Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Clare S. W. Yan"'
Autor:
Jason W. Y. Kan, Clare S. W. Yan, Iris L. K. Wong, Xiaochun Su, Zhen Liu, Tak Hang Chan, Larry M. C. Chow
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15299 (2022)
Biotransformation of flavonoid dimer FD18 resulted in an active metabolite FM04. It was more druggable because of its improved physicochemical properties. FM04 (EC50 = 83 nM) was 1.8-fold more potent than FD18 in reversing P-glycoprotein (P-gp)-media
Externí odkaz:
https://doaj.org/article/ddd118db7cb740df9d822fbe8a8fcd1d
Autor:
Tsz Cheung Chong, Iris L. K. Wong, Jiahua Cui, Man Chun Law, Xuezhen Zhu, Xuesen Hu, Jason W. Y. Kan, Clare S. W. Yan, Tak Hang Chan, Larry M. C. Chow
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13261 (2022)
Overexpression of breast cancer resistance transporter (BCRP/ABCG2) in cancers has been explained for the failure of chemotherapy in clinic. Inhibition of the transport activity of BCRP during chemotherapy should reverse multidrug resistance. In this
Externí odkaz:
https://doaj.org/article/b470e512a9744189a7e3f58b7d2ec6a0
Autor:
Yunzhe Zhao, Man Chun Law, Tsz Cheung Chong, Kin-Fai Chan, Larry M.C. Chow, Shun Wan Chan, Tak Hang Chan, Jason W. Y. Kan, Clare S. W. Yan, Iris L. K. Wong
Publikováno v:
Molecular Pharmaceutics. 12:3507-3517
Flavonoid dimer FD18 is a new class of dimeric P-gp modulator that can reverse cancer drug resistance. FD18 is a potent (EC50 = 148 nM for paclitaxel), safe (selective index = 574), and selective P-glycoprotein (P-gp) modulator. FD18 can modulate mul
Autor:
Kin-Fai Chan, Jason W. Y. Kan, Iris L. K. Wong, Tak Hang Chan, Larry M.C. Chow, Clare S. W. Yan
Publikováno v:
Journal of medicinal chemistry. 55(5)
Here we report a great improvement in reversal potency of cancer drug resistance when flavonoid dimers possess a functionally substituted aminopolyethylene glycol linker. The most potent compound, 18, contains a N-benzyl group at the linker. It has m
Autor:
Tao Jiang, Xiaoyu Zhang, Clare S. W. Yan, Pu Yong Zhang, Iris L. K. Wong, Larry M.C. Chow, Sheng Biao Wan
Publikováno v:
Journal of medicinal chemistry. 53(14)
A series of novel N-arylalkyl-3,4-diaryl-substituted pyrrole-2,5-diones were synthesized. They exhibited promising P-gp modulating activity in a P-gp overexpressing breast cancer cell line (LCC6MDR). Compound 6 (with three methoxy groups at D-ring) d
Autor:
Yunzhe Zhao, Kin-Fai Chan, Iris L. K. Wong, Clare S. W. Yan, Toby W. S. Chow, Larry M.C. Chow, Tak Hang Chan, Dik-Lung Ma, Brendan A. Burkett
Publikováno v:
ChemMedChem. 4(4)
We recently described the modulatory activities of apigenin homodimers linked by ethylene glycol units in multidrug- resistant breast cancer and leukemic cells overexpressing ABCB1 (P-glycoprotein, P-gp). To further improve the potency of these dimer
Autor:
Pu Yong Zhang, Iris L. K. Wong, Clare S. W. Yan, Xiao Yu Zhang, Tao Jiang, Larry M. C. Chow, Sheng Biao Wan
Publikováno v:
Journal of Medicinal Chemistry; Jul2010, Vol. 53 Issue 14, p5108-5120, 13p