Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Clare D. Hammond"'
Autor:
Frederick W. Goldberg, Alan Martin Birch, Andrew G. Leach, Wendy L. Snelson, Linda K. Buckett, Sam D. Groombridge, Pablo Morentin Gutierrez, Susan Birtles, Clare D. Hammond
Publikováno v:
MedChemComm. 4:165-174
A series of neutral DGAT1 inhibitors with good potency and pharmacokinetics (PK) has been designed by modification of an acidic startpoint. This was achieved by selecting the acid with the highest ligand lipophilicity efficiency (LLE) and replacing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b7b268fa1152bf9f3e80d035f31f2d5
https://doi.org/10.1039/c2md20231j
https://doi.org/10.1039/c2md20231j
Autor:
Simon M. Poucher, John Myatt, Joanne Teague, Laraine Gregory, Eike Floettmann, Clare D. Hammond, Huw B. Jones
Publikováno v:
Toxicologic Pathology. 38:393-401
The preclinical efficacy and safety of GPi921, a glycogen phosphorylase inhibitor, was assessed following twenty-eight days of administration to Zucker Diabetic Fatty (ZDF) rats. The ZDF rat is an animal model of type 2 diabetes mellitus (TTDM) which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1578f4707cf803e0a6ca618d0c5c22c6
https://doi.org/10.1177/0192623310362707
https://doi.org/10.1177/0192623310362707
Autor:
Judith A. Hargreaves, John G. Swales, Amin Rostami-Hodjegan, Linh M. Van, Claire Wilson, Clare D. Hammond
Publikováno v:
European Journal of Pharmaceutical Sciences. 31:53-61
Methylenedioxymethamphetamine (MDMA) was investigated in cryopreserved human hepatocytes as a time-dependent inactivator (TDI) of CYP2D6 using dextromethorphan (DEX) as a probe substrate. Inhibition kinetic parameters k(inact), the maximal rate of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eadeb0332ca79ece00ac4c00e74713d
https://doi.org/10.1016/j.ejps.2007.02.005
https://doi.org/10.1016/j.ejps.2007.02.005
Autor:
Raimund M. Peter, John G. Swales, Charles John O'donnell, Richard T. Gallagher, Gary Wilkinson, Clare D. Hammond
Publikováno v:
International Journal of High Throughput Screening.
John G Swales, Gary Wilkinson, Richard Gallagher, Clare Hammond, Charles O’Donnell, Raimund PeterAstraZeneca, Discovery Drug Metabolism and Pharmacokinetics, CVGI Research Area, Alderley Park, Macclesfield, Cheshire, UKAbstract: High performance li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c470a5bb65a2682cd37e3e845136400
https://www.dovepress.com/open-access-liquid-chromatographytandem-mass-spectrometry-implementati-peer-reviewed-article-IJHTS
https://www.dovepress.com/open-access-liquid-chromatographytandem-mass-spectrometry-implementati-peer-reviewed-article-IJHTS
Publikováno v:
MedChemComm; 2013, Vol. 4 Issue 1, p3-16, 14p
Autor:
Goldberg, Frederick W., Birch, Alan M., Leach, Andrew G., Groombridge, Sam D., Snelson, Wendy L., Gutierrez, Pablo Morentin, Hammond, Clare D., Birtles, Susan, Buckett, Linda K.
Publikováno v:
MedChemComm; 2013, Vol. 4 Issue 1, p165-174, 10p