Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Clarence A, Broomfield"'
Publikováno v:
Military Medicine
The Multi-Threat Medical Countermeasure (MTMC) hypothesis has been proposed with the aim of developing a single countermeasure drug with efficacy against different pathologies caused by multiple classes of chemical warfare agents. Although sites and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87c725353c019d178dca4627abb91bc
https://doi.org/10.7205/milmed.169.11.850
https://doi.org/10.7205/milmed.169.11.850
Autor:
Michelle Ross, Brennie E. Hackley, Richard E. Sweeney, Damon L. Burman, Clarence A. Broomfield, Carmen M. Arroyo
Publikováno v:
Environmental Toxicology and Pharmacology. 17:87-94
The proinflammatory cytokine human interleukin-6 (hIL-6) plays an important role in the early and late courses of inflammation, trauma, and wound healing caused by sulfur mustard (HD). Previously, we demonstrated that hIL-6 might be involved in the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a35bf95af9f91039e0ded65d455fa1
https://doi.org/10.1016/j.etap.2004.03.004
https://doi.org/10.1016/j.etap.2004.03.004
Autor:
Charlene M. Corun, Robert K. Kan, Carmen M. Arroyo, Marian R. Nelson, Juanita J. Guzman, David W. Kahler, Clarence A. Broomfield, Damon L. Burman
Publikováno v:
Pharmacology & Toxicology. 92:204-213
The regulatory effects of the active form of vitamin D, 1-alpha, 25-dihydroxyvitamin D3 (1-alpha, 25 (OH)2D3) were assessed on the cytokine and chemokine secretion induced by sulfur mustard on human skin fibroblasts and human epidermal keratinocytes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::169587be06f97d10bec20fa245017118
https://doi.org/10.1034/j.1600-0773.2003.920503.x
https://doi.org/10.1034/j.1600-0773.2003.920503.x
Publikováno v:
Journal of Applied Toxicology. 23:177-186
Despite the contrasts in chemistry and toxicity, for blister and nerve chemical warfare agents there may be some analogous proteolytic and inflammatory mediators and pathological pathways that can be pharmacological targets for a single-drug multi-th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81072180db9a0a662f2f2aaf9bab553c
https://doi.org/10.1002/jat.901
https://doi.org/10.1002/jat.901
Publikováno v:
Cell Biology and Toxicology. 18:175-180
The toxicity of the chemical warfare blistering agent sulfur mustard (2,2'-dichlorodiethyl sulfide; SM) has been investigated for nearly a century; however, the toxicological mechanisms of SM remain obscure and no antidote exists. The similarity of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac891cc26b296d4a70cfc79749312977
https://doi.org/10.1023/a:1015511720481
https://doi.org/10.1023/a:1015511720481
Publikováno v:
Journal of Applied Toxicology. 21:S43-S46
In the 50 years since nerve agents were developed a great deal has been learned about their acute toxicity, treatment and prophylactic strategies. However, the currently fielded treatments are not significantly different from those available at the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67879a5cd5f48ce0880808cc51ff937d
https://doi.org/10.1002/jat.804
https://doi.org/10.1002/jat.804
Publikováno v:
Journal of Applied Toxicology. 20:S77-S80
Sulfur mustard (HD)-increased proteolytic activity, HD-enhanced expression of Fc receptor (FcR) on human epidermal keratinocytes (HEK) and associated inflammatory responses may contribute to HD pathology. Like the FcR, the first component of the clas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a32849ff62e018a546b79e4df3a4ea3
https://doi.org/10.1002/1099-1263(200012)20:1+<::aid-jat686>3.0.co
https://doi.org/10.1002/1099-1263(200012)20:1+<::aid-jat686>3.0.co
Autor:
Ellen M. Kurt, Carmen M. Arroyo, Robert J. Schafer, Clarence A. Broomfield, Alasdair J. Carmichael
Publikováno v:
Journal of Applied Toxicology. 20:S63-S72
Cytokines play a major role in both acute and chronic inflammatory processes, including those produced by sulfur mustard (2,2'-dichlorodiethyl sulfide, HD). This study describes responses of normal human epidermal keratinocytes (NHEK) to HD, defined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::377bbd49c429cf40918b7b3bdc8cc3b0
https://doi.org/10.1002/1099-1263(200012)20:1+<::aid-jat687>3.0.co
https://doi.org/10.1002/1099-1263(200012)20:1+<::aid-jat687>3.0.co
Publikováno v:
Journal of Applied Toxicology. 21:293-296
Soman-poisoned rats display cholinergic crisis, a systemic mast cell degranulation characteristic of anaphylactic reactions and an excitotoxin-like sequential seizure and neuronal degeneration. The protection of guinea pigs from soman lethality by pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483d18c0d2f4d2071ab927721cf2c387
https://doi.org/10.1002/jat.757
https://doi.org/10.1002/jat.757
Publikováno v:
Chemico-Biological Interactions. :413-418
Because of deficiencies in the present treatments for organophosphorus anticholinesterase poisoning, we are attempting to develop a catalytic scavenger that can be administered as prophylactic protection. Currently known enzymes are inadequate for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75dbde2027402ac60c64f1e19e70b8e3
https://doi.org/10.1016/s0009-2797(99)00053-8
https://doi.org/10.1016/s0009-2797(99)00053-8