Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Clare A. Parker"'
Autor:
Marcus Eng Hock Ong, Sean Shao Wei Lam, Stella Xinzi Wu, Clare Allison Parker, Yuzeng Shen, Nan Liu
Publikováno v:
The American Journal of Emergency Medicine. 37:1498-1504
Background Emergency department (ED) overcrowding is a growing international patient safety issue. A major contributor to overcrowding is long wait times for inpatient hospital admission. The objective of this study is to create a model that can pred
Autor:
Suresh K. Mendu, Marta E. Stremska, Bimal N. Desai, Julia K. Krupa, Clare A. Parker, Michael S. Schappe, Eric J. Stipes, Jason S. Rogers, Justin S. A. Perry, Emily K. Moser, Thomas J. Braciale
Publikováno v:
Sci Signal
The thymic development of regulatory T (T(reg)) cells, crucial suppressors of the responses of effector T (T(eff)) cells, is governed by the transcription factor FOXP3. Despite the clinical importance of T(reg) cells, there is a dearth of druggable m
Autor:
Mark A. Mitchell, Terry M. Norton, Clare E. Parker, Kelly E. Rockwell, Jennifer E. Flower, Kimberly M. Andrews, L. Michael Romero
Publikováno v:
Journal of Zoo and Wildlife Medicine. 49:9-17
Characterizing the health status and reproductive success of wild populations of sea turtles can be difficult; however, obtaining data to do this can provide important insight into the stability and long-term success of a population. This study exami
Autor:
Clare E. Parker, Ari Waisman, Lindsay H. Laws, Yoshinobu Koguchi, Martin H. Oberbarnscheidt, Mark K. Slifka, Leonardo V. Riella, Jagdeep S. Obhrai, Melissa Y. Yeung, Ganesh Cherala
Publikováno v:
American Journal of Transplantation. 16:3139-3149
B cells play a central role in antibody-mediated rejection and certain autoimmune diseases. However, B cell-targeted therapy such as anti-CD20 B cell-depleting antibody (aCD20) has yielded mixed results in improving outcomes. In this study, we invest
Autor:
Michael S. Schappe, Suresh K. Mendu, Julia K. Krupa, Eric J. Stipes, Emily K. Moser, Jason S. Rogers, Clare A. Parker, Bimal N. Desai, Thomas J. Braciale
In BriefGenetic deletion of Trpm7 in T-cells or pharmacological inhibition of TRPM7 channel promotes the development of fully functional Treg cells by increasing IL-2Rα and STAT5-dependent FOXP3 expression in the developing thymocytes. The study ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea3e524fb619577d530826fb3e9a7ea
https://doi.org/10.1101/330233
https://doi.org/10.1101/330233
Publikováno v:
Kidney and Blood Pressure Research. 33:313-330
In this study, we compared the activity of interleukin-6 (IL-6), a marker of ongoing peritoneal inflammation and biocompatibility, and its other signaling components, the soluble IL-6 receptor (sIL-6R) and soluble Gp130 (sGp130), in peritoneal efflue
Publikováno v:
Behavioral Ecology, vol 26, iss 3
Author(s): Grunst, ML; Grunst, AS; Parker, CE; Romero, LM; Rotenberry, JT | Abstract: The adrenocortical stress response may divert energy away from sexual ornamentation, such that ornaments signal exposure or resistance to physiological stress. Alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705d0b673ac723b30fa5e9def07865af
https://escholarship.org/uc/item/7193k50s
https://escholarship.org/uc/item/7193k50s
Publikováno v:
Scopus-Elsevier
Background: Post-traumatic MOF results from local tissue injury because of migration and activation of dysfunctional polymorphonuclear leukocytes (PMN). Although fracture surgery exacerbates the postinjury inflammatory response, it is usually benefic
Autor:
Nicholas Topley, Brendan J. Jenkins, Rachel M. McLoughlin, Ceri Alan Fielding, Matthias Ernst, Anwen Sian Williams, Clare R. Parker, Dianne Grail, Simon Arnett Jones
Publikováno v:
Proceedings of the National Academy of Sciences. 102:9589-9594
Interleukin (IL)-6 signaling through its soluble receptor (IL-6 transsignaling) directs transition between innate and acquired immune responses by orchestrating the chemokine-directed attraction and apoptotic clearance of leukocytes. Through analysis
Autor:
Clare R. Parker, Simon Arnett Jones, Nicholas Topley, Stefan Rose-John, Rachel M. McLoughlin, Jürgen Scheller, Raj Malhotra, Anwen Sian Williams, John D. Williams, Gareth W. Jones, Victoria Jayne Hammond
Publikováno v:
University of Bristol-PURE
IL-6 responses are classically orchestrated via a membrane-bound IL-6R (CD126) α subunit (classical IL-6R signaling) or through a soluble form of this cognate receptor (IL-6 trans signaling). Appraisal of IL-6R expression on human and mouse T cells