23ME-00610, a genetically informed, first-in-class antibody targeting CD200R1 to enhance antitumor T cell function

Autor: Jill Fenaux, Xin Fang, Yao-ming Huang, Cristina Melero, Caroline Bonnans, Earth Light Lowe, Tiziana Palumbo, Cecilia Lay, Zuoan Yi, Aileen Zhou, Mauro Poggio, Wei-Jen Chung, Sophia R. Majeed, Dylan Glatt, Alice Chen, Maike Schmidt, Clarissa C. Lee

Publikováno v: OncoImmunology, Vol 12, Iss 1 (2023)

ABSTRACTImmune checkpoint inhibition (ICI) has revolutionized cancer treatment; however, only a subset of patients benefit long term. Therefore, methods for identification of novel checkpoint targets and development of therapeutic interventions again

Externí odkaz: https://doaj.org/article/5b1a4e2f8e6a433f9b2901ba88665afe

required to maintain repression2 Is a Novel Protein That Facilitates Locus-Specific Paramutation in Maize

Autor: Alice Barkan, Jerry L. Kermicle, Joy-El R. Barbour, Rosalind Williams-Carrier, Susan E. Parkinson, Clarissa C. Lee, Jana P. Lim, Irene T. Liao, Blake C. Meyers, Stacey A. Simon, Jay B. Hollick, Jennifer L. Stonaker

Publikováno v: The Plant Cell. 24:1761-1775

Meiotically heritable epigenetic changes in gene regulation known as paramutations are facilitated by poorly understood trans-homolog interactions. Mutations affecting paramutations in maize (Zea mays) identify components required for the accumulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2f87c62ab5bed19df18efba5212770
https://doi.org/10.1105/tpc.112.097618

The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D

Autor: David M. Sabatini, Clarissa C. Lee, Elizaveta Freinkman, Hidde L. Ploegh

Publikováno v: The Journal of biological chemistry. 289(24)

Leucine-rich repeat-containing 8 (LRRC8) proteins have been identified as putative receptors involved in lymphocyte development and adipocyte differentiation. They remain poorly characterized, and no specific function has been assigned to them. There

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc2e252fdaa5f5e574f54ccb91e615d
https://pubmed.ncbi.nlm.nih.gov/24782309

Accessory molecules for Toll-like receptors and their function

Autor: Hidde L. Ploegh, Ana M. Avalos, Clarissa C. Lee

Toll-like receptors (TLRs) are essential components of the innate immune system. Accessory proteins are required for the biosynthesis and activation of TLRs. Here, we summarize recent findings on TLR accessory proteins that are required for cell-surf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257e67b616f3ba7405981289401e3563
https://europepmc.org/articles/PMC3677579/

Changes on noncontrast magnetic resonance imaging following lymphatic surgery for upper extremity secondary lymphedema.

Autor: Babapour S; Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA., Lee C; Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA., Kim E; Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA., Kinney JR; Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA., Fanning J; Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA., Singhal D; Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA., Tsai LL; Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Electronic address: ltsai1@bidmc.harvard.edu.

Publikováno v: Journal of vascular surgery. Venous and lymphatic disorders [J Vasc Surg Venous Lymphat Disord] 2024 Aug 06, pp. 101962. Date of Electronic Publication: 2024 Aug 06.