Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Clara Zaccaro"'
Autor:
Karen D. Nylander, Carmel F. Portugal, Chaohua Yan, Marcelo Rudzinski, Ye Liang, H. Uri Saragovi, Zeljka Korade Mirnics, Nina F. Schor, Clara Zaccaro
Publikováno v:
Molecular Brain Research. 139:225-234
Neocarzinostatin (NCS), an enediyne antimitotic agent, induces cell death in both p75NTR neurotrophin receptor (NTR)-positive and p75NTR-negative PC12 cells in a concentration-dependent fashion. However, p75NTR-positive cells demonstrate a higher sus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2afbec46ff0191eba69aa92dc5e8b099
https://doi.org/10.1016/j.molbrainres.2005.05.025
https://doi.org/10.1016/j.molbrainres.2005.05.025
Autor:
Maria Clara Zaccaro, Hong Boon Lee, Sudipta Roy, Mookda Pattarawarapan, H. Uri Saragovi, Kevin Burgess
Publikováno v:
The Journal of Organic Chemistry. 69:701-713
A program to identify small molecules that mimic or disrupt protein-protein interactions led us to design the peptidomimetics 1-3. Solid-phase syntheses of 1-3 were developed. The purities of the crude materials isolated from the resin tend to be hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b23d0595ecdd8156e6b9adc25ca4b7
https://doi.org/10.1021/jo034167x
https://doi.org/10.1021/jo034167x
Autor:
Zebin Xia, Maria Clara Zaccaro, Samuel Reyes, Mookda Pattarawarapan, H. Uri Saragovi, Kevin Burgess
Publikováno v:
Journal of Medicinal Chemistry. 46:3565-3567
Methodology is presented for assembling fluorescently labeled bivalent molecules from monovalent constituents, without side chain protection or coupling agents. To illustrate the procedure, a series of bivalent peptidomimetics directed toward the Trk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405d239740165027f105eaf2f6e95d99
https://doi.org/10.1021/jm034103e
https://doi.org/10.1021/jm034103e
Autor:
H. Uri Saragovi, Yulia Y. Tyurina, Karen D. Nylander, Chaohua Yan, Carmel F. Portugal, Clara Zaccaro, Valerian E. Kagan, Zeljka Korade Mirnics, Nina F. Schor
Publikováno v:
Aging cell. 4(4)
Summary The low-affinity neurotrophin receptor, p75NTR, has been found to be pro- or anti-apoptotic depending upon the cell in which it is expressed. Reactive oxygen species play a major role in apoptosis induction and enactment. Using two polyclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5f1630cff386b046595f33a32ff6d8
https://pubmed.ncbi.nlm.nih.gov/16026333
https://pubmed.ncbi.nlm.nih.gov/16026333
Autor:
Hong Boon Lee, Zebin Xia, Pierrre-Jean L’Heureux, Kevin Burgess, Mookda Pattarawarapan, Antoine Caron, Maria Clara Zaccaro, Yoshua Bengio, H. Uri Saragovi
Publikováno v:
Chemistrybiology. 12(9)
SummaryWe designed a minilibrary of 55 small molecule peptidomimetics based on β-turns of the neurotrophin growth factor polypeptides neurotrophin-3 (NT-3) and nerve growth factor (NGF). Direct binding, binding competition, and biological screens id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074a3ce31cc3003c307e85c42a4a598e
https://pubmed.ncbi.nlm.nih.gov/16183026
https://pubmed.ncbi.nlm.nih.gov/16183026
Publikováno v:
Journal of medicinal chemistry. 45(20)
beta-Turn peptidomimetics 1 were designed to mimic hot spots of neurotrophin-3 (NT-3) and others. Solid-phase syntheses of these were developed, though limitations were encountered with scale-up. Consequently, an alternative design with 2 was investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bcf10462a7856c6fd05528dc3b87a4f
https://pubmed.ncbi.nlm.nih.gov/12238916
https://pubmed.ncbi.nlm.nih.gov/12238916
Publikováno v:
The Journal of biological chemistry. 276(33)
Neurotrophins signal via Trk tyrosine kinase receptors and a common receptor called p75. Nerve growth factor is the cognate ligand for TrkA, brain-derived neurotrophic factor for TrkB, and neurotrophin-3 (NT-3) for TrkC. NT-3 also binds TrkA and TrkB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e938bf731f5c215d95018b7ccfe8e7
https://pubmed.ncbi.nlm.nih.gov/11425862
https://pubmed.ncbi.nlm.nih.gov/11425862
Autor:
Kalle Gehring, Irena Ekiel, Natalia Beglova, Maria Clara Zaccaro, Sergei Maliartchouk, H. Uri Saragovi
Publikováno v:
Journal of medicinal chemistry. 43(19)
The C-D loop in nerve growth factor (NGF) is involved in binding to the NGF receptor, TrkA. It is flexible and adopts several different types conformations in different NGF crystal forms. We have previously shown that a small cyclic peptide derived f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d80a93320d624c351e55796083abfee
https://pubmed.ncbi.nlm.nih.gov/11000007
https://pubmed.ncbi.nlm.nih.gov/11000007