Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Clare C, Davies"'
Autor:
Maria Pilar Sanchez-Bailon, Soo-Youn Choi, Elizabeth R. Dufficy, Karan Sharma, Gavin S. McNee, Emma Gunnell, Kelly Chiang, Debashish Sahay, Sarah Maslen, Grant S. Stewart, J. Mark Skehel, Ingrid Dreveny, Clare C. Davies
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Post-translational modifications are critical for regulating the DNA damage response. Here, the authors identify a methylation-deubiquitination crosstalk between methyltransferase PRMT1 and deubiquitinase USP11, showing that the enzymes regulate each
Externí odkaz:
https://doaj.org/article/ea281da007d54673887d7d80ba9fed3c
Autor:
Oliver Hartmann, Michaela Reissland, Carina R. Maier, Thomas Fischer, Cristian Prieto-Garcia, Apoorva Baluapuri, Jessica Schwarz, Werner Schmitz, Martin Garrido-Rodriguez, Nikolett Pahor, Clare C. Davies, Florian Bassermann, Amir Orian, Elmar Wolf, Almut Schulze, Marco A. Calzado, Mathias T. Rosenfeldt, Markus E. Diefenbacher
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Lung cancer is the most common cancer worldwide and the leading cause of cancer-related deaths in both men and women. Despite the development of novel therapeutic interventions, the 5-year survival rate for non-small cell lung cancer (NSCLC) patients
Externí odkaz:
https://doaj.org/article/25bb6c9a9e3b4539a37791d85b52657e
Autor:
Kelly Chiang, Agnieszka E. Zielinska, Abeer M. Shaaban, Maria Pilar Sanchez-Bailon, James Jarrold, Thomas L. Clarke, Jingxian Zhang, Adele Francis, Louise J. Jones, Sally Smith, Olena Barbash, Ernesto Guccione, Gillian Farnie, Matthew J. Smalley, Clare C. Davies
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3498-3513 (2017)
Summary: Breast cancer progression, treatment resistance, and relapse are thought to originate from a small population of tumor cells, breast cancer stem cells (BCSCs). Identification of factors critical for BCSC function is therefore vital for the d
Externí odkaz:
https://doaj.org/article/c87094c1b9fa49f294c1e88bb72d1739
Autor:
Kelly Chiang, Clare C. Davies
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
The arginine methyltransferase PRMT5 has been increasingly associated with cancer development. Here we describe our recent findings that PRMT5 is a critical regulator of breast cancer stem cell survival via the epigenetic regulation of FOXP1. Consequ
Externí odkaz:
https://doaj.org/article/5f98c23acbb04ba4831b4c335aeceb40
Publikováno v:
Cancers. 15:1897
First-line cancer treatments successfully eradicate the differentiated tumour mass but are comparatively ineffective against cancer stem cells (CSCs), a self-renewing subpopulation thought to be responsible for tumour initiation, metastasis, heteroge
Publikováno v:
'Biochemical Journal ', vol: 477, pages: 787-800 (2020)
Biochemical Journal
Biochemical Journal
Attenuating the function of protein arginine methyltransferases (PRMTs) is an objective for the investigation and treatment of several diseases including cardiovascular disease and cancer. Bisubstrate inhibitors that simultaneously target binding sit
Autor:
Elizabeth R. Dufficy, Karan Sharma, Maria Pilar Sanchez-Bailon, Grant S. Stewart, Kelly Chiang, Sarah L. Maslen, Soo-Youn Choi, Emma A. Gunnell, Clare C. Davies, Debashish Sahay, Ingrid Dreveny, Gavin S. McNee, J. Mark Skehel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Cross-talk between distinct protein post-translational modifications is critical for an effective DNA damage response. Arginine methylation plays an important role in maintaining genome stability, but how this modification integrates with other enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be0c226075a1ed2bb9cfe81e979b0a9
https://nottingham-repository.worktribe.com/file/6681867/1/S41467-021-26413-6
https://nottingham-repository.worktribe.com/file/6681867/1/S41467-021-26413-6
Autor:
Oliver, Hartmann, Michaela, Reissland, Carina R, Maier, Thomas, Fischer, Cristian, Prieto-Garcia, Apoorva, Baluapuri, Jessica, Schwarz, Werner, Schmitz, Martin, Garrido-Rodriguez, Nikolett, Pahor, Clare C, Davies, Florian, Bassermann, Amir, Orian, Elmar, Wolf, Almut, Schulze, Marco A, Calzado, Mathias T, Rosenfeldt, Markus E, Diefenbacher
Publikováno v:
Frontiers in Cell and Developmental Biology
Lung cancer is the most common cancer worldwide and the leading cause of cancer-related deaths in both men and women. Despite the development of novel therapeutic interventions, the 5-year survival rate for non-small cell lung cancer (NSCLC) patients
Autor:
Clare C. Davies, James Jarrold
Publikováno v:
Trends in molecular medicine. 25(11)
Post-translational modification (PTM) of proteins is vital for increasing proteome diversity and maintaining cellular homeostasis. If the writing, reading, and removal of modifications are not controlled, cancer can develop. Arginine methylation is a
Autor:
Kelly Chiang, Agnieszka E. Zielinska, Abeer M. Shaaban, Maria Pilar Sanchez-Bailon, James Jarrold, Thomas L. Clarke, Jingxian Zhang, Adele Francis, Louise J. Jones, Sally Smith, Olena Barbash, Ernesto Guccione, Gillian Farnie, Matthew J. Smalley, Clare C. Davies
Publikováno v:
Cell Reports
Cell Reports, Vol 21, Iss 12, Pp 3498-3513 (2017)
Cell Reports, Vol 21, Iss 12, Pp 3498-3513 (2017)
Summary Breast cancer progression, treatment resistance, and relapse are thought to originate from a small population of tumor cells, breast cancer stem cells (BCSCs). Identification of factors critical for BCSC function is therefore vital for the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::00806a6998cff3fa8612eb0980054ebf
https://ora.ox.ac.uk/objects/uuid:c8dac21c-ded6-4d62-9b35-2dc22ab73d57
https://ora.ox.ac.uk/objects/uuid:c8dac21c-ded6-4d62-9b35-2dc22ab73d57