Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Clara Shionyu‐Mitsuyama"'
Autor:
Atsushi Hijikata, Clara Shionyu‐Mitsuyama, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Takatsugu Hirokawa, Shogo Nakajima, Koichi Watashi, Tsuyoshi Shirai
Publikováno v:
FEBS Open Bio, Vol 12, Iss 1, Pp 285-294 (2022)
Cepharanthine (CEP) is a natural biscoclaurine alkaloid of plant origin and was recently demonstrated to have anti‐severe acute respiratory syndrome coronavirus 2 (anti‐SARS‐CoV‐2) activity. In this study, we evaluated whether natural analogu
Externí odkaz:
https://doaj.org/article/107db267d382427094cc9f1a9c93c0be
Autor:
Motonori Ota, Clara Shionyu-Mitsuyama, Masafumi Shionyu, Shigehiko Kanaya, Atsushi Hijikata, Setsu Nakae, Tsuyoshi Shirai
Publikováno v:
FEBS Letters
Febs Letters
Febs Letters
The World Health Organization (WHO) has declared the coronavirus disease 2019 (COVID-19) caused by the novel coronavirus SARS-CoV-2 a pandemic. There is, however, no confirmed anti-COVID-19 therapeutic currently. In order to assist structure-based di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65067f9d4d1cc8448514d41692b7a2ac
https://doi.org/10.1002/1873-3468.13806
https://doi.org/10.1002/1873-3468.13806
Autor:
Clara Shionyu-Mitsuyama, Takatsugu Hirokawa, Atsushi Hijikata, Tsuyoshi Shirai, Setsu Nakae, Motonori Ota, Koichi Watashi, Masafumi Shionyu, Shogo Nakajima, Shigehiko Kanaya
Cepharanthine is a natural of plant origin, and recently demonstrated to have anti-SARS-CoV-2 activity. In order to evaluate the other natural analogues as a potential COVID-19 drug, a total of 24 compounds resembling cepharanthine were extracted fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::679d53955c1d089597586f3fd1ffb4fc
https://doi.org/10.33774/chemrxiv-2021-mcf3k
https://doi.org/10.33774/chemrxiv-2021-mcf3k
Publikováno v:
Journal of Structural and Functional Genomics. 17:135-146
The fast heuristic graph match algorithm for small molecules, COMPLIG, was improved by adding a structural superposition process to verify the atom-atom matching. The modified method was used to classify the small molecule ligands in the Protein Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81ed810b561c3e72ffd7b0152c60a16
https://doi.org/10.1007/s10969-016-9209-x
https://doi.org/10.1007/s10969-016-9209-x
Publikováno v:
Protein Engineering Design and Selection. 16:467-478
A computer program system was developed to predict carbohydrate-binding sites on three-dimensional (3D) protein structures. The programs search for binding sites by referring to the empirical rules derived from the known 3D structures of carbohydrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcf642b9a2f91138fe8124818d89326
https://doi.org/10.1093/protein/gzg065
https://doi.org/10.1093/protein/gzg065
Autor:
Takuma Shiraki, Kosuke Morikawa, Tsuyoshi Waku, Tsuyoshi Shirai, Clara Shionyu-Mitsuyama, Takuji Oyama
Publikováno v:
Protein engineering, designselection : PEDS. 24(4)
Nuclear receptors, intracellular lipid-binding proteins and metabolic enzymes are responsible for optimal metabolic homeostasis in higher organisms. Recent studies revealed the specific cooperation/competition among the subfamilies of these proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9fc175eab9039558a9a121f5c1b4db
https://pubmed.ncbi.nlm.nih.gov/21216727
https://pubmed.ncbi.nlm.nih.gov/21216727
Publikováno v:
Molecular diversity. 10(4)
The isoforms of a fish galectin, congerins I and II, have several features that make them suitable for a study of accelerated process of molecular diversification based on 3D structures: They have been generated by a gene duplication, and still maint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac62f13648fc80d8cb590c02659ebdb
https://pubmed.ncbi.nlm.nih.gov/16972013
https://pubmed.ncbi.nlm.nih.gov/16972013
Autor:
Tsuyoshi Shirai, Ayumu Konno, Koji Muramoto, Yoshimaro Ito, Tomohisa Ogawa, Clara Shionyu-Mitsuyama, Yukiko Miwa
Publikováno v:
Journal of molecular biology. 347(2)
The thermostability of the conger eel galectin, congerin II, was improved by in vitro evolutionary protein engineering. Two rounds of random PCR mutagenesis and selection experiments increased the congerin II thermostability to a level comparative to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321d85234b663c765d57cc4d8bfdda3c
https://pubmed.ncbi.nlm.nih.gov/15740748
https://pubmed.ncbi.nlm.nih.gov/15740748
Autor:
Hisao Kamiya, Clara Shionyu-Mitsuyama, Koji Muramoto, Tsuyoshi Shirai, Tomohisa Ogawa, Takashi Yamane
Publikováno v:
Glycoconjugate journal. 19(7-9)
Many cases of accelerated evolution driven by positive Darwinian selection are identified in the genes of venomous and reproductive proteins. This evolutional phenomenon might have important consequences in their gene-products' functions, such as mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e66967b8986ba0c8337efa620aad06c
https://pubmed.ncbi.nlm.nih.gov/14758068
https://pubmed.ncbi.nlm.nih.gov/14758068
Publikováno v:
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 48(14)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fa933a10d46caa9d855cb944fe0e24e
https://pubmed.ncbi.nlm.nih.gov/14619417
https://pubmed.ncbi.nlm.nih.gov/14619417