Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Clare M. Waterman"'
Autor:
Myung Hyun Jo, Jing Li, Valentin Jaumouillé, Yuxin Hao, Jessica Coppola, Jiabin Yan, Clare M. Waterman, Timothy A. Springer, Taekjip Ha
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Integrins come in subtypes that bind distinct ligands. This work reveals and quantifies subtype-specific mechanical force transmission and assembly of cytoskeleton architectures.
Externí odkaz:
https://doaj.org/article/8e57f82ed97243da9916234023cd3bb0
Autor:
Patrick Münzer, Roberto Negro, Shoichi Fukui, Lucas di Meglio, Karen Aymonnier, Long Chu, Deya Cherpokova, Sarah Gutch, Nicoletta Sorvillo, Lai Shi, Venkat Giri Magupalli, Alexander N. R. Weber, Rüdiger E. Scharf, Clare M. Waterman, Hao Wu, Denisa D. Wagner
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated by peptidylarginine deimina
Externí odkaz:
https://doaj.org/article/2d05e129ea374b9f8cb826c28431c42d
Autor:
Valentin Jaumouillé, Clare M. Waterman
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Phagocytosis is a specialized process that enables cellular ingestion and clearance of microbes, dead cells and tissue debris that are too large for other endocytic routes. As such, it is an essential component of tissue homeostasis and the innate im
Externí odkaz:
https://doaj.org/article/f8f4b9b5921f4ed3aa48e322d0602272
Autor:
Pontus Nordenfelt, Travis I. Moore, Shalin B. Mehta, Joseph Mathew Kalappurakkal, Vinay Swaminathan, Nobuyasu Koga, Talley J. Lambert, David Baker, Jennifer C. Waters, Rudolf Oldenbourg, Tomomi Tani, Satyajit Mayor, Clare M. Waterman, Timothy A. Springer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here the authors show that actin flow can orient cell surface integrins during leukocyte migration, suggesting integrin activatio
Externí odkaz:
https://doaj.org/article/65af52fbf47f4fb78c2fab61b95611df
Autor:
Komudi Singh, Michelle Baird, Robert Fischer, Vijender Chaitankar, Fayaz Seifuddin, Yun-Ching Chen, Ilker Tunc, Clare M. Waterman, Mehdi Pirooznia
Publikováno v:
Cancers, Vol 12, Iss 2, p 458 (2020)
Melanoma is among the most malignant cutaneous cancers and when metastasized results in dramatically high mortality. Despite advances in high-throughput gene expression profiling in cancer transcriptomic studies, our understanding of mechanisms drivi
Externí odkaz:
https://doaj.org/article/3f94983bc6464aaba63dbb53b6435673
Publikováno v:
Molecular Biology of the Cell
Cancer cells migrating in confined microenvironments exhibit plasticity of migration modes. Confinement of contractile cells in a nonadhesive environment drives “leader bleb–based migration” (LBBM), morphologically characterized by a long bleb
Autor:
Myung Hyun Jo, Jing Li, Valentin Jaumouillé, Yuxin Hao, Jessica Coppola, Jiabin Yan, Clare M. Waterman, Timothy A. Springer, Taekjip Ha
Although integrins are known to be mechano-sensitive and to possess many subtypes that have distinct physiological roles, single molecule studies of force exertion have thus far been limited to RGD-binding integrins. Here, we show that integrin α4β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aae83b8e2810e28e933858ccd3c5b29
https://doi.org/10.1101/2022.06.08.495291
https://doi.org/10.1101/2022.06.08.495291
Autor:
Jessica Wayt, Alexander X. Cartagena-Rivera, Julie G. Donaldson, Clare M. Waterman, Dipannita Dutta
Publikováno v:
Molecular Biology of the Cell
Although the actomyosin cytoskeleton has been implicated in clathrin-mediated endocytosis, a clear requirement for actomyosin in clathrin-independent endocytosis (CIE) has not been demonstrated. We discovered that the Rho-associated kinase ROCK2 is r
Autor:
Jia C Wang, Yang-In Yim, Xufeng Wu, Valentin Jaumouille, Andrew Cameron, Clare M Waterman, John H Kehrl, John A Hammer
Publikováno v:
eLife. 11
B-cell activation and immune synapse (IS) formation with membrane-bound antigens are actin-dependent processes that scale positively with the strength of antigen-induced signals. Importantly, ligating the B-cell integrin, LFA-1, with ICAM-1 promotes
Autor:
Robert D. Goldman, Anne E. Goldman, Rong Qiu, Hawa Racine Thiam, Denisa D. Wagner, Amir Vahabikashi, Clare M. Waterman, Mark Kittisopikul, Siu Ling Wong
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Neutrophils are white blood cells specialized as the first line of host defense in the immune system. One way they protect organisms is through NETosis, in which they expel their DNA to form a web-like trap that ensnares pathogens and pr