Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Clare E, Gallon"'
Publikováno v:
Journal of Molecular Biology. 425:1565-1581
The cardiac muscle comprises dynamically interacting components that use allosteric/cooperative mechanisms to yield unique heart-specific properties. An essential protein in this allosteric/cooperative mechanism is cardiac muscle troponin T (cTnT), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7364ec2325741f2c9e35db3d6498534f
https://doi.org/10.1016/j.jmb.2013.01.028
https://doi.org/10.1016/j.jmb.2013.01.028
Autor:
Andrew E. Messer, Adam Jacques, Clare E. Gallon, Cristobal G. dos Remedios, Steven B. Marston, Christopher R. Bayliss, Charles Redwood, O'Neal Copeland, Man-Ching Leung, William J. McKenna, Douglas G. Ward
Publikováno v:
Cardiovascular Research
Cardiovascular Research; Vol 97
Cardiovascular Research; Vol 97
AIMS: We studied the relationship between myofilament Ca(2+) sensitivity and troponin I (TnI) phosphorylation by protein kinase A at serines 22/23 in human heart troponin isolated from donor hearts and from myectomy samples from patients with hypertr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cdae478b45f75452d02d0879c3c3fec
https://ora.ox.ac.uk/objects/uuid:6a4c5515-82ba-4813-98d8-1c82b19966d8
https://ora.ox.ac.uk/objects/uuid:6a4c5515-82ba-4813-98d8-1c82b19966d8
Autor:
Steven B. Marston, Clare E. Gallon, Adam Jacques, Victor Tsang, Andrew E. Messer, O'Neal Copeland, William J. McKenna, Katie King
Publikováno v:
Journal of Molecular and Cellular Cardiology. 45:209-216
Phosphorylation of myosin binding protein C (MyBP-C) was investigated in intraventricular septum samples taken from patients with hypertrophic cardiomyopathy undergoing surgical septal myectomy. These samples were compared with donor heart muscle, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62de5cc3969623de4415c1a8e0b50af7
https://doi.org/10.1016/j.yjmcc.2008.05.020
https://doi.org/10.1016/j.yjmcc.2008.05.020
Autor:
S. Victor Perry, Clare E. Gallon, Abdellatif Fattoum, Barry A. Levine, Matthew A. Hodgkin, Valerie B. Patchell
Publikováno v:
European Journal of Biochemistry. 269:5088-5100
Peptides corresponding to the N-terminus of skeletal myosin light chain 1 (rsMLC1 1–37) and the short loop of human cardiac β-myosin (hcM398–414) have been shown to interact with skeletal F-actin by NMR and fluorescence measurements. Skeletal tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::727479e5ee0800baf860972e42364d60
https://doi.org/10.1046/j.1432-1033.2002.03227.x
https://doi.org/10.1046/j.1432-1033.2002.03227.x
Autor:
Steven B. Marston, Andrew E. Messer, Douglas G. Ward, Anita C. Hoskins, Jonathan C. Kentish, Clare E. Gallon, Michael Burch, Emma C. Dyer, Adam Jacques, Juan Pablo Kaski
Publikováno v:
U101
Background— Familial dilated cardiomyopathy can be caused by mutations in the proteins of the muscle thin filament. In vitro, these mutations decrease Ca 2+ sensitivity and cross-bridge turnover rate, but the mutations have not been investigated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947bfb545174ae63615a9dac57fcdb9c
http://hdl.handle.net/10044/1/19193
http://hdl.handle.net/10044/1/19193
Autor:
Steven B. Marston, William J. McKenna, Clare E. Gallon, Cristobal G. dos Remedios, Andrew E. Messer
Publikováno v:
Proteomics. Clinical applications. 3(12)
We have used phosphate affinity SDS-PAGE to separate the phosphorylated species of cardiac troponin I (cTnI). To test the method we phosphorylated pure cTnI with protein kinase A catalytic subunit and observed up to six bands corresponding to 0, 1P,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92bb452af8886295edc2b8066787180
https://pubmed.ncbi.nlm.nih.gov/21136957
https://pubmed.ncbi.nlm.nih.gov/21136957
Publikováno v:
Biophysical Journal. 96(3)
Recently, we have used phosphate-affinity SDS-PAGE gels containing Phos-tag-acrylamide (a phosphate-chelating molecule), to determine the level of cardiac troponin I (cTnI) phosphorylation in human myofibrillar extracts. The Phos-tag moiety binds to,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdbe874caff940995a5f7a5216fa762
Autor:
Clare E. Gallon
Publikováno v:
Journal of muscle research and cell motility. 29(6-8)
Cardiac troponin I phosphorylation has been shown to be reduced in human heart failure and hypertrophic cardiomyopathy using the increasingly popular Pro-Q Diamond phosphoprotein gel stain. In this brief report I discuss the use of Western immunoblot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c072f26d61877babd959a7cc56647c5e
https://pubmed.ncbi.nlm.nih.gov/19172403
https://pubmed.ncbi.nlm.nih.gov/19172403
Autor:
Steven B. Marston, G Kikonda-Kanda, S Jalilzadeh, Sian E. Harding, J Goddard, Esteban, N Briceno, Victor Tsang, Andrew E. Messer, William J. McKenna, Edwin Garcia, Hugh Watkins, Clare E. Gallon, Adam Jacques
Publikováno v:
Cardiovascular Research
AIM: The aim of the study was to compare the functional and structural properties of the motor protein, myosin, and isolated myocyte contractility in heart muscle excised from hypertrophic cardiomyopathy patients by surgical myectomy with explanted f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07db8880c0aeb8c6eb4b4ed999e25f17
https://pubmed.ncbi.nlm.nih.gov/18411228
https://pubmed.ncbi.nlm.nih.gov/18411228
Publikováno v:
Archives of biochemistry and biophysics. 456(2)
The carboxy terminus of fast skeletal muscle troponin T (fsTnT) is highly conserved. However, mutually exclusive splicing of exons 16 and 17 in the fsTnT gene results in the expression of either the alpha- or beta-fsTnT isoform. The alpha-isoform is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da4ed472e3175864cc8d42676ede904
https://pubmed.ncbi.nlm.nih.gov/16839517
https://pubmed.ncbi.nlm.nih.gov/16839517