Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Clare Pacini"'
Autor:
Germán Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M. Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The E3 ubiquitin ligases RNF43/ZNRF3 are often mutated in cancer but their precise contribution to liver disease is unknown. Here, the authors show that RNF43/ZNRF3 alterations predispose to liver cancer by controlling the differentiation and lipid m
Externí odkaz:
https://doaj.org/article/b340f59562d343c38a3ffe78a2def2d3
Autor:
Alessandro Vinceti, Emre Karakoc, Clare Pacini, Umberto Perron, Riccardo Roberto De Lucia, Mathew J. Garnett, Francesco Iorio
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background CRISPR-Cas9 genome-wide screens are being increasingly performed, allowing systematic explorations of cancer dependencies at unprecedented accuracy and scale. One of the major computational challenges when analysing data derived f
Externí odkaz:
https://doaj.org/article/f7df6232fdbd4a2691e1047e936b4957
Autor:
Clare Pacini, Joshua M. Dempster, Isabella Boyle, Emanuel Gonçalves, Hanna Najgebauer, Emre Karakoc, Dieudonne van der Meer, Andrew Barthorpe, Howard Lightfoot, Patricia Jaaks, James M. McFarland, Mathew J. Garnett, Aviad Tsherniak, Francesco Iorio
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The integration of independent pan-cancer CRISPR-Cas9 datasets allows better representation of genomic heterogeneity across different cancer types. Here, the authors propose a strategy for the integration of two large CRISPR-Cas9 screens and report i
Externí odkaz:
https://doaj.org/article/fdd2ad5966004da891cf74b4446afacf
Autor:
Emanuel Gonçalves, Mark Thomas, Fiona M. Behan, Gabriele Picco, Clare Pacini, Felicity Allen, Alessandro Vinceti, Mamta Sharma, David A. Jackson, Stacey Price, Charlotte M. Beaver, Oliver Dovey, David Parry-Smith, Francesco Iorio, Leopold Parts, Kosuke Yusa, Mathew J. Garnett
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract CRISPR guide RNA libraries have been iteratively improved to provide increasingly efficient reagents, although their large size is a barrier for many applications. We design an optimised minimal genome-wide human CRISPR-Cas9 library (MinLibC
Externí odkaz:
https://doaj.org/article/2fa4d024f7b14d10b1fef8e9f3b2d270
Autor:
Emanuel Gonçalves, Aldo Segura‐Cabrera, Clare Pacini, Gabriele Picco, Fiona M Behan, Patricia Jaaks, Elizabeth A Coker, Donny van der Meer, Andrew Barthorpe, Howard Lightfoot, Tatiana Mironenko, Alexandra Beck, Laura Richardson, Wanjuan Yang, Ermira Lleshi, James Hall, Charlotte Tolley, Caitlin Hall, Iman Mali, Frances Thomas, James Morris, Andrew R Leach, James T Lynch, Ben Sidders, Claire Crafter, Francesco Iorio, Stephen Fawell, Mathew J Garnett
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 7, Pp 1-14 (2020)
Abstract Low success rates during drug development are due, in part, to the difficulty of defining drug mechanism‐of‐action and molecular markers of therapeutic activity. Here, we integrated 199,219 drug sensitivity measurements for 397 unique an
Externí odkaz:
https://doaj.org/article/8d3c7a8706894b218dbc302dbd8ec445
Autor:
Joshua M. Dempster, Clare Pacini, Sasha Pantel, Fiona M. Behan, Thomas Green, John Krill-Burger, Charlotte M. Beaver, Scott T. Younger, Victor Zhivich, Hanna Najgebauer, Felicity Allen, Emanuel Gonçalves, Rebecca Shepherd, John G. Doench, Kosuke Yusa, Francisca Vazquez, Leopold Parts, Jesse S. Boehm, Todd R. Golub, William C. Hahn, David E. Root, Mathew J. Garnett, Aviad Tsherniak, Francesco Iorio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Integrating independent large-scale pharmacogenomic screens can enable unprecedented characterization of genetic vulnerabilities in cancers. Here, the authors show that the two largest independent CRISPR-Cas9 gene-dependency screens are concordant, p
Externí odkaz:
https://doaj.org/article/7101cce4933e4a7a88c0656de01f28e5
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-6 (2017)
Abstract Background Correlation matrices are important in inferring relationships and networks between regulatory or signalling elements in biological systems. With currently available technology sample sizes for experiments are typically small, mean
Externí odkaz:
https://doaj.org/article/37892ab638eb4b4c8846baf21d5dc212
Autor:
Emre Karakoc, Umberto Perron, Riccardo Roberto De Lucia, Clare Pacini, Mathew J. Garnett, Francesco Iorio, Alessandro Vinceti
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-16 (2021)
BMC Genomics
BMC Genomics
Background CRISPR-Cas9 genome-wide screens are being increasingly performed, allowing systematic explorations of cancer dependencies at unprecedented accuracy and scale. One of the major computational challenges when analysing data derived from such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8507f5d05470824a97a315f774baf3
https://doaj.org/article/f7df6232fdbd4a2691e1047e936b4957
https://doaj.org/article/f7df6232fdbd4a2691e1047e936b4957
Autor:
Raffaele Iannuzzi, Ichcha Manipur, Clare Pacini, Fiona M. Behan, Mario R. Guarracino, Mathew J. Garnett, Aurora Savino, Francesco Iorio
Genome-wide recessive genetic screens using lentiviral CRISPR-guide RNA libraries are widely performed in mammalian cells to functionally characterise individual genes and for the discovery of new anti-cancer therapeutic targets. As the effectiveness
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67f8955d373925acd92bbc38323d152d
https://doi.org/10.1101/2022.09.23.509258
https://doi.org/10.1101/2022.09.23.509258
Autor:
Emre Karakoc, Hanna Najgebauer, Howard Lightfoot, Mathew J. Garnett, Patricia Jaaks, Emanuel Gonçalves, Clare Pacini, Joshua M. Dempster, Aviad Tsherniak, James M. McFarland, Francesco Iorio, Isabella Boyle, Andrew Barthorpe, Dieudonne van der Meer
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
CRISPR-Cas9 viability screens are increasingly performed at a genome-wide scale across large panels of cell lines to identify new therapeutic targets for precision cancer therapy. Integrating the datasets resulting from these studies is necessary to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beae3fc93e418966fef573c9e8668412
https://doi.org/10.1038/s41467-021-21898-7
https://doi.org/10.1038/s41467-021-21898-7