Výsledky vyhledávání - "Clare E. Lee"

The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition

Autor: Emily J. Parker, T.V.M. Cookson, Clare E. Lee, Edward N. Baker, Alina Castell, Francesca L. Short, Dmitri D. A. Joseph, Genevieve L. Evans, Esther M. M. Bulloch, J. Shaun Lott

Publikováno v: Biochemistry. 52:1776-1787

Anthranilate phosphoribosyltransferase (AnPRT, EC 2.4.2.18) is a homodimeric enzyme that catalyzes the reaction between 5'-phosphoribosyl 1'-pyrophosphate (PRPP) and anthranilate, as part of the tryptophan biosynthesis pathway. Here we present the re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841e6ab4bf400683263695f8c44232f9
https://doi.org/10.1021/bi301387m

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The Crystal Structure of TrpD, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate

Autor: Clare E. Lee, Edward N. Baker, Farah Javid-Majd, J. Shaun Lott, Catherine E. Goodfellow

Publikováno v: Journal of Molecular Biology. 355:784-797

Mycobacterium tuberculosis , the cause of tuberculosis, presents a major threat to human health worldwide. Biosynthetic enzymes that are essential for the survival of the bacterium, especially in activated macrophages, are important potential drug ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f10a761f38fe98befd3d3a8da43598
https://doi.org/10.1016/j.jmb.2005.11.016

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