Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Clarinda, Chua"'
Autor:
Louis Jun Ye Ong, Shumei Chia, Stephen Qi Rong Wong, Xiaoqian Zhang, Huiwen Chua, Jia Min Loo, Wei Yong Chua, Clarinda Chua, Emile Tan, Hannes Hentze, Iain Beehuat Tan, Ramanuj DasGupta, Yi-Chin Toh
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Inter-patient and intra-tumour heterogeneity (ITH) have prompted the need for a more personalised approach to cancer therapy. Although patient-derived xenograft (PDX) models can generate drug response specific to patients, they are not sustainable in
Externí odkaz:
https://doaj.org/article/85f6517cb8294c69a16c75eda4b57a62
Autor:
Guanhua Zhu, Yu A. Guo, Danliang Ho, Polly Poon, Zhong Wee Poh, Pui Mun Wong, Anna Gan, Mei Mei Chang, Dimitrios Kleftogiannis, Yi Ting Lau, Brenda Tay, Wan Jun Lim, Clarinda Chua, Tira J. Tan, Si-Lin Koo, Dawn Q. Chong, Yoon Sim Yap, Iain Tan, Sarah Ng, Anders J. Skanderup
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Circulating tumour DNA (ctDNA) represents a non-invasive option to monitor cancer progression. Here, the authors perform deep sequencing of plasma cell-free DNA, and find that nucleosome-dependent cfDNA degradation at 6 specific regulatory regions is
Externí odkaz:
https://doaj.org/article/3c974350bb8a41b0a12aa9c3b0c56857
Autor:
Min Thura, Abdul Qader Al-Aidaroos, Abhishek Gupta, Cheng Ean Chee, Soo Chin Lee, Kam Man Hui, Jie Li, Yeoh Khay Guan, Wei Peng Yong, Jimmy So, Wee Joo Chng, Chin Hin Ng, Jianbiao Zhou, Ling Zhi Wang, John Shyi Peng Yuen, Henry Sun Sien Ho, Sim Mei Yi, Edmund Chiong, Su Pin Choo, Joanne Ngeow, Matthew Chau Hsien Ng, Clarinda Chua, Eugene Shen Ann Yeo, Iain Bee Huat Tan, Joel Xuan En Sng, Nicholas Yan Zhi Tan, Jean Paul Thiery, Boon Cher Goh, Qi Zeng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into
Externí odkaz:
https://doaj.org/article/a0d6749bcea14e23bb0de1ac495322d3
Autor:
Min Thura, Abdul Qader Al-Aidaroos, Abhishek Gupta, Cheng Ean Chee, Soo Chin Lee, Kam Man Hui, Jie Li, Yeoh Khay Guan, Wei Peng Yong, Jimmy So, Wee Joo Chng, Chin Hin Ng, Jianbiao Zhou, Ling Zhi Wang, John Shyi Peng Yuen, Henry Sun Sien Ho, Sim Mei Yi, Edmund Chiong, Su Pin Choo, Joanne Ngeow, Matthew Chau Hsien Ng, Clarinda Chua, Eugene Shen Ann Yeo, Iain Bee Huat Tan, Joel Xuan En Sng, Nicholas Yan Zhi Tan, Jean Paul Thiery, Boon Cher Goh, Qi Zeng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/f8ffb83b0f494741802b21338c674764
Autor:
Syed Moiz Ahmed, Priya Dharshana Ramani, Stephen Qi Rong Wong, Xiaodan Zhao, Roland Ivanyi-Nagy, Tang Choong Leong, Clarinda Chua, Zhizhong Li, Hannes Hentze, Iain BeeHuat Tan, Jie Yan, Ramanuj DasGupta, Peter Dröge
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0215696 (2019)
The transient build-up of DNA supercoiling during the translocation of replication forks threatens genome stability and is controlled by DNA topoisomerases (TOPs). This crucial process has been exploited with TOP poisons for cancer chemotherapy. Howe
Externí odkaz:
https://doaj.org/article/369e5b0373bd4d7c90c5113ab842ebb7
Autor:
Tsai‐Sheng Yang, Hong‐Hwa Chen, Lin Bo‐Wen, Tae Won Kim, Jong Gwang Kim, Joong Bae Ahn, Myung‐Ah Lee, Johnson Lin, Gwo Fuang Ho, Le Tuan Anh, Sally Temraz, Matthew Burge, Clarinda Chua, Jason Huang, Young Suk Park
Publikováno v:
Asia-Pacific Journal of Clinical Oncology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84d9564df56f55a1e15103567e3aaaca
https://doi.org/10.1111/ajco.13920
https://doi.org/10.1111/ajco.13920
Autor:
Kah Ling Lim, Jian Hang Lam, Joo Guan Yeo, Iain Beehuat Tan, Felicia Y.T. Wee, Wei Keat Wan, Joe Yeong, Tony Kiat Hon Lim, Michelle Hong, Si-Lin Koo, Clarinda Chua, Tong Seng Lim, Wei Qiang Leow
Publikováno v:
Cancer Immunology, Immunotherapy
Regulatory T cells (Tregs) are often enriched in tumors, where their immunosuppressive function has a key role in tumor persistence and progression. In colorectal cancer (CRC), however, Tregs are frequently associated with an improved clinical outcom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02dee5c89641835e50548369dcb1507
https://doi.org/10.1007/s00262-021-02859-x
https://doi.org/10.1007/s00262-021-02859-x
Autor:
Semih Can Akıncılar, Joelle Yi Heng Chua, Qin Feng Ng, Claire Hian Tzer Chan, Zahra Eslami-S, Kaijing Chen, Joo-Leng Low, Surendar Arumugam, Luay Aswad, Clarinda Chua, Iain Beehuat Tan, Ramanuj DasGupta, Melissa Jane Fullwood, Vinay Tergaonkar
Publikováno v:
Nucleic acids research.
Transcriptional reactivation of hTERT is the limiting step in tumorigenesis. While mutations in hTERT promoter present in 19% of cancers are recognized as key drivers of hTERT reactivation, mechanisms by which wildtype hTERT (WT-hTERT) promoter is re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b58bc6f7687976a8b1c08836ea43d43
https://pubmed.ncbi.nlm.nih.gov/35697349
https://pubmed.ncbi.nlm.nih.gov/35697349
Autor:
Huipeng Li, Elise T. Courtois, Debarka Sengupta, Yuliana Tan, Kok Hao Chen, Jolene Jie Lin Goh, Say Li Kong, Clarinda Chua, Lim Kiat Hon, Wah Siew Tan, Mark Wong, Paul Jongjoon Choi, Lawrence J. K. Wee, Axel M. Hillmer, Iain Beehuat Tan, Paul Robson, Shyam Prabhakar
Publikováno v:
Nature Genetics. 55:166-166
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea8f50686371a3591e5684dac4475739
https://doi.org/10.1038/s41588-022-01281-y
https://doi.org/10.1038/s41588-022-01281-y
Autor:
Ignasius Joanito, Pratyaksha Wirapati, Nancy Zhao, Zahid Nawaz, Grace Yeo, Fiona Lee, Christine L. P. Eng, Dominique Camat Macalinao, Merve Kahraman, Harini Srinivasan, Vairavan Lakshmanan, Sara Verbandt, Petros Tsantoulis, Nicole Gunn, Prasanna Nori Venkatesh, Zhong Wee Poh, Rahul Nahar, Hsueh Ling Janice Oh, Jia Min Loo, Shumei Chia, Lih Feng Cheow, Elsie Cheruba, Michael Thomas Wong, Lindsay Kua, Clarinda Chua, Andy Nguyen, Justin Golovan, Anna Gan, Wan-Jun Lim, Yu Amanda Guo, Choon Kong Yap, Brenda Tay, Yourae Hong, Dawn Qingqing Chong, Aik-Yong Chok, Woong-Yang Park, Shuting Han, Mei Huan Chang, Isaac Seow-En, Cherylin Fu, Ronnie Mathew, Ee-Lin Toh, Lewis Z. Hong, Anders Jacobsen Skanderup, Ramanuj DasGupta, Chin-Ann Johnny Ong, Kiat Hon Lim, Emile K. W. Tan, Si-Lin Koo, Wei Qiang Leow, Sabine Tejpar, Shyam Prabhakar, Iain Beehuat Tan
Publikováno v:
Nature genetics. 54(7)
The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed 373,058 single-cell transcriptomes from 63 patients, focusing on 49,155
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb4df11888eb6ef0ad590958d97b70b
https://pubmed.ncbi.nlm.nih.gov/35918514
https://pubmed.ncbi.nlm.nih.gov/35918514