Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Clare L Parish"'
Autor:
Matthew J Bird, Karina Needham, Ann E Frazier, Jorien van Rooijen, Jessie Leung, Shelley Hough, Mark Denham, Matthew E Thornton, Clare L Parish, Bryony A Nayagam, Martin Pera, David R Thorburn, Lachlan H Thompson, Mirella Dottori
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101718 (2014)
Friedreich ataxia (FRDA) is an autosomal recessive disease characterised by neurodegeneration and cardiomyopathy that is caused by an insufficiency of the mitochondrial protein, frataxin. Our previous studies described the generation of FRDA induced
Externí odkaz:
https://doaj.org/article/ed897e14d7e74829a1c23656b9e1c562
Autor:
Clare L Parish, Lachlan eThompson
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 7 (2013)
Externí odkaz:
https://doaj.org/article/af49f589ca7649e0b34024fb083c1296
Autor:
Michael M Halford, Maria L Macheda, Clare L Parish, Elena A Takano, Stephen Fox, Daniel Layton, Edouard Nice, Steven A Stacker
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75447 (2013)
RYK is an unusual member of the receptor tyrosine kinase (RTK) family that is classified as a putative pseudokinase. RYK regulates fundamental biological processes including cell differentiation, migration and target selection, axon outgrowth and pat
Externí odkaz:
https://doaj.org/article/ea185b217d6047a2890c848bb18c3f44
Autor:
Mark eDenham, Clare L Parish, Bryan eLeaw, Jordan eWright, Christopher A Reid, Steven ePetrou, Mirella eDottori, Lachlan H Thompson
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 6 (2012)
Human pluripotent stem cells have the capacity for directed differentiation into a wide variety of neuronal subtypes that may be useful for brain repair. While a substantial body of research has lead to a detailed understanding of the ability of neur
Externí odkaz:
https://doaj.org/article/9a07dce136f24e40860dc235d55391db
Autor:
Brette D Blakely, Christopher R Bye, Chathurini V Fernando, Malcolm K Horne, Maria L Macheda, Steven A Stacker, Ernest Arenas, Clare L Parish
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18373 (2011)
During development, precise temporal and spatial gradients are responsible for guiding axons to their appropriate targets. Within the developing ventral midbrain (VM) the cues that guide dopaminergic (DA) axons to their forebrain targets remain to be
Externí odkaz:
https://doaj.org/article/ea38d9ffb4af4b8f8612bfd5fd0c9afe
Autor:
Jan Tønnesen, Clare L Parish, Andreas T Sørensen, Angelica Andersson, Cecilia Lundberg, Karl Deisseroth, Ernest Arenas, Olle Lindvall, Merab Kokaia
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17560 (2011)
Intrastriatal grafts of stem cell-derived dopamine (DA) neurons induce behavioral recovery in animal models of Parkinson's disease (PD), but how they functionally integrate in host neural circuitries is poorly understood. Here, Wnt5a-overexpressing n
Externí odkaz:
https://doaj.org/article/178f0db09e12429284cba92c549326b7
Autor:
Negar Mahmoudi, Elmira Mohamed, Shiva Soltani Dehnavi, Lilith M. Caballero Aguilar, Alan R. Harvey, Clare L. Parish, Richard J. Williams, David R. Nisbet
Publikováno v:
Advanced Science, Vol 11, Iss 5, Pp n/a-n/a (2024)
Abstract Current therapies for the devastating damage caused by traumatic brain injuries (TBI) are limited. This is in part due to poor drug efficacy to modulate neuroinflammation, angiogenesis and/or promoting neuroprotection and is the combined res
Externí odkaz:
https://doaj.org/article/e392cbe07a204a6185db60922a26a4fb
Autor:
Yupei You, Yair D. J. Prawer, Ricardo De Paoli-Iseppi, Cameron P. J. Hunt, Clare L. Parish, Heejung Shim, Michael B. Clark
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Long-read single-cell RNA sequencing (scRNA-seq) enables the quantification of RNA isoforms in individual cells. However, long-read scRNA-seq using the Oxford Nanopore platform has largely relied upon matched short-read data to identify cell
Externí odkaz:
https://doaj.org/article/a4ff70579435468daf852b4038d442a4
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102325- (2023)
Summary: High-throughput imaging allows in vitro assessment of neuron morphology for screening populations under developmental, homeostatic, and/or disease conditions. Here, we present a protocol to differentiate cryopreserved human cortical neuronal
Externí odkaz:
https://doaj.org/article/9d2a0e230faa47f3ac875665ccb5c021
Autor:
Isabelle R. de Luzy, Kevin C. L. Law, Niamh Moriarty, Cameron P. J. Hunt, Jennifer C. Durnall, Lachlan H. Thompson, Andras Nagy, Clare L. Parish
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Stem cell grafts present a risk of tissue overgrowth/tumors. Here, the authors utilise a human pluripotent stem cell line carrying a FailSafe suicide gene to not only ablate proliferative cells, but through timely gene activation, improve the purity
Externí odkaz:
https://doaj.org/article/ca572aff55e041bfa62cd27bc82d3238