Výsledky vyhledávání - "Clarence S. Rooney"

Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one and analogs

Autor: Jacob M. Hoffman, Barnes Jl, Clarence S. Rooney, Anthony M. Smith, Thorsten E. Fisher, James H. Jones, Dona L. Bamberger, Thomas Cm, Theresa M. Williams, John S. Wai

Publikováno v: Journal of Medicinal Chemistry. 36:953-966

A new series of potent specific 2-pyridinone reverse transcriptase (RT) inhibitors was developed based on the preliminary development lead 3-[(phthalmido)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one (3), a non-nucleoside derivative which exhibited weak a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5c0b5f792f834681aed512f1491311
https://doi.org/10.1021/jm00060a002

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5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase

Autor: William J. Greenlee, S K Balani, L. R. Kauffman, Mark E. Goldman, Clarence S. Rooney, Jon H. Condra, Emilio A. Emini, S. C. Mactough, Terrence M. Ciccarone, Theresa M. Williams

Publikováno v: Journal of medicinal chemistry. 36(9)

A series of highly potent, structurally novel, non-nucleoside RT inhibitors has been described. Low nanomolar concentrations of 5-chloro-3-(phenylsulfonyl)-indole-2-carboxamide (1) inhibit the HIV-1 RT enzyme in vitro and HTLVIIIb viral spread in MT-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc6ccdc5cee375b7a1784cc0e52b4e3
https://pubmed.ncbi.nlm.nih.gov/7683725

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Synthesis and evaluation of 2-pyridinone derivatives as specific HIV-1 reverse transcriptase inhibitors. 3. Pyridyl and phenyl analogs of 3-aminopyridin-2(1H)-one

Autor: Jacob M. Hoffman, S. C. Mactough, Dona L. Bamberger, Thorsten E. Fisher, W. S. Saari, John S. Wai, Clarence S. Rooney, R. J. Hudcosky, Theresa M. Williams, Thomas Cm

Publikováno v: Journal of medicinal chemistry. 36(2)

In an ongoing effort to develop novel nonnucleoside, specific human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) inhibitors, a series of 3-[(pyridylmethyl)amino]- and 3-[(phenylmethyl)amino]-2-pyridinone derivatives was synthesize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310255646dee6bd531f361bd8b87cfcb
https://pubmed.ncbi.nlm.nih.gov/7678654

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1,8-Naphthyridines. Part III. Synthesis of some 6-substituted-1,8-naphthyridin-2(1H)ones

Autor: Haydn W. R. Williams, Clarence S. Rooney, Eva Eichler

Publikováno v: Journal of Heterocyclic Chemistry. 13:841-844

The syntheses of some 1,8-naphthyridines substituted in the 6-position with heterocyclic groups are described. A synthetic route to 6-amino-5,7-dimethyl-1,8-naphthyridin-2(1H)one is also presented.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c0cc4ac7cf359cb8e508dce298e86ab
https://doi.org/10.1002/jhet.5570130429

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Cyclic amidine inhibitors of indolamine N-methyltransferase

Autor: Edward J. Cragoe, L. R. Mandel, Clarence S. Rooney, Paul Anderson, Norman R. Hunter, Joshua Rokach, G. Reader, Pierre Hamel

Publikováno v: Journal of Medicinal Chemistry. 22:237-247

Syntheses of a large number of mono- and bicyclic, as well as a few tricyclic, amidine derivatives related to 2,3,4,6,7,8,-hexahydropyrrolo[1,2-a]pyrimidine (DBN) are reported. In vitro potencies for inhibition of the enzyme indolamine N-methyltransf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2bd3f82b3964213e8b7b01e521ef2c
https://doi.org/10.1021/jm00189a004

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Inhibitors of glycolic acid oxidase. 4-Substituted-2,4-dioxobutanoic acid derivatives

Autor: Cragoe Edward J, W. C. Randall, K. B. Streeter, Eva Eichler, Arthur A. Patchett, Harvey Schwam, Haydn W. R. Williams, Stuart R. Michelson, Clarence S. Rooney, D. Taub

Publikováno v: Journal of Medicinal Chemistry. 26:1196-1200

Fourteen new 4-substituted 2,4-dioxobutanoic acids have been synthesized. These compounds, all of which contain lipophilic 4-substituents, are potent inhibitors in vitro of porcine liver glycolic acid oxidase. The I50 value of the two most potent rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc888470b083d5ad6e186c91509a78b
https://doi.org/10.1021/jm00362a020

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