Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Clarence T. T. Wong"'
Autor:
Kelvin C. C. Pong, Yuen Sze Lai, Roy Chi Hang Wong, Alan Chun Kit Lee, Sam C. T. Chow, Jonathan C. W. Lam, Ho Pui Ho, Clarence T. T. Wong
Publikováno v:
Biosensors, Vol 14, Iss 8, p 392 (2024)
Three-dimensional (3D) spheroid models are crucial for cancer research, offering more accurate insights into tumour biology and drug responses than traditional 2D cell cultures. However, inconsistent and low-throughput spheroid production has hindere
Externí odkaz:
https://doaj.org/article/902979ed7fed4597805d5097657042e2
Autor:
Bo Tang, Kwai Man Lau, Yunxin Zhu, Chihao Shao, Wai-Ting Wong, Larry M. C. Chow, Clarence T. T. Wong
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 71 (2024)
Delivering bioactive proteins into cells without carriers presents significant challenges in biomedical applications due to limited cell membrane permeability and the need for targeted delivery. Here, we introduce a novel carrier-free method that add
Externí odkaz:
https://doaj.org/article/0caeb3b8fb77445485d4ff5e60824df5
Publikováno v:
Frontiers in Chemistry, Vol 2 (2014)
Serine/Threonine ligation (STL) has emerged as an alternative tool for protein chemical synthesis, bioconjugations as well as macrocyclization of peptides of various sizes. Owning to the high abundance of Ser/Thr residues in natural peptides and prot
Externí odkaz:
https://doaj.org/article/052daae70de14a9cb9cdc99e95c49fbb
Publikováno v:
Chemical Communications. 59:3471-3474
A smart photosensitiser has been designed and synthesised that can be selectively activated by the senescence-associated β-galactosidase in senescent cells, leading to effective killing of the cells via photodynamic action.
Publikováno v:
Journal of the American Chemical Society. 144:10647-10658
Delivery of functional proteins into the intracellular space has been a challenging task that could lead to a myriad of therapeutic applications. We report herein a novel bioconjugation strategy for enzyme modification and selective delivery into can
Publikováno v:
Colorants; Volume 1; Issue 2; Pages: 193-207
Photodynamic therapy (PDT) is an established treatment modality for a range of superficial and localized cancers. There has been tremendous interest in the development of advanced photosensitizers that exhibit superior photophysical properties, high
Publikováno v:
Chemical Communications. 56:11941-11944
A novel synthetic strategy for in situ cyclisation of peptides and conjugation with functional boron dipyrromethenes (BODIPYs) has been developed. Linear peptides with up to 16 amino acid residues can be cyclised effectively and the resulting conjuga
Publikováno v:
European Journal of Medicinal Chemistry. 174:56-65
A zinc(II) phthalocyanine substituted with three 2,4-dinitrobenzenesulfonate (DNBS) groups and a cyclic arginine-glycine-aspartic acid (cRGDfK) moiety was prepared and characterized. With three strongly electron-withdrawing DNBS groups, this compound
Autor:
Irene L. Ang, Simon Ming-Yuen Lee, Qiwen Liao, Terence C.W. Poon, Gandhi Rádis-Baptista, Guiyi Gong, Shirley W. I. Siu, Kate M. K. Lei, Clarence T. T. Wong
Publikováno v:
Archives of Toxicology. 93:1745-1767
Venoms from marine animals have been recognized as a new emerging source of peptide-based therapeutics. Several peptide toxins from sea anemone have been investigated as therapeutic leads or pharmacological tools. Venom complexity should be further h
Publikováno v:
Journal of medicinal chemistry. 64(4)
A facile procedure for in situ peptide cyclization and phthalocyanine conjugation was developed by utilizing a bifunctional linker incorporated with a bis(bromomethyl)benzene unit and a cyclopentadiene moiety. These functional groups facilitated the