Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Clarissa C. Forneris"'
Autor:
Thomas A. Scott, Marjan Verest, Jakob Farnung, Clarissa C. Forneris, Serina L. Robinson, Xinjian Ji, Florian Hubrich, Clara Chepkirui, Daniel U. Richter, Stefanie Huber, Philipp Rust, Alena B. Streiff, Qi Zhang, Jeffrey W. Bode, Jörn Piel
Publikováno v:
Chem, 8 (10)
β-Amino residues are regarded as extremely rare features among ribosomal products. They can be installed by a remarkable non-canonical enzymatic splicing process occurring in some Nif11-type ribosomally synthesized and posttranslationally modified p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fddd4bd2c294c8e54a752eb14b923d0d
https://hdl.handle.net/20.500.11850/578198
https://hdl.handle.net/20.500.11850/578198
Autor:
Lucas Paoli, Hans-Joachim Ruscheweyh, Clarissa C. Forneris, Florian Hubrich, Satria Kautsar, Agneya Bhushan, Alessandro Lotti, Quentin Clayssen, Guillem Salazar, Alessio Milanese, Charlotte I. Carlström, Chrysa Papadopoulou, Daniel Gehrig, Mikhail Karasikov, Harun Mustafa, Martin Larralde, Laura M. Carroll, Pablo Sánchez, Ahmed A. Zayed, Dylan R. Cronin, Silvia G. Acinas, Peer Bork, Chris Bowler, Tom O. Delmont, Josep M. Gasol, Alvar D. Gossert, André Kahles, Matthew B. Sullivan, Patrick Wincker, Georg Zeller, Serina L. Robinson, Jörn Piel, Shinichi Sunagawa
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature, 607(7917), 111-118
Nature
Nature, 607 (7917)
Nature 607 (2022) 7917
instname
Nature, 607(7917), 111-118
Nature
Nature, 607 (7917)
Nature 607 (2022) 7917
8 pages, 4 figures, supplementary information https://doi.org/10.1038/s41586-022-04862-3.-- This Article is contribution number 130 of Tara Oceans
Natural microbial communities are phylogenetically and metabolically diverse. In addition to under
Natural microbial communities are phylogenetically and metabolically diverse. In addition to under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f2f4533523bcd8b38d773d04f8c87b
http://hdl.handle.net/10261/278488
http://hdl.handle.net/10261/278488
Autor:
Quentin Clayssen, Georg Zeller, Martin Larralde, Patrick Wincker, Chris Bowler, Peer Bork, Satria A. Kautsar, Jörn Piel, Serina L. Robinson, Clarissa C. Forneris, Alessio Milanese, Shinichi Sunagawa, Matthew B. Sullivan, Guillem Salazar, Pablo Sánchez, Silvia G. Acinas, Laura M. Carroll, Hans-Joachim Ruscheweyh, Lucas Paoli, Tom O. Delmont, Dylan R. Cronin, Ahmed A. Zayed, Daniel Gehrig
SummaryMicrobes are phylogenetically and metabolically diverse. Yet capturing this diversity, assigning functions to host organisms and exploring the biosynthetic potential in natural environments remains challenging. We reconstructed >25,000 draft g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8813d5cd53045e69c399ffdcf421e70
https://doi.org/10.1101/2021.03.24.436479
https://doi.org/10.1101/2021.03.24.436479
Publikováno v:
Angewandte Chemie. 130:8180-8184
The bioactivity of vancomycin is enabled by three aromatic crosslinks, the biosynthesis of which has been an active area of investigation for two decades. Two cytochrome P450 enzymes, OxyB and OxyA, have been shown to introduce bisaryl ether linkages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efeb08250f5f9cfd76f1ede7471c0a4
https://doi.org/10.1002/ange.201802856
https://doi.org/10.1002/ange.201802856
Autor:
Clarissa C. Forneris, Mohammad R. Seyedsayamdost, Seyma Ozturk, Andy K. L. Nguy, Erik J. Sorensen
Publikováno v:
The Journal of Organic Chemistry. 83:7309-7317
We report a general method for synthesizing diverse d-Tyr analogues, one of the constituents of the antibiotic vancomycin, using a Negishi cross-coupling protocol. Several analogues were incorporated into the vancomycin substrate-peptide and reacted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a539ea622febb00441cdbc5aeb0853ed
https://doi.org/10.1021/acs.joc.8b00916
https://doi.org/10.1021/acs.joc.8b00916
Autor:
Mohammad R. Seyedsayamdost, Marcus I. Gibson, Clarissa C. Forneris, Behnam Nazari, Kelsey R. Schramma, Kyuho Moon
Publikováno v:
MedChemComm. 8:780-788
Glycopeptide antibiotics (GPAs) have served as potent clinical drugs and as an inspiration to chemists in various disciplines. Among known GPAs, complestatin, chloropeptin, and kistamicin are unique in that they contain an unusual indole–phenol cro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a1de29611431869343cfa2b4e1d68cd
https://doi.org/10.1039/c6md00637j
https://doi.org/10.1039/c6md00637j
Publikováno v:
Tetrahedron. 74(26)
The biosynthesis of glycopeptide antibiotics (GPAs) has been an active area of research for decades. Nonetheless, insights into the activity of the cytochrome P450 enzymes required for installing the aromatic crosslinks, which form their cup-shaped t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d767460250daa1d27a62b47ec09b8a1
https://pubmed.ncbi.nlm.nih.gov/30386000
https://pubmed.ncbi.nlm.nih.gov/30386000
Publikováno v:
Organic letters. 20(19)
The first synthesis of the tetracyclic aromatic compound furo[2,3- g]thieno[2,3- e]indole ("FTI") is described. The synthetic strategy features a photochemical benzannulation based on the reaction of an α-diazo ketone and ynamide which assembles a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107680a9343e58c1bde72c0865d8996d
https://pubmed.ncbi.nlm.nih.gov/30256110
https://pubmed.ncbi.nlm.nih.gov/30256110
Publikováno v:
Biochemistry. 57(4)
Streptide is a ribosomally synthesized and post-translationally modified peptide with a unique cyclization motif consisting of an intramolecular lysine–tryptophan cross-link. Three radical S-adenosylmethionine enzymes, StrB, AgaB, and SuiB from dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46618cda3ff10b8d24e9b0d6cacc6dbc
https://pubmed.ncbi.nlm.nih.gov/29320164
https://pubmed.ncbi.nlm.nih.gov/29320164
Covalent cross-links play an important role in tailoring the structure and bioactivity of peptide natural products. While many peptide cross-links can be achieved by reactions involving heterolytic chemistries, some require radical mechanisms to acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ad6ccd4757a9fbf7b108cb51abb684b
https://doi.org/10.1039/9781788010153-00141
https://doi.org/10.1039/9781788010153-00141