://doaj.org/article/6d663b1f1a5c4ed993faae347cee14ba
Publikováno v:
Antioxidants, Vol 12, Iss 6, p 1206 (2023)
Preterm birth is a risk factor for cardiometabolic disease. The preterm heart before terminal differentiation is in a phase that is crucial for the number and structure of cardiomyocytes in further development, with adverse effects of hypoxic and hyp
Externí odkaz:
https://doaj.org/article/83959074705041f7a93c9172fb95ee3d
Autor:
Gunnar Lachmann, Bharath Ananthasubramaniam, Viktor A. Wünsch, Lara-Marie Scherfig, Clarissa von Haefen, Cornelia Knaak, Andreas Edel, Lukas Ehlen, Barbara Koller, Anton Goldmann, Hanspeter Herzel, Achim Kramer, Claudia Spies
Publikováno v:
Annals of Intensive Care, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Background Despite the intensive efforts to improve the diagnosis and therapy of sepsis over the last decade, the mortality of septic shock remains high and causes substantial socioeconomical burden of disease. The function of immune cells i
Externí odkaz:
https://doaj.org/article/885495e07c604438b0109ea0f9023e30
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7804 (2023)
The risk of oxidative stress is unavoidable in preterm infants and increases the risk of neonatal morbidities. Premature infants often require sedation and analgesia, and the commonly used opioids and benzodiazepines are associated with adverse effec
Externí odkaz:
https://doaj.org/article/2005d07a689c4f0faa33dc3628b90aba
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 980 (2023)
Impaired cerebellar development of premature infants and the associated impairment of cerebellar functions in cognitive development could be crucial factors for neurodevelopmental disorders. Anesthetic- and hyperoxia-induced neurotoxicity of the imma
Externí odkaz:
https://doaj.org/article/c1034658866f491b894685a6d0b4cbdc
Autor:
Nadine Lanzke, Mario Menk, Clarissa von Haefen, Lilit Sargsyan, Bianca Scharf, Klaus-Dieter Wernecke, Claudia D. Spies
Publikováno v:
International Journal of Inflammation, Vol 2017 (2017)
Background. Interactions between alcohol, infection, and surgery and their effect on differentiation and functionality of T helper cells are not yet completely understood. We hypothesized that alcohol and surgery disturb differentiation of T helper c
Externí odkaz:
https://doaj.org/article/a1c34bf4674145979d67cc8aeba54a4d
Autor:
Stefanie Endesfelder, Hanan Makki, Clarissa von Haefen, Claudia D Spies, Christoph Bührer, Marco Sifringer
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171498 (2017)
Dexmedetomidine (DEX) is a highly selective agonist of α2-receptors with sedative, anxiolytic, and analgesic properties. Neuroprotective effects of dexmedetomidine have been reported in various brain injury models. In the present study, we investiga
Externí odkaz:
https://doaj.org/article/415b2047976d44a5b2faa02d09672534
Autor:
Ivo Bendix, Meray Serdar, Josephine Herz, Clarissa von Haefen, Fatme Nasser, Benjamin Rohrer, Stefanie Endesfelder, Ursula Felderhoff-Mueser, Claudia D. Spies, Marco Sifringer
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 3, Pp 3784-3798 (2014)
Exposure to N-methyl-d-aspartate (NMDA) receptor antagonists has been demonstrated to induce neurodegeneration in newborn rats. However, in clinical practice the use of NMDA receptor antagonists as anesthetics and sedatives cannot always be avoided.
Externí odkaz:
https://doaj.org/article/c0cc5a957f164be6bc01db1553dfb473