Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Clare S. W. Yan"'
Autor:
Tsz Cheung, Chong, Iris L K, Wong, Jiahua, Cui, Man Chun, Law, Xuezhen, Zhu, Xuesen, Hu, Jason W Y, Kan, Clare S W, Yan, Tak Hang, Chan, Larry M C, Chow
Publikováno v:
International journal of molecular sciences. 23(21)
Overexpression of breast cancer resistance transporter (BCRP/ABCG2) in cancers has been explained for the failure of chemotherapy in clinic. Inhibition of the transport activity of BCRP during chemotherapy should reverse multidrug resistance. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37c1ff8947a2264dd2d4dfa61a2d7324
https://pubmed.ncbi.nlm.nih.gov/36362047
https://pubmed.ncbi.nlm.nih.gov/36362047
Autor:
Jason W. Y. Kan, Clare S. W. Yan, Iris L. K. Wong, Xiaochun Su, Zhen Liu, Tak Hang Chan, Larry M. C. Chow
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 15299
Biotransformation of flavonoid dimer FD18 resulted in an active metabolite FM04. It was more druggable because of its improved physicochemical properties. FM04 (EC50 = 83 nM) was 1.8-fold more potent than FD18 in reversing P-glycoprotein (P-gp)-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297ab9288971f1e08816d2d7236731c5
https://doi.org/10.3390/ijms232315299
https://doi.org/10.3390/ijms232315299
Autor:
Yunzhe Zhao, Man Chun Law, Tsz Cheung Chong, Kin-Fai Chan, Larry M.C. Chow, Shun Wan Chan, Tak Hang Chan, Jason W. Y. Kan, Clare S. W. Yan, Iris L. K. Wong
Publikováno v:
Molecular Pharmaceutics. 12:3507-3517
Flavonoid dimer FD18 is a new class of dimeric P-gp modulator that can reverse cancer drug resistance. FD18 is a potent (EC50 = 148 nM for paclitaxel), safe (selective index = 574), and selective P-glycoprotein (P-gp) modulator. FD18 can modulate mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc900f3d335ceefd336976a0e34f4f8
https://doi.org/10.1021/mp500770e
https://doi.org/10.1021/mp500770e
Autor:
Kin-Fai Chan, Jason W. Y. Kan, Iris L. K. Wong, Tak Hang Chan, Larry M.C. Chow, Clare S. W. Yan
Publikováno v:
Journal of medicinal chemistry. 55(5)
Here we report a great improvement in reversal potency of cancer drug resistance when flavonoid dimers possess a functionally substituted aminopolyethylene glycol linker. The most potent compound, 18, contains a N-benzyl group at the linker. It has m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d6ee59b8af3776985ae77380c3e0cb
https://pubmed.ncbi.nlm.nih.gov/22320402
https://pubmed.ncbi.nlm.nih.gov/22320402
Autor:
Tao Jiang, Xiaoyu Zhang, Clare S. W. Yan, Pu Yong Zhang, Iris L. K. Wong, Larry M.C. Chow, Sheng Biao Wan
Publikováno v:
Journal of medicinal chemistry. 53(14)
A series of novel N-arylalkyl-3,4-diaryl-substituted pyrrole-2,5-diones were synthesized. They exhibited promising P-gp modulating activity in a P-gp overexpressing breast cancer cell line (LCC6MDR). Compound 6 (with three methoxy groups at D-ring) d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7da2d37293b21fc03b0370d0a83343
https://pubmed.ncbi.nlm.nih.gov/20560605
https://pubmed.ncbi.nlm.nih.gov/20560605
Autor:
Yunzhe Zhao, Kin-Fai Chan, Iris L. K. Wong, Clare S. W. Yan, Toby W. S. Chow, Larry M.C. Chow, Tak Hang Chan, Dik-Lung Ma, Brendan A. Burkett
Publikováno v:
ChemMedChem. 4(4)
We recently described the modulatory activities of apigenin homodimers linked by ethylene glycol units in multidrug- resistant breast cancer and leukemic cells overexpressing ABCB1 (P-glycoprotein, P-gp). To further improve the potency of these dimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a99428e381ce60fbf11b5f4fe912b95
https://pubmed.ncbi.nlm.nih.gov/19288491
https://pubmed.ncbi.nlm.nih.gov/19288491
Autor:
Pu Yong Zhang, Iris L. K. Wong, Clare S. W. Yan, Xiao Yu Zhang, Tao Jiang, Larry M. C. Chow, Sheng Biao Wan
Publikováno v:
Journal of Medicinal Chemistry; Jul2010, Vol. 53 Issue 14, p5108-5120, 13p