Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Clare S. W. Yan"'
1
Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)
Autor: Tsz Cheung, Chong, Iris L K, Wong, Jiahua, Cui, Man Chun, Law, Xuezhen, Zhu, Xuesen, Hu, Jason W Y, Kan, Clare S W, Yan, Tak Hang, Chan, Larry M C, Chow
Publikováno v: International journal of molecular sciences. 23(21)
Overexpression of breast cancer resistance transporter (BCRP/ABCG2) in cancers has been explained for the failure of chemotherapy in clinic. Inhibition of the transport activity of BCRP during chemotherapy should reverse multidrug resistance. In this
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37c1ff8947a2264dd2d4dfa61a2d7324
https://pubmed.ncbi.nlm.nih.gov/36362047
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2
Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel
Autor: Jason W. Y. Kan, Clare S. W. Yan, Iris L. K. Wong, Xiaochun Su, Zhen Liu, Tak Hang Chan, Larry M. C. Chow
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 15299
Biotransformation of flavonoid dimer FD18 resulted in an active metabolite FM04. It was more druggable because of its improved physicochemical properties. FM04 (EC50 = 83 nM) was 1.8-fold more potent than FD18 in reversing P-glycoprotein (P-gp)-media
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297ab9288971f1e08816d2d7236731c5
https://doi.org/10.3390/ijms232315299
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3
A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer FD18 Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo
Autor: Yunzhe Zhao, Man Chun Law, Tsz Cheung Chong, Kin-Fai Chan, Larry M.C. Chow, Shun Wan Chan, Tak Hang Chan, Jason W. Y. Kan, Clare S. W. Yan, Iris L. K. Wong
Publikováno v: Molecular Pharmaceutics. 12:3507-3517
Flavonoid dimer FD18 is a new class of dimeric P-gp modulator that can reverse cancer drug resistance. FD18 is a potent (EC50 = 148 nM for paclitaxel), safe (selective index = 574), and selective P-glycoprotein (P-gp) modulator. FD18 can modulate mul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc900f3d335ceefd336976a0e34f4f8
https://doi.org/10.1021/mp500770e
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4
Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation
Autor: Kin-Fai Chan, Jason W. Y. Kan, Iris L. K. Wong, Tak Hang Chan, Larry M.C. Chow, Clare S. W. Yan
Publikováno v: Journal of medicinal chemistry. 55(5)
Here we report a great improvement in reversal potency of cancer drug resistance when flavonoid dimers possess a functionally substituted aminopolyethylene glycol linker. The most potent compound, 18, contains a N-benzyl group at the linker. It has m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d6ee59b8af3776985ae77380c3e0cb
https://pubmed.ncbi.nlm.nih.gov/22320402
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5
Design and syntheses of permethyl ningalin B analogues: potent multidrug resistance (MDR) reversal agents of cancer cells
Autor: Tao Jiang, Xiaoyu Zhang, Clare S. W. Yan, Pu Yong Zhang, Iris L. K. Wong, Larry M.C. Chow, Sheng Biao Wan
Publikováno v: Journal of medicinal chemistry. 53(14)
A series of novel N-arylalkyl-3,4-diaryl-substituted pyrrole-2,5-diones were synthesized. They exhibited promising P-gp modulating activity in a P-gp overexpressing breast cancer cell line (LCC6MDR). Compound 6 (with three methoxy groups at D-ring) d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7da2d37293b21fc03b0370d0a83343
https://pubmed.ncbi.nlm.nih.gov/20560605
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6
Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: structure-activity relationships
Autor: Yunzhe Zhao, Kin-Fai Chan, Iris L. K. Wong, Clare S. W. Yan, Toby W. S. Chow, Larry M.C. Chow, Tak Hang Chan, Dik-Lung Ma, Brendan A. Burkett
Publikováno v: ChemMedChem. 4(4)
We recently described the modulatory activities of apigenin homodimers linked by ethylene glycol units in multidrug- resistant breast cancer and leukemic cells overexpressing ABCB1 (P-glycoprotein, P-gp). To further improve the potency of these dimer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a99428e381ce60fbf11b5f4fe912b95
https://pubmed.ncbi.nlm.nih.gov/19288491
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8
Akademický článek
Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel.
Autor: Kan, Jason W. Y.1 (AUTHOR), Yan, Clare S. W.1 (AUTHOR), Wong, Iris L. K.1 (AUTHOR), Su, Xiaochun1 (AUTHOR), Liu, Zhen1 (AUTHOR), Chan, Tak Hang1,2 (AUTHOR) tak-hang.chan@polyu.edu.hk, Chow, Larry M. C.1 (AUTHOR) tak-hang.chan@polyu.edu.hk
Publikováno v: International Journal of Molecular Sciences. Dec2022, Vol. 23 Issue 23, p15299. 26p.
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9
Akademický článek
Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8) 2 , in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2).
Autor: Chong, Tsz Cheung1 (AUTHOR), Wong, Iris L. K.1 (AUTHOR), Cui, Jiahua1,2 (AUTHOR), Law, Man Chun1 (AUTHOR), Zhu, Xuezhen1 (AUTHOR), Hu, Xuesen1 (AUTHOR), Kan, Jason W. Y.1 (AUTHOR), Yan, Clare S. W.1 (AUTHOR), Chan, Tak Hang1,3 (AUTHOR) tak-hang.chan@polyu.edu.hk, Chow, Larry M. C.1 (AUTHOR) tak-hang.chan@polyu.edu.hk
Publikováno v: International Journal of Molecular Sciences. Nov2022, Vol. 23 Issue 21, p13261. 17p.
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