Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Clarence, Hale"'
Autor:
Shu-Chen Lu, Michelle Chen, Larissa Atangan, Elizabeth A. Killion, Renee Komorowski, Yuan Cheng, Chawita Netirojjanakul, James R. Falsey, Marina Stolina, Denise Dwyer, Clarence Hale, Shanaka Stanislaus, Todd Hager, Veena A. Thomas, John M. Harrold, David J. Lloyd, Murielle M. Véniant
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100263- (2021)
Summary: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) regulate glucose and energy homeostasis. Targeting both pathways with GIP receptor (GIPR) antagonist antibody (GIPR-Ab) and GLP-1 receptor (GLP-1R) agonis
Externí odkaz:
https://doaj.org/article/6fa1243f07684a9b91237d0446fb0986
Autor:
Clarence Hale, Murielle M. Véniant
Publikováno v:
Molecular Metabolism, Vol 46, Iss , Pp 101117- (2021)
Background: Obesity is rapidly becoming one of the world's most critical health care concerns. Comorbidities accompanying excess weight include cardiovascular disease, diabetes, and certain cancers. These comorbidities result in greater hospitalizati
Externí odkaz:
https://doaj.org/article/b120044843414d4a81f51e8b7cfbcb6f
Autor:
Marina Stolina, Xin Luo, Denise Dwyer, Chun-Ya Han, Rhonda Chen, Ying Zhang, YuMei Xiong, Yinhong Chen, Jun Yin, Artem Shkumatov, Brandon Ason, Clarence Hale, Murielle M Véniant
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0231234 (2020)
Cardiometabolic syndrome has become a global health issue. Heart failure is a common comorbidity of cardiometabolic syndrome. Successful drug development to prevent cardiometabolic syndrome and associated comorbidities requires preclinical models pre
Externí odkaz:
https://doaj.org/article/2a28d72dc487472ba9726d8fb014b07f
Autor:
Clarence Hale, Murielle M. Véniant
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 46, Iss, Pp 101117-(2021)
Molecular Metabolism, Vol 46, Iss, Pp 101117-(2021)
Background Obesity is rapidly becoming one of the world's most critical health care concerns. Comorbidities accompanying excess weight include cardiovascular disease, diabetes, and certain cancers. These comorbidities result in greater hospitalizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c158f4f528985dd339074daca90bcc42
http://europepmc.org/articles/PMC8085570
http://europepmc.org/articles/PMC8085570
Autor:
Elizabeth A. Killion, Yuan Cheng, John M. Harrold, Veena A. Thomas, Shu-Chen Lu, James R. Falsey, Chawita Netirojjanakul, David Lloyd, Clarence Hale, Todd Hager, Shanaka Stanislaus, Marina Stolina, Renee Komorowski, Larissa Atangan, Murielle M. Véniant, Denise Dwyer, Michelle Chen
Publikováno v:
Cell Reports Medicine
Cell Reports Medicine, Vol 2, Iss 5, Pp 100263-(2021)
Cell Reports Medicine, Vol 2, Iss 5, Pp 100263-(2021)
Summary Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) regulate glucose and energy homeostasis. Targeting both pathways with GIP receptor (GIPR) antagonist antibody (GIPR-Ab) and GLP-1 receptor (GLP-1R) agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ac5166f5323cefa07e391f43ee52d4
https://pubmed.ncbi.nlm.nih.gov/34095885
https://pubmed.ncbi.nlm.nih.gov/34095885
Autor:
Denise Dwyer, Ying Zhang, Xin Luo, Jun Yin, Brandon Ason, Yumei Xiong, Murielle M. Véniant, Marina Stolina, Chun-Ya Han, Clarence Hale, Yinhong Chen, Rhonda Chen
Cardiometabolic syndrome has become a global health issue. Heart failure is a common comorbidity of cardiometabolic syndrome. Successful drug development to prevent cardiometabolic syndrome and associated comorbidities requires preclinical models pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d761dd6b13f74124f02d86420dc6b7
Autor:
Murielle M Véniant, Clarence Hale, Joan Helmering, Michelle M Chen, Shanaka Stanislaus, Jim Busby, Steven Vonderfecht, Jing Xu, David J Lloyd
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40164 (2012)
Fibroblast growth factor 21 (FGF21) is a potent metabolic regulator, and pharmacological administration elicits glucose and lipid lowering responses in mammals. To delineate if adipose tissue is the predominant organ responsible for anti-diabetic eff
Externí odkaz:
https://doaj.org/article/da87ceebbe5b427fb5ea0d3269c57f7b
A volumetric method for quantifying atherosclerosis in mice by using microCT: comparison to en face.
Autor:
David J Lloyd, Joan Helmering, Stephen A Kaufman, James Turk, Matt Silva, Sergio Vasquez, David Weinstein, Brad Johnston, Clarence Hale, Murielle M Véniant
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18800 (2011)
Precise quantification of atherosclerotic plaque in preclinical models of atherosclerosis requires the volumetric assessment of the lesion(s) while maintaining in situ architecture. Here we use micro-computed tomography (microCT) to detect ex vivo ao
Externí odkaz:
https://doaj.org/article/ae7f2e2eb1cd43f9a5a2073955438af5
Publikováno v:
Endocrine Abstracts.
Fibroblast growth factor 21 (FGF21) is a potent regulator of glucose and lipid homeostasis in vivo; its most closely related subfamily member, FGF19, is known to be a critical negative regulator of bile acid synthesis. To delineate whether FGF21 also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb94fc9762ed3832298c535123902edd
https://doi.org/10.1530/endoabs.65.ja1
https://doi.org/10.1530/endoabs.65.ja1
Autor:
Xin Luo, Yumei Xiong, Clarence Hale, Yinhong Chen, Brandon Ason, Murielle M. Véniant, Jun Yin, Ying Zhang, Artem Shkumatov, Denise Dwyer, Marina Stolina, Chun-Ya Han, Rhonda Chen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0231234 (2020)
PLoS ONE, Vol 15, Iss 8, p e0231234 (2020)
Cardiometabolic syndrome has become a global health issue. Heart failure is a common comorbidity of cardiometabolic syndrome. Successful drug development to prevent cardiometabolic syndrome and associated comorbidities requires preclinical models pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf378db850501a8de88a46e1c4ccc43
https://doi.org/10.1371/journal.pone.0231234
https://doi.org/10.1371/journal.pone.0231234