Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Clare E Bryant"'
Publikováno v:
eLife, Vol 13 (2024)
The Myddosome is a key innate immune signalling platform. It forms at the cell surface and contains MyD88 and IRAK proteins which ultimately coordinate the production of pro-inflammatory cytokines. Toll-like receptor 4 (TLR4) signals via the Myddosom
Externí odkaz:
https://doaj.org/article/b76978eda61a4ecdb0f52488d69b4180
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282843 (2023)
Streptococcus pneumoniae is an important cause of fatal pneumonia in humans. These bacteria express virulence factors, such as the toxins pneumolysin and autolysin, that drive host inflammatory responses. In this study we confirm loss of pneumolysin
Externí odkaz:
https://doaj.org/article/d077cbcb7aed406297989b789ccce70e
Autor:
Sarah Louise Latty, Jiro Sakai, Lee Hopkins, Brett Verstak, Teresa Paramo, Nils A Berglund, Eugenia Cammarota, Pietro Cicuta, Nicholas J Gay, Peter J Bond, David Klenerman, Clare E Bryant
Publikováno v:
eLife, Vol 7 (2018)
Infection and tissue damage induces assembly of supramolecular organizing centres (SMOCs)), such as the Toll-like receptor (TLR) MyDDosome, to co-ordinate inflammatory signaling. SMOC assembly is thought to drive digital all-or-none responses, yet TL
Externí odkaz:
https://doaj.org/article/ec0354b0493a40a8bfcede70576b1981
Autor:
Katherine L Irvine, Monique Gangloff, Catherine M Walsh, David R Spring, Nicholas J Gay, Clare E Bryant
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98776 (2014)
The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4) are well understood, but how activation is induced by other lipid A species is less clear. Species specificity
Externí odkaz:
https://doaj.org/article/13ede64a73ed4e5ba60ec18caeaacca7
Autor:
Georgina L Hold, Susan Berry, Karin A Saunders, Janice Drew, Claus Mayer, Heather Brookes, Nick J Gay, Emad M El-Omar, Clare E Bryant
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111460 (2014)
Dysregulated Toll-Like Receptor (TLR) signalling and genetic polymorphisms in these proteins are linked to many human diseases. We investigated TLR4 functional variants D299G and T399I to assess the impact on LPS-induced responsiveness in comparison
Externí odkaz:
https://doaj.org/article/00f6564b2db24b8cae4420cc91841f22
Autor:
Nazila V Jafari, Sarah A Kuehne, Clare E Bryant, Mamoun Elawad, Brendan W Wren, Nigel P Minton, Elaine Allan, Mona Bajaj-Elliott
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69846 (2013)
Clostridium difficile infection (CDI) is the leading cause of hospital and community-acquired antibiotic-associated diarrhoea and currently represents a significant health burden. Although the role and contribution of C. difficile toxins to disease p
Externí odkaz:
https://doaj.org/article/4099a747f97d483ab9ffc5b35212b8c4
Autor:
Laura Weimann, Kristina A Ganzinger, James McColl, Kate L Irvine, Simon J Davis, Nicholas J Gay, Clare E Bryant, David Klenerman
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64287 (2013)
Single-particle tracking (SPT) is widely used to study processes from membrane receptor organization to the dynamics of RNAs in living cells. While single-dye labeling strategies have the benefit of being minimally invasive, this comes at the expense
Externí odkaz:
https://doaj.org/article/4320fa141aa94701811e0dd120cf10e0
Autor:
Mashael S Al-Mutairi, Laurence C Cadalbert, H Adrienne McGachy, Muhannad Shweash, Juliane Schroeder, Magdalena Kurnik, Callum M Sloss, Clare E Bryant, James Alexander, Robin Plevin
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001192 (2010)
In this study we generated a novel dual specific phosphatase 4 (DUSP4) deletion mouse using a targeted deletion strategy in order to examine the role of MAP kinase phosphatase-2 (MKP-2) in immune responses. Lipopolysaccharide (LPS) induced a rapid, t
Externí odkaz:
https://doaj.org/article/8b370344e4b845929912de640584ece4
Autor:
Ricardo Núñez Miguel, Joyce Wong, Julian F Westoll, Heather J Brooks, Luke A J O'Neill, Nicholas J Gay, Clare E Bryant, Tom P Monie
Publikováno v:
PLoS ONE, Vol 2, Iss 8, p e788 (2007)
The Toll-like receptor 4 (TLR4) is a class I transmembrane receptor expressed on the surface of immune system cells. TLR4 is activated by exposure to lipopolysaccharides derived from the outer membrane of Gram negative bacteria and forms part of the
Externí odkaz:
https://doaj.org/article/079e7fe1244f4808a5ecec4901e95213
Autor:
Clinton J. Bradfield, Jonathan J. Liang, Orna Ernst, Sinu P. John, Jing Sun, Sundar Ganesan, Adriana A. de Jesus, Clare E. Bryant, Raphaela Goldbach-Mansky, Iain D. C. Fraser
Publikováno v:
Cell Death & Differentiation. 30:589-604