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Autor:
J. O. Hui, Jackson B. Hester, Mariusz Jaskolski, Alexander Wlodawer, Jessica Harris, Ben M. Dunn, Heinrich J. Schostarez, A G Tomasselli, Roger A. Poorman, Charles S. Craik, L. Liu, D J Staples, D. L. Decamp, Tomi K. Sawyer, W. Todd Lowther, Robert L. Heinrikson, Kathy O'connell, W. Jeffrey Howe, Joseph B. Moon, Clarck W. Smith
Publikováno v:
International journal of peptide and protein research. 40(3-4)
This report details the structure-activity relationships of the HIV gag substrate analog Val-Ser-Gln-Asn-Leu psi[CH(OH)CH2]Val-Ile-Val (U-85548E), an inhibitor exhibiting subnanomolar affinity towards HIV type-1 aspartic proteinase (HIV-1 PR). Our da