Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Clara Stead"'
Autor:
Cathleen Hsu, Robert M. Owen, Evan D. Morris, Gang Feng, Guido van Amerongen, Andy N. Mead, Sarah A. Nickolls, David S. Reynolds, Lishuang Cao, Juha Kammonen, Clara Stead, Ruolun Qiu, Donal Gorman, Richard P. Butt, Adam R. Brown, Joop M. A. van Gerven, Rachel Gurrell, Christine Anne Louise Watson, Mark Whitlock, Laigao Chen, Rebecca L. Fish, Andrew Pike, Pinky Dua
Publikováno v:
British Journal of Pharmacology. 175:708-725
Background and purpose Benzodiazepines, non-selective positive allosteric modulators (PAMs) of GABAA receptors, have significant side effects that limit their clinical utility. As many of these side effects are mediated by the α1 subunit, there has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da051882a6b4724d68b80dbf86c2760e
https://doi.org/10.1111/bph.14119
https://doi.org/10.1111/bph.14119
Autor:
Robert M, Owen, David, Blakemore, Lishuang, Cao, Neil, Flanagan, Rebecca, Fish, Karl R, Gibson, Rachel, Gurrell, Chan Woo, Huh, Juha, Kammonen, Elisabeth, Mortimer-Cassen, Sarah A, Nickolls, Kiyoyuki, Omoto, Dafydd, Owen, Andy, Pike, David C, Pryde, David S, Reynolds, Rosemarie, Roeloffs, Colin, Rose, Clara, Stead, Mifune, Takeuchi, Joseph S, Warmus, Christine, Watson
Publikováno v:
Journal of medicinal chemistry. 62(12)
The design, optimization, and evaluation of a series of novel imidazopyridazine-based subtype-selective positive allosteric modulators (PAMs) for the GABA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b852c98ab428508fb3c4d5969e61528
https://pubmed.ncbi.nlm.nih.gov/30964988
https://pubmed.ncbi.nlm.nih.gov/30964988
Autor:
Colin R. Rose, Elisabeth Mortimer-Cassen, Juha Kammonen, Rebecca L. Fish, David C. Pryde, Lishuang Cao, Sarah A. Nickolls, Neil J. Flanagan, Karl Richard Gibson, Joseph S. Warmus, Christine Anne Louise Watson, Chan Woo Huh, David J. Reynolds, Rachel Gurrell, Kiyoyuki Omoto, Andrew Pike, Clara Stead, David C. Blakemore, Rosemarie Roeloffs, Dafydd R. Owen, Mifune Takeuchi, Robert M. Owen
Publikováno v:
Journal of Medicinal Chemistry.
The design, optimization, and evaluation of a series of novel imidazopyridazine-based subtype-selective positive allosteric modulators (PAMs) for the GABAA ligand-gated ion channel are described. From a set of initial hits multiple subseries were des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69244f4f78fe59a3b806c142bdaa534b
https://doi.org/10.1021/acs.jmedchem.9b00322
https://doi.org/10.1021/acs.jmedchem.9b00322
Autor:
Gareth T. Young, Sarah J Nickolls, David C. Pryde, Cathryn Adams, Juha Kammonen, Clara Stead, Darren Cawkill, Adam R. Brown
Publikováno v:
Journal of biomolecular screening. 21(10)
Glycine receptor 3 (GlyRα3) is a ligand-gated ion channel of the cys-loop family that plays a key role in mediating inhibitory neurotransmission and regulation of pain signaling in the dorsal horn. Potentiation of GlyRα3 function is therefore of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c78532857654f04af9f4a8a1deeaf00
https://pubmed.ncbi.nlm.nih.gov/27412533
https://pubmed.ncbi.nlm.nih.gov/27412533