Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Clara Torrellas"'
Autor:
Ramón Cacabelos, Clara Torrellas
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 12, Pp 30483-30543 (2015)
Epigenetic variability (DNA methylation/demethylation, histone modifications, microRNA regulation) is common in physiological and pathological conditions. Epigenetic alterations are present in different tissues along the aging process and in neurodeg
Externí odkaz:
https://doaj.org/article/52803c206ec347d8a92634fb273a4210
Publikováno v:
Mediators of Inflammation, Vol 2016 (2016)
Neuroimmune dysregulation is a common phenomenon in different forms of central nervous system (CNS) disorders. Cross-links between central and peripheral immune mechanisms appear to be disrupted as reflected by a series of immune markers (CD3, CD4, C
Externí odkaz:
https://doaj.org/article/fdfedf2442a645deb21a9c5f412e2b37
Publikováno v:
Current Genomics
Background: The response rate in the pharmacological treatment of depression has been estimated to be around 50%, achieving a remission in symptomatology in only one third of the patients. Suboptimal prescription of antidepressants has been proposed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff5089b8749aea027a9ca81399fc253
http://europepmc.org/articles/PMC5635649
http://europepmc.org/articles/PMC5635649
Publikováno v:
Pharmacogenomics. 17:1041-1074
The practical pharmacogenetics of Alzheimer's disease (AD) is circumscribed to acetylcholinesterase inhibitors (AChEIs) and memantine. However, pharmacogenetic procedures should be applied to novel strategies in AD therapeutics including: novel AChEI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fac265ad5ba929288e19c969d1bc20
https://doi.org/10.2217/pgs-2016-0031
https://doi.org/10.2217/pgs-2016-0031
Publikováno v:
Current Pharmaceutical Design. 22:819-848
The neuroimmune system represents a dense network of biochemical signals associated with neurotransmitters, neuropeptides, neurohormones, cytokines, chemokines, and growth factors synthesized in neurons, glial cells and immune cells, to maintain syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f515a97bf440c28d78c68868adbcdd
https://doi.org/10.2174/1381612822666151209150954
https://doi.org/10.2174/1381612822666151209150954
Autor:
Clara Torrellas, Ramón Cacabelos
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 12, Pp 30483-30543 (2015)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Epigenetic variability (DNA methylation/demethylation, histone modifications, microRNA regulation) is common in physiological and pathological conditions. Epigenetic alterations are present in different tissues along the aging process and in neurodeg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3671467f8fdcd1278bf1ed0d65122c9e
https://doi.org/10.3390/ijms161226236
https://doi.org/10.3390/ijms161226236
Publikováno v:
Future Neurology. 10:229-252
ABSTRACT In Alzheimer's disease (AD), approximately 10–20% of direct costs are associated with pharmacological treatment. Pharmacogenomics account for 30–90% variability in pharmacokinetics and pharmacodynamics. Genes potentially involved in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6774ab0fc44f0dfadfabc35c429e894b
https://doi.org/10.2217/fnl.15.12
https://doi.org/10.2217/fnl.15.12
Autor:
Clara Torrellas, Ramón Cacabelos
Publikováno v:
Expert Opinion on Drug Discovery. 9:1059-1086
It is assumed that epigenetic modifications are reversible and could potentially be targeted by pharmacological and dietary interventions. Epigenetic drugs are gaining particular interest as potential candidates for the treatment of Alzheimer's disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0980a80a35b6ea9ccf916682217dfb3
https://doi.org/10.1517/17460441.2014.930124
https://doi.org/10.1517/17460441.2014.930124
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Depósito Digital e-UCJC
Universidad Camilo José Cela (UCJC)
Mediators of Inflammation, Vol 2016 (2016)
Mediators of Inflammation
Consejería de Sanidad de la Comunidad de Madrid
Depósito Digital e-UCJC
Universidad Camilo José Cela (UCJC)
Mediators of Inflammation, Vol 2016 (2016)
Mediators of Inflammation
La desregulación neuroinmune es un fenómeno común en diferentes formas de trastornos del sistema nervioso central (SNC). Los enlaces cruzados entre los mecanismos inmunitarios centrales y periféricos parecen estar interrumpidos, como se refleja e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd4c2748cb4b3cbe74749911ce10031
http://hdl.handle.net/20.500.12020/842
http://hdl.handle.net/20.500.12020/842
Publikováno v:
Melatonin, Neuroprotective Agents and Antidepressant Therapy ISBN: 9788132228011
Antidepressants are among the most prescribed drugs in developed countries. Pharmacogenomics accounts for over 60 % variability in the pharmacodynamics and pharmacokinetics of antidepressants (selective serotonin reuptake inhibitors, serotonin–nore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7089bef7e754e8e969d6ecca82d33060
https://doi.org/10.1007/978-81-322-2803-5_35
https://doi.org/10.1007/978-81-322-2803-5_35