Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Clare E, Hughes"'
Publikováno v:
Physiological Reports, Vol 11, Iss 15, Pp n/a-n/a (2023)
Abstract The circadian clock, a collection of endogenous cellular oscillators with an approximate 24‐h cycle, involves autoregulatory transcriptional/translational feedback loops to enable synchronization within the body. Circadian rhythmicity is c
Externí odkaz:
https://doaj.org/article/7266b9eb66384096b7261e45bf1deb30
Autor:
Kiranjit K. Bains, Sean Ashworth, Elena Koudouna, Robert D. Young, Clare E. Hughes, Andrew J. Quantock
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2095 (2023)
Chondroitin sulphate (CS) proteoglycans with variable sulphation-motifs along their glycosaminoglycan (GAG) chains are closely associated with the stem cell niche of articular cartilage, where they are believed to influence the characteristics of the
Externí odkaz:
https://doaj.org/article/ff61a21a858b40548f4595a8fd80ea71
Autor:
Sean Ashworth, Jodie Harrington, Greg M. Hammond, Kiranjit K. Bains, Elena Koudouna, Anthony J. Hayes, James R. Ralphs, Justyn W. Regini, Robert D. Young, Ryuhei Hayashi, Kohji Nishida, Clare E. Hughes, Andrew J. Quantock
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Chondroitin sulfate (CS) is an important component of the extracellular matrix in multiple biological tissues. In cornea, the CS glycosaminoglycan (GAG) exists in hybrid form, whereby some of the repeating disaccharides are dermatan sulfate (DS). The
Externí odkaz:
https://doaj.org/article/db9fa5bfb8664e638206b5dd82603a35
Autor:
Jinghong, Chen, Mingxiu, Luo, Wei, Wang, Zentie, Zhang, Ying, He, Victor C, Duance, Clare E, Hughes, Bruce, Caterson, Junling, Cao
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 33(1)
Kashin-Beck disease (KBD) is a chronic, deforming endemic osteoarticular disease with altered metabolism of the cartilage matrix. Matrix metalloproteinases (MMPs), aggrecanases (ATAMTSs), and their inhibitors (TIMPs) play important roles in cartilage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c9193c49d9b66c62a5467d55c46052b
https://pubmed.ncbi.nlm.nih.gov/25263345
https://pubmed.ncbi.nlm.nih.gov/25263345
Publikováno v:
Arthritis Research & Therapy
There is an increasing body of evidence that synovitis plays a role in the progression of osteoarthritis and that overproduction of cytokines and growth factors from the inflamed synovium can influence the production of degradative enzymes and the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ac57968e61000c40c2510aa5114f9cea
https://pubmed.ncbi.nlm.nih.gov/17177994
https://pubmed.ncbi.nlm.nih.gov/17177994
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 225
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0677f79f7901298a80441a5552fcb1e8
https://pubmed.ncbi.nlm.nih.gov/12769477
https://pubmed.ncbi.nlm.nih.gov/12769477
Autor:
Chris B, Little, Clare E, Hughes, Clare L, Curtis, Simon A, Jones, Bruce, Caterson, Carl R, Flannery
Publikováno v:
Arthritis and rheumatism. 46(1)
To determine the effect of cyclosporin A (CSA) on aggrecanase- and matrix metalloproteinase (MMP)-mediated catabolism of proteoglycan (aggrecan) in articular cartilage explants stimulated with interleukin-1 (IL-1) in a culture system that mimics earl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c45dbebf285e84d71927eb2e9d6cf5a
https://pubmed.ncbi.nlm.nih.gov/11817583
https://pubmed.ncbi.nlm.nih.gov/11817583