Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Clarence R. Manuel"'
Autor:
Tomas Vaisar, John E. Hokanson, Daniel Mar, Jenny E. Kanter, Karol Bomsztyk, Shelley Barnhart, Karin E. Bornfeldt, Jay W. Heinecke, Mark J. Graham, Gregory L. Kinney, Masami Shimizu-Albergine, Janet K. Snell-Bergeon, Rebecca A. Haeusler, Baohai Shao, Farah Kramer, Rosanne M. Crooke, Clarence R. Manuel
Publikováno v:
Journal of Clinical Investigation. 129:4165-4179
Type 1 diabetes mellitus (T1DM) increases the risk of atherosclerotic cardiovascular disease (CVD) in humans by poorly understood mechanisms. Using mouse models of T1DM-accelerated atherosclerosis, we found that relative insulin deficiency rather tha
Publikováno v:
J Clin Invest
De novo lipogenesis is tightly regulated by insulin and nutritional signals to maintain metabolic homeostasis. Excessive lipogenesis induces lipotoxicity, leading to nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. Genetic lipogenic prog
Autor:
Clarence R. Manuel, Maureen J. Charron, Sandra E. Reznik, Lyda Williams, Swapna Munnangi, Emmanuel S. Burgos, Ryan Pekson, Patricia M. Vuguin
Publikováno v:
Am J Pathol
The mechanism by which poor maternal nutrition can affect the long-term health of offspring is poorly understood. In mice, we previously found that maternal high-fat diet (HFD) exposure results in reduced fetal growth regardless of maternal genotype.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cbb431a855a36f67c278202b93ea8d
https://europepmc.org/articles/PMC6892186/
https://europepmc.org/articles/PMC6892186/
Publikováno v:
Current pharmaceutical design. 23(40)
Background Preterm birth (PTB) is a multifactorial syndrome occurring before the 37th week of fullterm pregnancy [1]. Babies delivered preterm experience short-term and long-term complications affecting multiple organ systems, and serious maternal co
Publikováno v:
American Journal of Obstetrics and Gynecology. 220:596.e1-596.e28
Background Preterm delivery accounts for 85% of perinatal morbidity and mortality. Although the consumption of a high-fat diet leads to exaggerated proinflammatory responses and, in pregnant women, increased rates of spontaneous preterm birth, the un
Publikováno v:
American Journal of Reproductive Immunology. 80:e13057
Publikováno v:
American Journal of Reproductive Immunology. 80:e12868
Problem Complications from prematurity are the leading cause of death among children under 5 years of age. Although clinical studies have shown a positive correlation between maternal high-fat diet (HFD) and preterm birth (PTB), the underlying mechan