Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Clarissa J. Watts"'
Autor:
Susan W Burriss, Susanne Wang, Paul P. Tak, Kurt Brown, Kathy Weisel, Matthijs Broer, Marcy Powell, Clarissa J. Watts, Kathy Abbott-Banner, Debra J. Tompson, Nicola Scott, Simon Hawkins, Scott B. Berger
Publikováno v:
BMJ Open Gastroenterology
BMJ Open Gastroenterology, Vol 8, Iss 1 (2021)
BMJ Open Gastroenterology, Vol 8, Iss 1 (2021)
ObjectiveTumour necrosis factor signalling via the receptor-interacting protein kinase 1 (RIPK1) pathway regulates colonic inflammation suggesting that RIPK1 inhibition may be a potential therapeutic target in ulcerative colitis (UC). This phase IIa,
Autor:
Kenneth L. Clark, Paul Martin Gore, Panayiotis A. Procopiou, Simon Teanby Hodgson, Alison J. Ford, Clarissa J. Watts, Robert J. Slack, Duncan S. Holmes, Brian Edgar Looker, Ken A. Saunders, Ashley Paul Hancock, Sadie Vile
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4914-4919
A series of potent, selective and long-acting quinoline-based sulfonamide human H1 histamine receptor antagonists, designed for once-daily intranasal administration for the treatment of rhinitis were developed. Sulfonamide 33b had a slightly lower af
Autor:
Robert J. Slack, Brian Edgar Looker, Sadie Vile, Duncan S. Holmes, Kenneth L. Clark, Clarissa J. Watts, Simon Teanby Hodgson, Panayiotis A. Procopiou, Paul Martin Gore, Ken A. Saunders, Alison J. Ford, James E. Rowedder
Publikováno v:
ACS Medicinal Chemistry Letters. 8:577-581
The synthesis of potent amide-containing phthalazinone H1 histamine receptor antagonists is described. Three analogues 3e, 3g, and 9g were equipotent with azelastine and were longer-acting in vitro. Amide 3g had low oral bioavailability, low brain-pe
Autor:
Panayiotis A, Procopiou, Alison J, Ford, Paul M, Gore, Ashley P, Hancock, Simon T, Hodgson, Duncan S, Holmes, Brian E, Looker, Sadie, Vile, Kenneth L, Clark, Ken A, Saunders, Robert J, Slack, Clarissa J, Watts
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(21)
A series of potent, selective and long-acting quinoline-based sulfonamide human H
Autor:
Panayiotis A, Procopiou, Alison J, Ford, Paul M, Gore, Brian E, Looker, Simon T, Hodgson, Duncan S, Holmes, Sadie, Vile, Kenneth L, Clark, Ken A, Saunders, Robert J, Slack, James E, Rowedder, Clarissa J, Watts
Publikováno v:
ACS medicinal chemistry letters. 8(5)
The synthesis of potent amide-containing phthalazinone H
Autor:
Robert J. Shaw, Matthew C. Catley, Kerryn McCluskie, Tony J. Savage, Jorge De Alba, Clarissa J. Watts, Robert Newton, Saleem Haj-Yahia, Maria G. Belvisi, K. Tao Pun, Sissie Wong, Mark A. Birrell, Elizabeth Hardaker
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 172:962-971
Rationale Nuclear factor (NF)-kappaB is a transcription factor known to regulate the expression of many inflammatory genes, including cytokines, chemokines, and adhesion molecules. NF-kappaB is held inactive in the cytoplasm, bound to I-kappaB. The r
Autor:
Linda J. Russell, Paul Martin Gore, Simon Teanby Hodgson, Ashley Paul Hancock, Robert J. Slack, Jennifer M. Buckley, Sadie Vile, Michael Kranz, Steven L. Sollis, Kenneth L. Clark, Brian Edgar Looker, Panayiotis A. Procopiou, Clarissa J. Watts, Duncan S. Holmes, Christopher Browning, Lise C. Fechner, Daniel L. Parton, Karen M. L. Morriss
Publikováno v:
Journal of medicinal chemistry. 54(7)
A series of potent phthalazinone-based human H(1) and H(3) bivalent histamine receptor antagonists, suitable for intranasal administration for the potential treatment of allergic rhinitis, were identified. Blockade of H(3) receptors is thought to imp
Autor:
Gemma Victoria White, Helen E. Connor, Elizabeth Pickup, David Matthew Wilson, Clarissa J. Watts, Christopher Browning, Sanjeet Singh Sehmi, Karen M. L. Morriss, Mark James Bamford, Christopher A. Parr, Susannah Davies, Brian Edgar Looker, Panayiotis A. Procopiou, Simon Teanby Hodgson, Fogden Yvonne C, Rachael A. Ancliff, Woodrow Michael David, Duncan S. Holmes
Publikováno v:
Journal of medicinal chemistry. 50(26)
A series of ketopiperazines were prepared and evaluated for their activity as histamine H 3 antagonists. From investigation of the tertiary basic center in the aminopropyloxyphenyl template, the 2( R)-methylpyrrolidine was identified as the most pote
Autor:
Panayiotis A. Procopiou, Rachael A. Ancliff, Mark J. Bamford, Christopher Browning, Helen Connor, Susannah Davies, Yvonne C. Fogden, Simon T. Hodgson, Duncan S. Holmes, Brian E. Looker, Karen M. L. Morriss, Christopher A. Parr, Elizabeth A. Pickup, Sanjeet S. Sehmi, Gemma V. White, Clarissa J. Watts, David M. Wilson, Michael D. Woodrow
Publikováno v:
Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 26, p6706-6717, 12p