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pro vyhledávání: '"Clare E. Murray"'
Autor:
Anand V.R. Kornepati, Jacob T. Boyd, Clare E. Murray, Julia Saifetiarova, Bárbara de la Peña Avalos, Cody M. Rogers, Haiyan Bai, Alvaro S. Padron, Yiji Liao, Carlos Ontiveros, Robert S. Svatek, Robert Hromas, Rong Li, Yanfen Hu, Jose R. Conejo-Garcia, Ratna K. Vadlamudi, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J. Curiel
Publikováno v:
Cancer Res
BRCA1-mediated homologous recombination is an important DNA repair mechanism that is the target of FDA-approved PARP inhibitors, yet details of BRCA1-mediated functions remain to be fully elucidated. Similarly, immune checkpoint molecules are targets
Autor:
Harshita B. Gupta, Clare E Murray, June Deng, Tabrez AS Mohammad, Xinyue Zhang, Bogang Wu, Curtis A Clark, Gangadhara Sareddy, Yidong Chen, Ratna Vadlamudi, Rong Li, Tyler J Curiel
Publikováno v:
The Journal of Immunology. 202:195.29-195.29
We reported that tumor intrinsic PD-L1 promotes tumor initiating cell (TIC) virulence and mTORC1. Others have focused on PI3K/AKT/mTOR in promoting TIC, but specific downstream mTOR regulators of tumor stemness are unknown. We knocked down Raptor (mT