Výsledky vyhledávání - "Clarissa R. Zaitune"

Akademický článek

Abnormal Thyroid Hormone Status Differentially Affects Bone Mass Accrual and Bone Strength in C3H/HeJ Mice: A Mouse Model of Type I Deiodinase Deficiency

Autor: Clarissa R. Zaitune, Tatiana L. Fonseca, Luciane P. Capelo, Fatima R. Freitas, Eduardo H. Beber, José M. Dora, Charles C. Wang, Manuela Miranda-Rodrigues, Keico O. Nonaka, Ana L. Maia, Cecilia H. A. Gouveia

Publikováno v: Frontiers in Endocrinology, Vol 10 (2019)

C3H/HeJ (C3H) mice are deficient of type I deiodinase (D1), an enzyme that activates thyroid hormone (TH), converting thyroxine (T4) to triiodothyronine (T3). Nevertheless, C3H mice present normal serum T3 and a gross euthyroid phenotype. To investig

Externí odkaz: https://doaj.org/article/df5008aa1e0c46a7bd494380dca4c590

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Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation

Autor: Clarissa R Zaitune, Cecilia H. A. Gouveia, Marcelo A. Christoffolete, Antonio C. Bianco, Ana Luiza Maia, John W. Harney, José Miguel Dora

Publikováno v: Endocrinology. 146(1)

Thyroid hormone affects multiple aspects of bone metabolism, but little is known about thyroid hormone deiodination in bone cells except that cultures of skeletal cells and bone organ express types 1 and 2 iodothyronine deiodinases (D1 and D2) mRNAs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f364603369eedbb3c9a8139cdd48dab4
https://pubmed.ncbi.nlm.nih.gov/15471965

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