Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Clare, Bryant"'
Autor:
Zhenguang Zhang, Iain R. L. Kean, Lisa M. Dratva, John A. Clark, Eleni Syrimi, Naeem Khan, Esther Daubney, Deborah White, Lauran O’Neill, Catherine Chisholm, Caroline Payne, Sarah Benkenstein, Klaudia Kupiec, Rachel Galassini, Victoria Wright, Helen Winmill, Ceri Robbins, Katherine Brown, Padmanabhan Ramnarayan, Barnaby Scholefield, Mark Peters, Nigel Klein, Hugh Montgomery, Kerstin B. Meyer, Sarah A. Teichmann, Clare Bryant, Graham Taylor, Nazima Pathan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Multisystem inflammatory syndrome in children is a post-infectious presentation SARS-CoV-2 associated with expansion of the T cell receptor Vβ21.3+ T-cell subgroup. Here we apply muti-single cell omics to compare the inflammatory process in
Externí odkaz:
https://doaj.org/article/24631b7ed7a34550a699c037c3f5c247
Autor:
Marta Baldrighi, Christian Doreth, Yang Li, Xiaohui Zhao, Emily Warner, Hannah Chenoweth, Kamal Kishore, Yagnesh Umrania, David-Paul Minde, Sarah Thome, Xian Yu, Yuning Lu, Alice Knapton, James Harrison, Murray Clarke, Eicke Latz, Guillermo de Cárcer, Marcos Malumbres, Bernhard Ryffel, Clare Bryant, Jinping Liu, Kathryn S. Lilley, Ziad Mallat, Xuan Li
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Unabated activation of the NLR family pyrin domain–containing 3 (NLRP3) inflammasome is linked with the pathogenesis of various inflammatory disorders. Polo-like kinase 1 (PLK1) has been widely studied for its role in mitosis. Here, using both phar
Externí odkaz:
https://doaj.org/article/9ec59b6ac22e465f89c2f85931f35cac
Autor:
Suman De, Daniel R. Whiten, Francesco S. Ruggeri, Craig Hughes, Margarida Rodrigues, Dimitrios I. Sideris, Christopher G. Taylor, Francesco A. Aprile, Serge Muyldermans, Tuomas P. J. Knowles, Michele Vendruscolo, Clare Bryant, Kaj Blennow, Ingmar Skoog, Silke Kern, Henrik Zetterberg, David Klenerman
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Soluble aggregates of amyloid-β (Aβ) have been associated with neuronal and synaptic loss in Alzheimer’s disease (AD). However, despite significant recent progress, the mechanisms by which these aggregated species contribute to disease p
Externí odkaz:
https://doaj.org/article/78c3bbe6945d419e8ab9472bc42c0fcb
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
Autor:
Suman De, David C. Wirthensohn, Patrick Flagmeier, Craig Hughes, Francesco A. Aprile, Francesco S. Ruggeri, Daniel R. Whiten, Derya Emin, Zengjie Xia, Juan A. Varela, Pietro Sormanni, Franziska Kundel, Tuomas P. J. Knowles, Christopher M. Dobson, Clare Bryant, Michele Vendruscolo, David Klenerman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Amyloid beta (Aβ42) peptides form heterogeneous mixtures of aggregates, which are closely linked to Alzheimer’s disease. This study shows how different types of Aβ42 aggregates are associated with distinct mechanisms of toxicity
Externí odkaz:
https://doaj.org/article/dda94a3ed6064b0ba41892597f9160ae
Autor:
Caroline Smith, Cedar Fowler, Un-In Wu, Robyn Shaffer, Lisa Barnhart, Clare Bryant, Kenneth Olivier, Steven M Holland
Publikováno v:
BMJ Open Respiratory Research, Vol 7, Iss 1 (2020)
RationalePulmonary non-tuberculous mycobacterial (PNTM) disease has increased over the past several decades, especially in older women. Abnormal mucociliary clearance and abnormal nasal nitric oxide (nNO) have been associated with PNTM disease in oth
Externí odkaz:
https://doaj.org/article/845651adf472454e8320d9ca96ae82c1
Autor:
Tom P. Monie, Clare Bryant
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Pattern Recognition Receptors (PRRs, [110]) (nomenclature as agreed by NC-IUPHAR sub-committee on Pattern Recognition Receptors, [20]) participate in the innate immune response to microbial agents, the stimulation of which leads to activation of intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dc82b0131153b61c91a33937e63119f
https://doi.org/10.2218/gtopdb/f302/2023.1
https://doi.org/10.2218/gtopdb/f302/2023.1
Autor:
Clare Bryant, Joseph Boyle
Publikováno v:
Encyclopedia of Cell Biology ISBN: 9780128216248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70d0b54d265f57334fe661c85445d874
https://doi.org/10.1016/b978-0-12-821618-7.00204-2
https://doi.org/10.1016/b978-0-12-821618-7.00204-2
Autor:
Steve J Webster, Sven Brode, Lou Ellis, Timothy J Fitzmaurice, Matthew J Elder, Nelson O Gekara, Panagiotis Tourlomousis, Clare Bryant, Simon Clare, Ronnie Chee, Hill J S Gaston, Jane C Goodall
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006383 (2017)
The innate immune system is a critical component of host defence against microbial pathogens, but effective responses require an ability to distinguish between infectious and non-infectious insult to prevent inappropriate inflammation. Using the impo
Externí odkaz:
https://doaj.org/article/cc7ab21c35704bf99075bec68f1688a5
Autor:
Linda Julian, Jason C. Sang, Yunzhao Wu, Georg Meisl, Jack H. Brelstaff, Alyssa Miller, Matthew R. Cheetham, Michele Vendruscolo, Tuomas P.J. Knowles, Francesco Simone Ruggeri, Clare Bryant, Susana Ros, Kevin M. Brindle, David Klenerman
Publikováno v:
Biophysical journal. 121(22)
Mutations in the TP53 gene are common in cancer with the R248Q missense mutation conferring an increased propensity to aggregate. Previous p53 aggregation studies showed that, at micromolar concentrations, protein unfolding to produce aggregation-pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b905583b8be594ce2275211226a84d29
https://pubmed.ncbi.nlm.nih.gov/36230002
https://pubmed.ncbi.nlm.nih.gov/36230002