Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice.

Autor: Hossain AS; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Japan; Department of Pharmacy, Varendra University, Bangladesh., Clarin MTRDC; School of Integrative and Global Major, University of Tsukuba, Japan; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Japan; National Institute for Material Science, Japan., Kimura K; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Japan., Biggin G; Wellcome Trust Centre for Cell-Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, UK., Taga Y; Nippi Research Institute of Biomatrix, Japan., Uto K; National Institute for Material Science, Japan., Yamagishi A; National Institute of Advanced Industrial Science and Technology, Japan., Motoyama E; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Japan., Narenmandula; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Japan., Mizuno K; Nippi Research Institute of Biomatrix, Japan., Nakamura C; National Institute of Advanced Industrial Science and Technology, Japan., Asano K; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Japan., Ohtsuki S; Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Japan., Nakamura T; Department of Pharmacology, Kansai Medical University, Japan., Kanki S; Department of Surgery, Osaka Medical and Pharmaceutical University, Japan., Baldock C; Wellcome Trust Centre for Cell-Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, UK., Raja E; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Japan. Electronic address: rajaerna@tara.tsukuba.ac.jp., Yanagisawa H; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Japan. Electronic address: hkyanagisawa@tara.tsukuba.ac.jp.

Publikováno v: Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2024 Nov 28. Date of Electronic Publication: 2024 Nov 28.