Contribution of Leishmania braziliensis antigen-specific CD4+ T, CD8+ T, NK and CD3+CD56+NKT cells in the immunopathogenesis of cutaneous leishmaniasis patients: Cytotoxic, activation and exhaustion profiles.

Autor: Clarissa F Cunha, Raquel Ferraz-Nogueira, Vanessa F A Costa, Maria Inês F Pimentel, Thaize Q Chometon, Marcelo R Lyra, Armando O Schubach, Alda Maria Da-Cruz, Alvaro Luiz Bertho

Publikováno v: PLoS ONE, Vol 15, Iss 3, p e0229400 (2020)

The pathogenesis of cutaneous leishmaniasis (CL) caused by Leishmania (Viannia) braziliensis is dictated mainly by the immune-mediated-tissue inflammation developed. The understanding of the immunological mechanisms that generate tissue damage or res

Externí odkaz: https://doaj.org/article/248234f3a2654793b6133567b3990c38

Contribution of Leishmania braziliensis antigen-specific CD4+ T, CD8+ T, NK and CD3+CD56+NKT cells in the immunopathogenesis of cutaneous leishmaniasis patients: Cytotoxic, activation and exhaustion profiles

Autor: Vanessa F. A. Costa, Raquel Ferraz-Nogueira, Marcelo R. Lyra, Alda Maria Da-Cruz, Clarissa F. Cunha, Maria Inês Fernandes Pimentel, Álvaro Luiz Bertho, Armando de Oliveira Schubach, Thaize Quiroga Chometon

Publikováno v: PLoS ONE, Vol 15, Iss 3, p e0229400 (2020)
PLoS ONE

The pathogenesis of cutaneous leishmaniasis (CL) caused by Leishmania (Viannia) braziliensis is dictated mainly by the immune-mediated-tissue inflammation developed. The understanding of the immunological mechanisms that generate tissue damage or res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9fa2a14e7aca5432234c77da95afa1
https://doaj.org/article/248234f3a2654793b6133567b3990c38

Apical membrane protein 1‐specific antibody profile and temporal changes in peripheral blood B‐cell populations in Plasmodium vivax malaria

Autor: Rodrigo Nunes Rodrigues-da-Silva, Marcelo U. Ferreira, Alessandro Marins-Dos-Santos, Álvaro Luiz Bertho, Roberta Reis Soares, Josué da Costa Lima-Junior, Clarissa F. Cunha, Kézia K. G. Scopel, Raquel Ferraz-Nogueira, Irene S. Soares

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Plasmodium falciparum-specific antibodies tend to be short-lived, but their cognate memory B cells (MBCs) circulate in the peripheral blood of exposed subjects for several months or years after the last infection. However, the time course of antigen-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d884f31f76997928fbb3928c362d7c3

T-cell receptor Vβ repertoire of CD8+ T-lymphocyte subpopulations in cutaneous leishmaniasis patients from the state of Rio de Janeiro, Brazil

Autor: Marcelo Rosandiski Lyra, Maria Inês Fernandes Pimentel, Raquel Ferraz, Clarissa F. Cunha, S. C. F. Mendonça, Álvaro Luiz Bertho, Alda Maria Da-Cruz, Armando de Oliveira Schubach

Publikováno v: Memórias do Instituto Oswaldo Cruz., Vol 110, Iss 5, Pp 596-605 (2015)
Memórias do Instituto Oswaldo Cruz, Volume: 110, Issue: 5, Pages: 596-605, Published: 24 JUN 2015
Memórias do Instituto Oswaldo Cruz

In human cutaneous leishmaniasis (CL), the immune response is mainly mediated by T-cells. The role of CD8+ T-lymphocytes, which are related to healing or deleterious functions, in affecting clinical outcome is controversial. The aim of this study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04e285f5dc1cd7f6b0d96ff4be02ef5
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000500596&lng=en&tlng=en

Apoptosis and frequency of total and effector CD8+ T lymphocytes from cutaneous leishmaniasis patients during antimonial therapy

Autor: Adriano Gomes-Silva, Sergio C.F. Mendonça, Raquel Ferraz, Alda Maria Da-Cruz, Clarissa F. Cunha, Armando de Oliveira Schubach, Álvaro Luiz Bertho, Cláudia Maria Valete-Rosalino, Marcelo Rosandiski Lyra, Maria Inês Fernandes Pimentel

Publikováno v: BMC Infectious Diseases

Background Leishmaniasis is an important parasitic disease affecting millions worldwide. Human cutaneous leishmaniasis (CL) is endemic in Rio de Janeiro, Brazil, where is caused by Leishmania braziliensis. The adaptive immune response is accountable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac3863c0ca11d72addfbf46f5338bac