Výsledky vyhledávání - "Clare Massarella"

Akademický článek

A study protocol to investigate if acipimox improves muscle function and sarcopenia: an open-label, uncontrolled, before-and-after experimental medicine feasibility study in community-dwelling older adults

Autor: Miles D Witham, Lynn Rochester, Charlotte Warren, Laura Brown, Claire McDonald, Silvia Del Din, Kieren Hollingsworth, Craig Alderson, Matthew G Birkbeck, Grainne G Gorman, Clare Massarella, Rana Rehman, Avan AP Sayer, Huizhong Su, Helen Tuppen

Publikováno v: BMJ Open, Vol 14, Iss 2 (2024)

Introduction Sarcopenia is the age-associated loss of muscle mass and strength. Nicotinamide adenine dinucleotide (NAD) plays a central role in both mitochondrial function and cellular ageing processes implicated in sarcopenia. NAD concentrations are

Externí odkaz: https://doaj.org/article/93100a3755a34152b4561225feeb19b5

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Akademický článek

Acipimox in Mitochondrial Myopathy (AIMM): study protocol for a randomised, double-blinded, placebo-controlled, adaptive design trial of the efficacy of acipimox in adult patients with mitochondrial myopathy.

Autor: Abouhajar, Alaa¹ (AUTHOR), Alcock, Lisa² (AUTHOR), Bigirumurame, Theophile³ (AUTHOR), Bradley, Penny⁴ (AUTHOR), Brown, Laura⁵ (AUTHOR), Campbell, Ian⁴ (AUTHOR), Del Din, Sylvia² (AUTHOR), Faitg, Julie⁵ (AUTHOR), Falkous, Gavin⁵ (AUTHOR), Gorman, Gráinne S.^5,6 (AUTHOR), Lakey, Rachel¹ (AUTHOR), McFarland, Robert^5,6 (AUTHOR), Newman, Jane⁵ (AUTHOR), Rochester, Lynn² (AUTHOR), Ryan, Vicky³ (AUTHOR), Smith, Hesther⁴ (AUTHOR), Steel, Alison¹ (AUTHOR), Stefanetti, Renae J.⁵ (AUTHOR), Su, Huizhong⁵ (AUTHOR), Taylor, Robert W.^5,6 (AUTHOR)

Publikováno v: Trials. 9/20/2022, Vol. 23 Issue 1, p1-15. 15p. 1 Diagram, 3 Charts.

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Akademický článek

T cell differentiation drives the negative selection of pathogenic mitochondrial DNA variants.

Autor: Franklin, Imogen G., Milne, Paul, Childs, Jordan, Boggan, Róisín M., Barrow, Isabel, Lawless, Conor, Gorman, Gráinne S., Yi Shiau Ng, Collin, Matthew, Russell, Oliver M., Pickett, Sarah J.

Publikováno v: Life Science Alliance; Nov2023, Vol. 6 Issue 11, p1-15, 15p

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Periodical

Data on Muscular Atrophy Published by Researchers at Newcastle University (A study protocol to investigate if acipimox improves muscle function and sarcopenia: an open-label, uncontrolled, before-and-after experimental medicine feasibility...).

Publikováno v: Clinical Trials Week; 3/11/2024, p648-648, 1p

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