Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Clare Bergson"'
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211903 (2019)
The link between blood pressure (BP) and cerebral function is well established. However, it is not clear whether a common mechanism could underlie the relationship between elevated BP and cognitive deficits. The expression of calcyon, a gene abundant
Externí odkaz:
https://doaj.org/article/3ccec63bcc074812ab73bfacda0dfdb2
Autor:
Liang Shi, Clare Bergson
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 10, Iss 1, Pp 1-11 (2020)
Translational Psychiatry, Vol 10, Iss 1, Pp 1-11 (2020)
Neurodevelopmental psychiatric disorders including schizophrenia (Sz) and attention deficit hyperactivity disorder (ADHD) are chronic mental illnesses, which place costly and painful burdens on patients, their families and society. In recent years, t
Autor:
Kehong Ding, Mark W. Hamrick, Jianrui Xu, Mohammed Elsalanty, Xingming Shi, Trevor Hardigan, Patricia Lopez, Maria C. Isales, Wendy B. Bollag, Meghan E. McGee-Lawrence, Crystal Perkins, Monte Hunter, Michael Cain, William D. Hill, Carlos M. Isales, Qing Zhong, Michael J. Davis, Clare Bergson
Publikováno v:
Bone. 115:15-24
Except for the essential amino acids (AAs), much of the focus on adequate dietary protein intake has been on total nitrogen and caloric intake rather than AA composition. Recent data, however, demonstrate that “amino-acid sensing” can occur throu
Publikováno v:
Molecular Biology of the Cell
Transport of late endosomes and lysosome-related organelles (LE/LROs) in axons is essential for supplying synaptic cargoes and for removing damaged macromolecules. Defects in this system are implicated in a range of human neurodegenerative and neurod
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 90:93-102
The neuron-enriched, endosomal protein Calcyon (Caly) regulates endocytosis and vesicle sorting, and is important for synaptic plasticity and brain development. In the current investigation of Caly interacting proteins in brain, the microtubule retro
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 2, p e0211903 (2019)
PLoS ONE, Vol 14, Iss 2, p e0211903 (2019)
The link between blood pressure (BP) and cerebral function is well established. However, it is not clear whether a common mechanism could underlie the relationship between elevated BP and cognitive deficits. The expression of calcyon, a gene abundant
Publikováno v:
Journal of Neurochemistry. 132:20-31
Understanding mechanisms governing the trafficking of transmembrane (TM) cargoes to synapses and other specialized membranes in neurons represents a long-standing challenge in cell biology. Investigation of the neuron-enriched endosomal protein of 21
Publikováno v:
Journal of Neurochemistry. 123:60-72
Calcyon is a neural enriched, single transmembrane protein that interacts with clathrin light chain and stimulates clathrin assembly and clathrin-mediated endocytosis. A similar property is shared by the heterotetrameric adaptor protein (AP) complexe
Publikováno v:
Molecular Psychiatry. 16:672-684
Calcyon regulates activity-dependent internalization of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) glutamate receptors and long-term depression of excitatory synapses. Elevated levels of calcyon are consistently observed in brains fro
Publikováno v:
Neuroscience Letters. 440:59-62
Recent observations suggest that calcyon, a novel single transmembrane protein implicated in schizophrenia and attention-deficit/hyperactivity disorder, regulates clathrin-mediated endocytosis in brain. To explore the role of calcyon in neurotransmis