Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?

Autor: Fahd O Ismael, Tessa J Barrett, Diba Sheipouri, Bronwyn E Brown, Michael J Davies, Clare L Hawkins

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0168844 (2016)

Low-density lipoprotein (LDL) is the major source of lipid within atherosclerotic lesions. Myeloperoxidase (MPO) is present in lesions and forms the reactive oxidants hypochlorous acid (HOCl) and hypothiocyanous acid (HOSCN). These oxidants modify LD

Externí odkaz: https://doaj.org/article/5154712134ee493eac4de4dae36a5460

Identification and quantification of protein nitration sites in human coronary artery smooth muscle cells in the absence and presence of peroxynitrous acid/peroxynitrite

Autor: Shuqi Xu, Christine Y. Chuang, Clare L. Hawkins, Per Hägglund, Michael J. Davies

Publikováno v: Redox Biology, Vol 64, Iss , Pp 102799- (2023)

Peroxynitrous acid/peroxynitrite (ONOOH/ONOO−) is a powerful oxidizing/nitrating system formed at sites of inflammation, which can modify biological targets, and particularly proteins. Here, we show that multiple proteins from primary human coronar

Externí odkaz: https://doaj.org/article/813830b3da5440e98dce6d4e09bfdb9a

Hypochlorous Acid and Chloramines Induce Specific Fragmentation and Cross-Linking of the G1-IGD-G2 Domains of Recombinant Human Aggrecan, and Inhibit ADAMTS1 Activity

Autor: Yihe Wang, Astrid Hammer, Gerald Hoefler, Ernst Malle, Clare L. Hawkins, Christine Y. Chuang, Michael J. Davies

Publikováno v: Antioxidants, Vol 12, Iss 2, p 420 (2023)

Atherosclerosis is a chronic inflammatory disease and a leading cause of mortality. It is characterized by arterial wall plaques that contain high levels of cholesterol and other lipids and activated leukocytes covered by a fibrous cap of extracellul

Externí odkaz: https://doaj.org/article/697fa4c76067437d8970143c3ef93646

New insight into the composition of extracellular traps released by macrophages exposed to different types of inducers

Autor: Mathias Jensen, Nicoline W. Thorsen, Line A.E. Hallberg, Per Hägglund, Clare L. Hawkins

Publikováno v: Jensen, M, Thorsen, N W, Hallberg, L A E, Hägglund, P & Hawkins, C L 2023, ' New insight into the composition of extracellular traps released by macrophages exposed to different types of inducers ', Free Radical Biology and Medicine, vol. 202, pp. 97-109 . https://doi.org/10.1016/j.freeradbiomed.2023.03.025

Neutrophil extracellular trap (NET) release plays a key role in many chronic disease settings, including atherosclerosis. They are critical to innate immune defence, but also contribute to disease by promoting thrombosis and inflammation. Macrophages

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e1852ba5415caca775c1756afcadda
https://doi.org/10.1016/j.freeradbiomed.2023.03.025

Myeloperoxidase-derived damage to human plasma fibronectin: Modulation by protein binding and thiocyanate ions (SCN−)

Autor: Siriluck Vanichkitrungruang, Christine Y. Chuang, Clare L. Hawkins, Michael J. Davies

Publikováno v: Redox Biology, Vol 36, Iss , Pp 101641- (2020)

Endothelial cell dysfunction is an early event in cardiovascular disease and atherosclerosis. The origin of this dysfunction is unresolved, but accumulating evidence implicates damaging oxidants, including hypochlorous acid (HOCl), a major oxidant pr

Externí odkaz: https://doaj.org/article/07b37067fc3a42d785b73c44e07abb73