Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Clare F. Malone"'
Autor:
Clare F. Malone, Minjee Kim, Gabriela Alexe, Kathleen Engel, Alexandra B. Forman, Amanda Robichaud, Amy Saur Conway, Amy Goodale, Ashleigh Meyer, Delan Khalid, Allen Thayakumar, John M. Hatcher, Nathanael S. Gray, Federica Piccioni, Kimberly Stegmaier
Publikováno v:
Cancer Research. 83:285-300
Aberrant RAS/MAPK signaling is a common driver of oncogenesis that can be therapeutically targeted with clinically approved MEK inhibitors. Disease progression on single-agent MEK inhibitors is common, however, and combination therapies are typically
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
NXT2 expression is associated with NXT1 dependency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b3b0cf92ac2514acd3f0a02dca1932
https://doi.org/10.1158/2159-8290.22539455.v1
https://doi.org/10.1158/2159-8290.22539455.v1
Autor:
Karen Cichowski, Rachel Ingraham, Thomas DeRaedt, Ophélia Maertens, Jody A. Fromm, Clare F. Malone
PDF file - 107KB, Two class comparison between combination treated samples and controls for the other GLUT proteins and hexokinses. The log2 of fold (combination/control) expression for each gene in the GLUT and hexokinase family are shown, such that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a137c478af970946590ce8f1b47010af
https://doi.org/10.1158/2159-8290.22532282
https://doi.org/10.1158/2159-8290.22532282
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
CRISPR guide sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f5c15a72ce13e9594b29f8a9df403d
https://doi.org/10.1158/2159-8290.22539446.v1
https://doi.org/10.1158/2159-8290.22539446.v1
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
Differential NXT2 expression in neuroblastoma cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48596ce6d85a7becb6ded4f53a2dd34a
https://doi.org/10.1158/2159-8290.22539452.v1
https://doi.org/10.1158/2159-8290.22539452.v1
Autor:
Karen Cichowski, Rachel Ingraham, Thomas DeRaedt, Ophélia Maertens, Jody A. Fromm, Clare F. Malone
PDF file - 47KB, Supplementary Figure 1 shows that AKT inhibition does not slow proliferation in a human MPNST cell line.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5cd4d26a5895bc0c82b7e59e7813c8
https://doi.org/10.1158/2159-8290.22532291.v1
https://doi.org/10.1158/2159-8290.22532291.v1
Autor:
Karen Cichowski, Ophélia Maertens, Kay F. Macleod, Marcia Haigis, Franziska Michor, Lin L. Liu, Haejin Yoon, Stephanie Guerra, William Barbosa, Rachel Ingraham, Chloe Emerson, Clare F. Malone
Supplementary Figure S1. MPNSTs are sensitive to combined HDAC and mTOR inhibtion; Supplementary Figure S2. Change in animal weight while on combiniation treatment; Supplementary Figure S3. A) 90-8TL cells were treated with Nexturastat A at concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77429da6832c765bb80a567d418a598a
https://doi.org/10.1158/2159-8290.22532905
https://doi.org/10.1158/2159-8290.22532905
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
NXT1 is a selective and lethal dependency in neuroblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c007b460f4affa6e191fd02da49f312
https://doi.org/10.1158/2159-8290.22539461
https://doi.org/10.1158/2159-8290.22539461
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
NXT2 expression is not associated with neuroblastoma disease subtypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9cf9888fe1dbf41f41b0f00cae68372
https://doi.org/10.1158/2159-8290.22539449
https://doi.org/10.1158/2159-8290.22539449
Autor:
Karen Cichowski, Rachel Ingraham, Thomas DeRaedt, Ophélia Maertens, Jody A. Fromm, Clare F. Malone
PDF file - 75KB, Reported in vitro isoform specificities of PI3K inhibitors. The IC50 (nM) reported in the literature for each PI3K inhibitor against Class IA catalytic isoforms in in vitro binding assays is shown. The source for each data set is lis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122105ab0f38d156f0667f45d160d388
https://doi.org/10.1158/2159-8290.22532285.v1
https://doi.org/10.1158/2159-8290.22532285.v1