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Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Autor: Kato N; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Comer E; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Sakata-Kato T; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA., Sharma A; Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India., Sharma M; Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India., Maetani M; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA., Bastien J; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Brancucci NM; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA., Bittker JA; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Corey V; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, California 92093, USA., Clarke D; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA., Derbyshire ER; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.; Department of Chemistry and Department of Molecular Genetics and Microbiology, Duke University, 124 Science Drive, Durham, North Carolina 27708, USA., Dornan GL; Department of Biochemistry and Microbiology, University of Victoria, 270 Petch Hall, Victoria, British Colombia V8P 5C2, Canada., Duffy S; Eskitis Institute for Drug Discovery, Griffith University, Nathan Campus, Griffith University, Nathan, Brisbane, Queensland 4111, Australia., Eckley S; Eisai Inc., 4 Corporate Drive, Andover, Massachusetts 01810, USA., Itoe MA; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA., Koolen KM; TropIQ Health Sciences, Geert Grooteplein 28, Huispost 268, 6525 GA Nijmegen, The Netherlands., Lewis TA; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Lui PS; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA., Lukens AK; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA., Lund E; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA., March S; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02142, USA., Meibalan E; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA., Meier BC; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA., McPhail JA; Department of Biochemistry and Microbiology, University of Victoria, 270 Petch Hall, Victoria, British Colombia V8P 5C2, Canada., Mitasev B; Eisai Inc., 4 Corporate Drive, Andover, Massachusetts 01810, USA., Moss EL; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Sayes M; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Van Gessel Y; Eisai Inc., 4 Corporate Drive, Andover, Massachusetts 01810, USA., Wawer MJ; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Yoshinaga T; Eisai Co. Ltd, 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan., Zeeman AM; Department of Parasitology, Biochemical Primate Research Centre, 2280 GH Rijswijk, The Netherlands., Avery VM; Eskitis Institute for Drug Discovery, Griffith University, Nathan Campus, Griffith University, Nathan, Brisbane, Queensland 4111, Australia., Bhatia SN; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02142, USA., Burke JE; Department of Biochemistry and Microbiology, University of Victoria, 270 Petch Hall, Victoria, British Colombia V8P 5C2, Canada., Catteruccia F; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA., Clardy JC; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA., Clemons PA; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Dechering KJ; TropIQ Health Sciences, Geert Grooteplein 28, Huispost 268, 6525 GA Nijmegen, The Netherlands., Duvall JR; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Foley MA; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Gusovsky F; Eisai Inc., 4 Corporate Drive, Andover, Massachusetts 01810, USA., Kocken CH; Department of Parasitology, Biochemical Primate Research Centre, 2280 GH Rijswijk, The Netherlands., Marti M; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA., Morningstar ML; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Munoz B; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Neafsey DE; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Sharma A; Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India., Winzeler EA; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, California 92093, USA., Wirth DF; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA., Scherer CA; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA., Schreiber SL; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

Publikováno v: Nature [Nature] 2016 Oct 20; Vol. 538 (7625), pp. 344-349. Date of Electronic Publication: 2016 Sep 07.

Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists.

Autor: Jiang J; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0810, USA., Li AH, Jang SY, Chang L, Melman N, Moro S, Ji X, Lobkovsky EB, Clardy JC, Jacobson KA

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1999 Aug 12; Vol. 42 (16), pp. 3055-65.

Pentacyclo[12.2.2.22,5.26,9.210,13]-1,5,9,13-tetracosatetraene and its reaction with silver trifluoromethanesulfonate. Synthesis of a square-planar d10 organometallic complex.

Autor: McMurry JE, Haley GJ, Matz JR, Clardy JC, Mitchell J

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 1986 Feb 01; Vol. 108 (3), pp. 515-6.