Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Clarissa M. Czekster"'
Autor:
Dillum Patel, Alison L. Dickson, Greice M. Zickuhr, In Hwa Um, Oliver J. Read, Clarissa M. Czekster, Peter Mullen, David J. Harrison, Jennifer Bré
Publikováno v:
Translational Oncology, Vol 50, Iss , Pp 102114- (2024)
The combination of gemcitabine with platinum agents is a widely used chemotherapy regimen for a number of tumour types. Gemcitabine plus cisplatin remains the current therapeutic choice for biliary tract cancer. Gemcitabine is associated with multipl
Externí odkaz:
https://doaj.org/article/c3c62a6cd41e4e5e96928c106ddb18b1
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Cyclic peptide macrocycles are promising anti-cancer and antimicrobial molecules. Here, the authors characterize the structure and catalytic mechanism of the prolyl oligopeptidase B from Basidiomycete fungi, showing that its dual macrocyclase-peptida
Externí odkaz:
https://doaj.org/article/6dc005fce7cd4bbe952d36cff3418252
Autor:
Gemma Fisher, Ennio Pečaver, Benjamin J. Read, Susannah K. Leese, Erin Laing, Alison L. Dickson, Clarissa M. Czekster, Rafael G. da Silva
Publikováno v:
ACS Catalysis. :7669-7679
Funding: This study was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) (Grant BB/M010996/1) via EASTBIO Doctoral Training Partnership studentships to G.F. and B.J.R., and by the University of St Andrews via a StARIS s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81ad870b3ab2d2405557b3295b70f5f
https://doi.org/10.1021/acscatal.3c01111
https://doi.org/10.1021/acscatal.3c01111
Autor:
Jennifer Bré, Alison L. Dickson, Oliver J. Read, Ying Zhang, Fiona G. McKissock, Peter Mullen, Peijun Tang, Greice M. Zickuhr, Clarissa M. Czekster, David J. Harrison
Publikováno v:
Cancer Chemotherapy and Pharmacology. 91:401-412
Introduction Fluoropyrimidines, principally 5-fluorouracil (5-FU), remain a key component of chemotherapy regimens for multiple cancer types, in particular colorectal and other gastrointestinal malignancies. To overcome key limitations and pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d806fb950ffd20e09ec9f1c3ba63c442
https://doi.org/10.1007/s00280-023-04528-5
https://doi.org/10.1007/s00280-023-04528-5
Autor:
Januka S Athukoralage, Shirley Graham, Christophe Rouillon, Sabine Grüschow, Clarissa M Czekster, Malcolm F White
Publikováno v:
eLife, Vol 9 (2020)
Cyclic nucleotide second messengers are increasingly implicated in prokaryotic anti-viral defence systems. Type III CRISPR systems synthesise cyclic oligoadenylate (cOA) upon detecting foreign RNA, activating ancillary nucleases that can be toxic to
Externí odkaz:
https://doaj.org/article/afca9bf979b645389754febb33d49a97
Autor:
Pamela Sweeney, Ashleigh Galliford, Abhishek Kumar, Dinesh Raju, Naveen B. Krishna, Emmajay Sutherland, Caitlin J. Leo, Gemma Fisher, Roopa Lalitha, Likith Muthuraj, Gladstone Sigamani, Verena Oehler, Silvia Synowsky, Sally L. Shirran, Tracey M. Gloster, Clarissa M. Czekster, Pravin Kumar, Rafael G. da Silva
This work was supported by a Wellcome Trust Seed Award in Science [208980/Z/17/Z] to RGdS; a University of St Andrews/Scottish Funding Council St Andrews Restarting Research Fund to RGdS; and a Wellcome Trust Institutional Strategic Support Fund [204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08da56da0a5a8e7b1fd74ba9111e89f5
https://hdl.handle.net/10023/25512
https://hdl.handle.net/10023/25512
Autor:
Pamela, Sweeney, Ashleigh, Galliford, Abhishek, Kumar, Dinesh, Raju, Naveen B, Krishna, Emmajay, Sutherland, Caitlin J, Leo, Gemma, Fisher, Roopa, Lalitha, Likith, Muthuraj, Gladstone, Sigamani, Verena, Oehler, Silvia, Synowsky, Sally L, Shirran, Tracey M, Gloster, Clarissa M, Czekster, Pravin, Kumar, Rafael G, da Silva
Publikováno v:
The Journal of biological chemistry. 298(6)
The enzyme m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3aaa8b75766f3646e36ccf88f5c99670
https://pubmed.ncbi.nlm.nih.gov/35595101
https://pubmed.ncbi.nlm.nih.gov/35595101
Autor:
Pamela Sweeney, Ashleigh Crowe, Abhishek Kumar, Dinesh Raju, Naveen B. Krishna, Emmajay Sutherland, Caitlin J. Leo, Gemma Fisher, Roopa Lalitha, Likith Muthuraj, Gladstone Sigamani, Verena Oehler, Silvia Synowsky, Sally L. Shirran, Tracey M. Gloster, Clarissa M. Czekster, Pravin Kumar, Rafael G. da Silva
The enzyme m1A22-tRNA methyltransferase (TrmK) catalyses the transfer of a methyl group from SAM to the N1 of adenine 22 in tRNAs. TrmK is essential for Staphylococcus aureus survival during infection, but has no homologue in mammals, making it a pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6952c89b3e51b9b8d47024c86f7520b6
https://doi.org/10.1101/2021.12.24.474102
https://doi.org/10.1101/2021.12.24.474102
Cyclodipeptide synthases (CDPSs) are a growing family of enzymes capable of producing a large variety of cyclodipetide products using aminoacylated tRNA. Histidine-containing cyclic dipeptides have important biological activities as anticancer and ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9a5c92b28309a3b065a3cd362d987fe
https://doi.org/10.26434/chemrxiv-2021-8rm54
https://doi.org/10.26434/chemrxiv-2021-8rm54
Autor:
Jennifer Bré, Alison L. Dickson, Oliver J. Read, Ying Zhang, Clarissa M. Czekster, David J. Harrison
Publikováno v:
Cancer Research. 82:1835-1835
Background: Over the past 60 years, numerous strategies have been employed to enhance the generation of the anticancer metabolite FUDR-MP (FdUMP) by 5-FU and to reduce the generation of toxic metabolites. FUDR-MP, the primary anticancer metabolite of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47e785b6c1412199196547c24037c67f
https://doi.org/10.1158/1538-7445.am2022-1835
https://doi.org/10.1158/1538-7445.am2022-1835