Zobrazeno 1 - 10
of 321
pro vyhledávání: '"Clarence T. Sasaki"'
Publikováno v:
Cancer Medicine, Vol 8, Iss 9, Pp 4417-4427 (2019)
Abstract Biliary reflux has been considered a potential risk factor in upper aerodigestive tract malignancies. It is not yet clearly known how pH affects the bile‐induced activation of NF‐κB and its related oncogenic pathway previously linked to
Externí odkaz:
https://doaj.org/article/92a8fcfdf8d64a338fe4f7f6bf36a978
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 4, Pp 374-386 (2018)
PURPOSE: Bile-containing gastroesophageal reflux may promote cancer at extraesophageal sites. Acidic bile can accelerate NF-κB activation and molecular events, linked to premalignant changes in murine hypopharyngeal mucosa (HM). We hypothesize that
Externí odkaz:
https://doaj.org/article/1c03e2b5f55d467ca61c12614772837f
Autor:
Clarence T. Sasaki, Dimitra P. Vageli
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 6, Pp 329-338 (2016)
Gastroduodenal refluxate found in the upper aerodigestive tract is not clinically uncommon. We recently demonstrated the neoplastic potential of gastroduodenal fluids (GDF) on hypopharyngeal mucosa, via NF-κB, using in vitro and in vivo models. Here
Externí odkaz:
https://doaj.org/article/8d53c487d41d4ec8954d5749caf2b279
Autor:
Sotirios G. Doukas, Dimitra P. Vageli, George Lazopoulos, Demetrios A. Spandidos, Clarence T. Sasaki, Aristidis Tsatsakis
Publikováno v:
Cells, Vol 9, Iss 4, p 1031 (2020)
Tobacco smoking is a common risk factor for lung cancer and head and neck cancer. Molecular changes such as deregulation of miRNA expression have been linked to tobacco smoking in both types of cancer. Dysfunction of the Mismatch DNA repair (MMR) mec
Externí odkaz:
https://doaj.org/article/4c0d48666f38467590705e97d8b3e1ef
Autor:
Clarence T. Sasaki
This book explains three principal functional priorities of the larynx: protection, respiration, and phonation. Working on the basis that a sound understanding of these functional priorities is essential to the management of the myriad diseases beset
Autor:
Heather A Edwards, Clarence T. Sasaki, Saral Mehra, Benjamin L. Judson, Rahmatullah Rahmati, Said Izreig, Michael Hajek
Publikováno v:
Laryngoscope Investigative Otolaryngology
Objective Head and neck squamous cell carcinoma (HNSCC) describes a set of malignancies of the head and neck that continue to inflict considerable morbidity and mortality. Because HNSCC often presents at an advanced stage, patients frequently undergo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21479bc3aecb24ac5d6fea74d49e71cb
http://europepmc.org/articles/PMC7752058
http://europepmc.org/articles/PMC7752058
Autor:
Panagiotis G Doukas, David A. Kasle, Dimitra P. Vageli, Sotirios G. Doukas, Clarence T. Sasaki
Publikováno v:
Oncotarget
Supraesophageal bile reflux at strongly acidic pH can cause hypopharyngeal squamous cell cancer, through activation of the oncogenic NF-κB-related pathway. We hypothesize that topical pre- or post-application of pharmacologic NF-κB inhibitor, BAY 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6bde99c542e83885cb2a1621ec70213
http://europepmc.org/articles/PMC7476734
http://europepmc.org/articles/PMC7476734
Publikováno v:
Journal of Cellular and Molecular Medicine
Bile at strongly acidic pH exerts a carcinogenic effect on the hypopharynx, based upon recent pre‐clinical studies that support its role as an independent risk factor. We recently demonstrated in vitro that curcumin can prevent oncogenic profile of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2272f4921118988b325039ae17410a59
https://doi.org/10.1111/jcmm.15640
https://doi.org/10.1111/jcmm.15640
Publikováno v:
Cancer Medicine, Vol 8, Iss 9, Pp 4417-4427 (2019)
Cancer Medicine
Cancer Medicine
Biliary reflux has been considered a potential risk factor in upper aerodigestive tract malignancies. It is not yet clearly known how pH affects the bile‐induced activation of NF‐κB and its related oncogenic pathway previously linked to hypophar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52ce94f58f438bbf5e71c71daea6283
https://doaj.org/article/92a8fcfdf8d64a338fe4f7f6bf36a978
https://doaj.org/article/92a8fcfdf8d64a338fe4f7f6bf36a978
Autor:
Sotirios G. Doukas, Linda Bartoshuk, R. Peter Manes, Elias Michaelides, Joseph Santos-Sacchi, Todd Spock, Jordan M. Sukys, Clarence T. Sasaki
Publikováno v:
Handbook of Laboratory Animal Science ISBN: 9780429439964
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5684761a32789c0628e8914dbbe4d525
https://doi.org/10.1201/9780429439964-34
https://doi.org/10.1201/9780429439964-34