Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Clare R. Harding"'
Autor:
Dana Aghabi, Megan Sloan, Grace Gill, Elena Hartmann, Olga Antipova, Zhicheng Dou, Alfredo J. Guerra, Vern B. Carruthers, Clare R. Harding
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Iron is essential to cells as a cofactor in enzymes of respiration and replication, however without correct storage, iron leads to the formation of dangerous oxygen radicals. In yeast and plants, iron is transported into a membrane-bound vac
Externí odkaz:
https://doaj.org/article/89c46f523ed649f98e1a5c32a5de1964
Autor:
Clare R. Harding, Saima M. Sidik, Boryana Petrova, Nina F. Gnädig, John Okombo, Alice L. Herneisen, Kurt E. Ward, Benedikt M. Markus, Elizabeth A. Boydston, David A. Fidock, Sebastian Lourido
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Artemisinin (ART) resistance poses a problem for malaria elimination. Here, the authors perform genome-wide CRISPR screens in Toxoplasma gondii and identify that the putative transporter Tmem14c and mitochondrial heme metabolism, through mitochondria
Externí odkaz:
https://doaj.org/article/b8df34776e6545b698c1d120fc0d277b
Autor:
Clare R. Harding, Matthew Gow, Joon Ho Kang, Emily Shortt, Scott R. Manalis, Markus Meissner, Sebastian Lourido
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cortical microtubules of Toxoplasma gondii are exceptionally stable, but it isn’t known how they are anchored along membranes. Here, Harding et al. show that GAPM proteins localize to the inner membrane complex and are essential for maintaining the
Externí odkaz:
https://doaj.org/article/766fd260c7ed44caaa4862fd02dabe79
Autor:
Clare R. Harding
Publikováno v:
mSphere, Vol 6, Iss 2 (2021)
Clare Harding works on the metal biology of the parasite Toxoplasma gondii
Externí odkaz:
https://doaj.org/article/f0659a68cf714db8860aef3ed6427016
Publikováno v:
Biochemistry Research International, Vol 2012 (2012)
Leishmania species are the causative agents of the leishmaniases, a spectrum of neglected tropical diseases. Amastigote stage parasites exist within macrophages and scavenge host factors for survival, for example, Leishmania species utilise host sphi
Externí odkaz:
https://doaj.org/article/c8048dee17304afaab60ae43d7e2d785
Publikováno v:
The FEBS Journal. 288:382-404
The Apicomplexa phylum groups important human and animal pathogens that cause severe diseases, encompassing malaria, toxoplasmosis and cryptosporidiosis. In common with most organisms, apicomplexans rely on heme as co‐factor for several enzymes, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9800624e26fa80ee432ec9846d2c421
https://doi.org/10.1111/febs.15445
https://doi.org/10.1111/febs.15445
Publikováno v:
Microbiology (Reading, England)
The acquisition and storage of metals has been a preoccupation of life for millennia. Transition metals, in particular iron, copper and zinc, have vital roles within cells. However, metals also make dangerous cargos; inappropriate uptake or storage o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d51a965a110c373db066e9b4cd8f57
https://doi.org/10.1099/mic.0.001114
https://doi.org/10.1099/mic.0.001114
Autor:
Lilach Sheiner, Jeremy G. Wideman, Christopher J. Tonkin, Marco Biddau, Jana Ovciarikova, Clare R. Harding, Erica S. Martins-Duarte, Alessandro D. Uboldi, Natalia Mallo, Mary-Louise Wilde, Stephan C Baehr, Leandro Lemgruber
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The voltage-dependent anion channel (VDAC) is a ubiquitous channel in the outer membrane of the mitochondrion with multiple roles in protein, metabolite and small molecule transport. In mammalian cells, VDAC protein, as part of a larger complex inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0add26666e4c5cfb8d25225f725f49f5
https://doi.org/10.1242/jcs.255299
https://doi.org/10.1242/jcs.255299
Iron is essential to living cells, acting as a cofactor in a number of essential enzymes in metabolism; however, iron requires proper storage or it can be dangerous to the cell. In both yeast and plants, iron is stored in a vacuole through the action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab555f5155374c0b2b95e5806ab730c1
https://doi.org/10.1101/2021.09.08.458725
https://doi.org/10.1101/2021.09.08.458725
Autor:
Joon Ho Kang, Scott R. Manalis, Emily Shortt, Clare R. Harding, Sebastian Lourido, Markus Meissner, Matthew Gow
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Single-celled protists use elaborate cytoskeletal structures, including arrays of microtubules at the cell periphery, to maintain polarity and rigidity. The obligate intracellular parasite Toxoplasma gondii has unusually stable cortical microtubules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d76ea29a643b2f339fed1c00a6ef01
http://link.springer.com/article/10.1038/s41467-019-08318-7
http://link.springer.com/article/10.1038/s41467-019-08318-7