Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Clare, Keddy"'
Autor:
Kristen Jones, Clare Keddy, Chelsea Jenkins, Katelyn Nicholson, Ujwal Shinde, Monika A. Davare
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The ROS1 receptor tyrosine kinase (RTK) possesses the largest extracellular amino-terminal domain (ECD) among the human RTK family, yet the mechanisms regulating its activation are not fully understood. While chimeric ROS1 fusion proteins, r
Externí odkaz:
https://doaj.org/article/66839e6de01149af9218b507876cdf74
Autor:
Rajat Thawani, Matteo Repetto, Clare Keddy, Katelyn Nicholson, Kristen Jones, Kevin Nusser, Catherine Z. Beach, Guilherme Harada, Alexander Drilon, Monika A. Davare
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract ROS1 tyrosine kinase inhibitors (TKIs) are highly effective in ROS1-positive non-small cell lung cancer, but resistance remains a challenge. We investigated the activity of various TKIs against wildtype and mutant ROS1, focusing on the emerg
Externí odkaz:
https://doaj.org/article/a2f0d426aed049d5ae3fab63257a9869
Autor:
Rajat Thawani, Matteo Repetto, Clare Keddy, Katelyn Nicholson, Kristen Jones, Kevin Nusser, Catherine Z. Beach, Guilherme Harada, Alexander Drilon, Monika A. Davare
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/31196ad66dfb436eb7493219d57ee85d
Autor:
Sudarshan R Iyer, Kevin Nusser, Kristen Jones, Pushkar Shinde, Clare Keddy, Catherine Z Beach, Erin Aguero, Jeremy Force, Ujwal Shinde, Monika A Davare
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 10, Pp n/a-n/a (2023)
Abstract ROS1 is the largest receptor tyrosine kinase in the human genome. Rearrangements of the ROS1 gene result in oncogenic ROS1 kinase fusion proteins that are currently the only validated biomarkers for targeted therapy with ROS1 TKIs in patient
Externí odkaz:
https://doaj.org/article/808793d75f2f413c9604e051833dd047
Autor:
Jessica J. Lin, Henry E. Pelish, Aaron N. Hata, Monika A. Davare, Viola Zhu, Matthew D. Shair, James R. Porter, Nancy E. Kohl, John R. Soglia, Yuting Sun, Scot Mente, Satoshi Yoda, Katelyn S. Nicholson, Clare Keddy, Adam Acker, Linh Nguyen-Phuong, Anthonie J. van der Wekken, D. Ross Camidge, Shirish M. Gadgeel, Sai-Hong Ignatius Ou, Benjamin Besse, Anupong Tangpeerachaikul, Joshua C. Horan, Alexander Drilon
NVL-520 Modeling, Properties, Biochemical Activity, Cellular Activity, and In Vivo Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179b478fa795d20f06c52f43443d2a80
https://doi.org/10.1158/2159-8290.22542255
https://doi.org/10.1158/2159-8290.22542255
Autor:
Jessica J. Lin, Henry E. Pelish, Aaron N. Hata, Monika A. Davare, Viola Zhu, Matthew D. Shair, James R. Porter, Nancy E. Kohl, John R. Soglia, Yuting Sun, Scot Mente, Satoshi Yoda, Katelyn S. Nicholson, Clare Keddy, Adam Acker, Linh Nguyen-Phuong, Anthonie J. van der Wekken, D. Ross Camidge, Shirish M. Gadgeel, Sai-Hong Ignatius Ou, Benjamin Besse, Anupong Tangpeerachaikul, Joshua C. Horan, Alexander Drilon
ROS1 tyrosine kinase inhibitors (TKI) have been approved (crizotinib and entrectinib) or explored (lorlatinib, taletrectinib, and repotrectinib) for the treatment of ROS1 fusion–positive cancers, although none of them simultaneously address the nee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fc95b4f0ef39c29165338ddd307aa5
https://doi.org/10.1158/2159-8290.c.6549846
https://doi.org/10.1158/2159-8290.c.6549846
Autor:
Monika A. Davare, Ujwal Shinde, Romel Somwar, Stefanie Kaech, Kristen Jones, Pushkar Shinde, Clare Keddy
Supplementary Movie 1Z-stack Animation of live confocal imaging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968144a79ae34ef6b0c34a7d7d30f1bf
https://doi.org/10.1158/1535-7163.22522848.v1
https://doi.org/10.1158/1535-7163.22522848.v1
Autor:
Monika A. Davare, Ujwal Shinde, Romel Somwar, Stefanie Kaech, Kristen Jones, Pushkar Shinde, Clare Keddy
Supplementary Movie 6Time-lapse movie of live confocal imaging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9e93cb89939e2a72cf6e213d12c11f
https://doi.org/10.1158/1535-7163.22522830.v1
https://doi.org/10.1158/1535-7163.22522830.v1
Autor:
Monika A. Davare, Ujwal Shinde, Romel Somwar, Stefanie Kaech, Kristen Jones, Pushkar Shinde, Clare Keddy
Supplementary DataRaw data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9b3a89d89d084ad521ce54a0db0e28
https://doi.org/10.1158/1535-7163.22522851.v1
https://doi.org/10.1158/1535-7163.22522851.v1
Autor:
Monika A. Davare, Ujwal Shinde, Romel Somwar, Stefanie Kaech, Kristen Jones, Pushkar Shinde, Clare Keddy
Supplementary Movie 7Z-stack Animation of live confocal imaging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db28fe0493acc4d12fd21e311b456a7
https://doi.org/10.1158/1535-7163.22522827
https://doi.org/10.1158/1535-7163.22522827