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pro vyhledávání: '"Clarissa Herman"'
Autor:
Charleen Hunt, Suzanne A. Hartford, Derek White, Evangelos Pefanis, Timothy Hanna, Clarissa Herman, Jarrell Wiley, Heather Brown, Qi Su, Yurong Xin, Dennis Voronin, Hien Nguyen, Judith Altarejos, Keith Crosby, Jeffery Haines, Sarah Cancelarich, Meghan Drummond, Sven Moller-Tank, Ryan Malpass, Jacqueline Buckley, Maria del Pilar Molina-Portela, Gustavo Droguett, David Frendewey, Eric Chiao, Brian Zambrowicz, Guochun Gong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
CRISPR-Cas9 is a gene editing tool that can be used to modulate gene expression. Here, the authors report the generation of a mouse model that express all components of the CRISPR-Cas9 guide directed Synergistic Activation Mediator (SAM), demonstrate
Externí odkaz:
https://doaj.org/article/17fb14b41cbb4fa7890fbff2faf8ff19
Autor:
Jeffery Haines, Derek White, Maria del Pilar Molina-Portela, Brian Zambrowicz, Gustavo Droguett, Jarrell Wiley, Clarissa Herman, Timothy Hanna, Judith Altarejos, Hien Nguyen, Sven Moller-Tank, Qi Su, Heather Brown, Sarah Cancelarich, Dennis Voronin, Jacqueline Buckley, Evangelos Pefanis, Eric Chiao, Suzanne Hartford, David Frendewey, Meghan Drummond, Ryan Malpass, Keith Crosby, Charleen Hunt, Yurong Xin, Guochun Gong
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
CRISPR-based transcriptional activation is a powerful tool for functional gene interrogation; however, delivery difficulties have limited its applications in vivo. Here, we created a mouse model expressing all components of the CRISPR-Cas9 guide RNA-