Zobrazeno 1 - 10 of 70 pro vyhledávání: '"Clare L. Bennett"'
1
Akademický článek
Impaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis
Autor: Sofia Sirvent, Andres F. Vallejo, Emma Corden, Ying Teo, James Davies, Kalum Clayton, Eleanor G. Seaby, Chester Lai, Sarah Ennis, Rfeef Alyami, Gemma Douilhet, Lareb S. N. Dean, Matthew Loxham, Sarah Horswill, Eugene Healy, Graham Roberts, Nigel J. Hall, Peter S. Friedmann, Harinder Singh, Clare L. Bennett, Michael R Ardern-Jones, Marta E. Polak
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Regulation of cutaneous immunity is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic dermatitis, we utilise a human in vivo allergen challenge stud
Externí odkaz: https://doaj.org/article/8a9e3b6f395949309fb497cf8ddaabc0
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2
Akademický článek
Executable network of SARS-CoV-2-host interaction predicts drug combination treatments
Autor: Rowan Howell, Matthew A. Clarke, Ann-Kathrin Reuschl, Tianyi Chen, Sean Abbott-Imboden, Mervyn Singer, David M. Lowe, Clare L. Bennett, Benjamin Chain, Clare Jolly, Jasmin Fisher
Publikováno v: npj Digital Medicine, Vol 5, Iss 1, Pp 1-13 (2022)
Abstract The COVID-19 pandemic has pushed healthcare systems globally to a breaking point. The urgent need for effective and affordable COVID-19 treatments calls for repurposing combinations of approved drugs. The challenge is to identify which combi
Externí odkaz: https://doaj.org/article/138f70666aaf4bca914664c7e630f7d8
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3
Akademický článek
Loss of T cell tolerance in the skin following immunopathology is linked to failed restoration of the dermal niche by recruited macrophages
Autor: Heather C. West, James Davies, Stephen Henderson, Oluyori K. Adegun, Sophie Ward, Ivana R. Ferrer, Chanidapa A. Tye, Andres F. Vallejo, Laura Jardine, Matthew Collin, Marta E. Polak, Clare L. Bennett
Publikováno v: Cell Reports, Vol 39, Iss 7, Pp 110819- (2022)
Summary: T cell pathology in the skin leads to monocyte influx, but we have little understanding of the fate of recruited cells within the diseased niche, or the long-term impact on cutaneous immune homeostasis. By combining a murine model of acute g
Externí odkaz: https://doaj.org/article/960eba7bb8e8431f8c5a9ff4e7e81b08
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5
Akademický článek
Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease
Autor: Pedro Santos e Sousa, Clare L. Bennett, Ronjon Chakraverty
Publikováno v: Frontiers in Immunology, Vol 9 (2018)
The skin is the most common target organ affected by graft-versus-host disease (GVHD), with severity and response to therapy representing important predictors of patient survival. Although many of the initiating events in GVHD pathogenesis have been
Externí odkaz: https://doaj.org/article/297c024adbd84d8aa56ca78a34f3130a
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6
Akademický článek
Redefining the Role of Langerhans Cells As Immune Regulators within the Skin
Autor: Heather C. West, Clare L. Bennett
Publikováno v: Frontiers in Immunology, Vol 8 (2018)
Langerhans cells (LC) are a unique population of tissue-resident macrophages that form a network of cells across the epidermis of the skin, but which have the ability to migrate from the epidermis to draining lymph nodes (LN). Their location at the s
Externí odkaz: https://doaj.org/article/adaef36c4429412f91f1c7439c05d560
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