Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Clare M Smith"'
Autor:
Clare M Smith, Richard E Baker, Megan K Proulx, Bibhuti B Mishra, Jarukit E Long, Sae Woong Park, Ha-Na Lee, Michael C Kiritsy, Michelle M Bellerose, Andrew J Olive, Kenan C Murphy, Kadamba Papavinasasundaram, Frederick J Boehm, Charlotte J Reames, Rachel K Meade, Brea K Hampton, Colton L Linnertz, Ginger D Shaw, Pablo Hock, Timothy A Bell, Sabine Ehrt, Dirk Schnappinger, Fernando Pardo-Manuel de Villena, Martin T Ferris, Thomas R Ioerger, Christopher M Sassetti
Publikováno v:
eLife, Vol 11 (2022)
The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the pathogen’s ability to adapt to the variable immune pressures exerted by the host. Understanding this interplay has proven difficult, largely because experimentally tra
Externí odkaz:
https://doaj.org/article/22a97844641345f9a6ecfdcfcd9e9300
TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2.
Autor:
Joseph D Trimarco, Brook E Heaton, Ryan R Chaparian, Kaitlyn N Burke, Raquel A Binder, Gregory C Gray, Clare M Smith, Vineet D Menachery, Nicholas S Heaton
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009599 (2021)
Antiviral therapeutics are a front-line defense against virally induced diseases. Because viruses frequently mutate to escape direct inhibition of viral proteins, there is interest in targeting the host proteins that the virus must co-opt to complete
Externí odkaz:
https://doaj.org/article/485cd3cfaf524a5b9fa4517614d1a44a
Autor:
Nuria Martinez, Lorissa J. Smulan, Michael L. Jameson, Clare M. Smith, Kelly Cavallo, Michelle Bellerose, John Williams, Kim West, Christopher M. Sassetti, Amit Singhal, Hardy Kornfeld
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Diabetes mellitus increases risk for tuberculosis disease and adverse outcomes. Most people with both conditions have type 2 diabetes, but it is unknown if type 1 and type 2 diabetes have identical effects on tuberculosis susceptibility. Her
Externí odkaz:
https://doaj.org/article/16bf97a500224871baabf737853f2331
Autor:
Rachel K. Meade, Jarukit E. Long, Adrian Jinich, Kyu Y. Rhee, David G. Ashbrook, Robert W. Williams, Christopher M. Sassetti, Clare M. Smith
Genetic differences among mammalian hosts andMycobacterium tuberculosis(Mtb) strains determine diverse tuberculosis (TB) patient outcomes. The advent of recombinant inbred mouse panels and next-generation transposon mutagenesis and sequencing approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::483dfde763e11ba964eb98a96abf792d
https://doi.org/10.1101/2023.03.05.528534
https://doi.org/10.1101/2023.03.05.528534
Autor:
Joseph W. Saelens, Mollie I. Sweeney, Gopinath Viswanathan, Ana María Xet-Mull, Kristen L. Jurcic Smith, Dana M. Sisk, Daniel D. Hu, Rachel M. Cronin, Erika J. Hughes, W. Jared Brewer, Jörn Coers, Matthew M. Champion, Patricia A. Champion, Craig B. Lowe, Clare M. Smith, Sunhee Lee, Jason E. Stout, David M. Tobin
Publikováno v:
Cell
The human pathogen Mycobacterium tuberculosis typically causes lung disease but can also disseminate to other tissues. We identified a M. tuberculosis (Mtb) outbreak presenting with unusually high rates of extrapulmonary dissemination and bone diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83917a2f0a20514c1f17e7753d9b41f9
https://europepmc.org/articles/PMC9691622/
https://europepmc.org/articles/PMC9691622/
Autor:
Kaley M. Wilburn, Rachel K. Meade, Emma M. Heckenberg, Jacob Dockterman, Jörn Coers, Christopher M. Sassetti, Andrew J. Olive, Clare M. Smith
Mycobacterium tuberculosis(Mtb) is a bacterium that exclusively resides in human hosts and remains a dominant cause of morbidity and mortality among infectious diseases worldwide. Host protection againstMtbinfection is dependent on the function of im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302f35e3919cfd96dec960a48f43bf70
https://doi.org/10.1101/2022.11.09.515519
https://doi.org/10.1101/2022.11.09.515519
Autor:
Tomer M. Yaron, Brook E. Heaton, Tyler M. Levy, Jared L. Johnson, Tristan X. Jordan, Benjamin M. Cohen, Alexander Kerelsky, Ting-Yu Lin, Katarina M. Liberatore, Danielle K. Bulaon, Samantha J. Van Nest, Nikos Koundouros, Edward R. Kastenhuber, Marisa N. Mercadante, Kripa Shobana-Ganesh, Long He, Robert E. Schwartz, Shuibing Chen, Harel Weinstein, Olivier Elemento, Elena Piskounova, Benjamin E. Nilsson-Payant, Gina Lee, Joseph D. Trimarco, Kaitlyn N. Burke, Cait E. Hamele, Ryan R. Chaparian, Alfred T. Harding, Aleksandra Tata, Xinyu Zhu, Purushothama Rao Tata, Clare M. Smith, Anthony P. Possemato, Sasha L. Tkachev, Peter V. Hornbeck, Sean A. Beausoleil, Shankara K. Anand, François Aguet, Gad Getz, Andrew D. Davidson, Kate Heesom, Maia Kavanagh-Williamson, David A. Matthews, Benjamin R. tenOever, Lewis C. Cantley, John Blenis, Nicholas S. Heaton
Publikováno v:
Science signaling, vol 15, iss 757
Multiple coronaviruses have emerged independently in the past 20 years that cause lethal human diseases. Although vaccine development targeting these viruses has been accelerated substantially, there remain patients requiring treatment who cannot be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f52febef82f67d02ed9c0d55e48f84
https://escholarship.org/uc/item/44d513nc
https://escholarship.org/uc/item/44d513nc
Genome-wide random mutagenesis screens using transposon sequencing (TnSeq) have been a cornerstone of functional genetics inMycobacterium tuberculosis(Mtb), helping to define gene essentiality across a wide range of experimental conditions. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab9c46c03504a4fbb4edba4a85c6ca99
https://doi.org/10.1101/2022.09.27.509804
https://doi.org/10.1101/2022.09.27.509804
Publikováno v:
Trends Microbiol
Humanity's ongoing struggle with new, re-emerging and endemic infectious diseases serves as a frequent reminder of the need to understand host-pathogen interactions. Recent advances in genomics have dramatically advanced our understanding of how gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea7749ad22d207175e923a9564d2e30
https://doi.org/10.1016/j.tim.2020.09.006
https://doi.org/10.1016/j.tim.2020.09.006
Autor:
Rustin R. Lovewell, Christina E. Baer, Christopher M. Sassetti, Bibhuti B. Mishra, Clare M. Smith
Publikováno v:
Mucosal immunology
Granulocyte recruitment to the pulmonary compartment is a hallmark of progressive tuberculosis (TB). This process is well-documented to promote immunopathology, but can also enhance the replication of the pathogen. Both the specific granulocytes resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e013aeb9a078969080c1f0b0d32c757
https://doi.org/10.1038/s41385-020-0300-z
https://doi.org/10.1038/s41385-020-0300-z