Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Clara Shionyu"'
Autor:
Atsushi Hijikata, Clara Shionyu‐Mitsuyama, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Takatsugu Hirokawa, Shogo Nakajima, Koichi Watashi, Tsuyoshi Shirai
Publikováno v:
FEBS Open Bio, Vol 12, Iss 1, Pp 285-294 (2022)
Cepharanthine (CEP) is a natural biscoclaurine alkaloid of plant origin and was recently demonstrated to have anti‐severe acute respiratory syndrome coronavirus 2 (anti‐SARS‐CoV‐2) activity. In this study, we evaluated whether natural analogu
Externí odkaz:
https://doaj.org/article/107db267d382427094cc9f1a9c93c0be
Current status of structure-based drug repurposing against COVID-19 by targeting SARS-CoV-2 proteins
Autor:
Atsushi Hijikata, Clara Shionyu, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Tsuyoshi Shirai
Publikováno v:
Biophysics and Physicobiology, Vol 18 (2021)
More than one and half years have passed, as of August 2021, since the COVID-19 caused by the novel coronavirus named SARS-CoV-2 emerged in 2019. While the recent success of vaccine developments likely reduces the severe cases, there is still a stron
Externí odkaz:
https://doaj.org/article/f3e93de53051417d91e2241d78485984
Autor:
Motonori Ota, Clara Shionyu-Mitsuyama, Masafumi Shionyu, Shigehiko Kanaya, Atsushi Hijikata, Setsu Nakae, Tsuyoshi Shirai
Publikováno v:
FEBS Letters
Febs Letters
Febs Letters
The World Health Organization (WHO) has declared the coronavirus disease 2019 (COVID-19) caused by the novel coronavirus SARS-CoV-2 a pandemic. There is, however, no confirmed anti-COVID-19 therapeutic currently. In order to assist structure-based di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65067f9d4d1cc8448514d41692b7a2ac
https://doi.org/10.1002/1873-3468.13806
https://doi.org/10.1002/1873-3468.13806
Autor:
Clara Shionyu-Mitsuyama, Takatsugu Hirokawa, Atsushi Hijikata, Tsuyoshi Shirai, Setsu Nakae, Motonori Ota, Koichi Watashi, Masafumi Shionyu, Shogo Nakajima, Shigehiko Kanaya
Cepharanthine is a natural of plant origin, and recently demonstrated to have anti-SARS-CoV-2 activity. In order to evaluate the other natural analogues as a potential COVID-19 drug, a total of 24 compounds resembling cepharanthine were extracted fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::679d53955c1d089597586f3fd1ffb4fc
https://doi.org/10.33774/chemrxiv-2021-mcf3k
https://doi.org/10.33774/chemrxiv-2021-mcf3k
Current status of structure-based drug repurposing against COVID-19 by targeting SARS-CoV-2 proteins
Autor:
Masafumi Shionyu, Shigehiko Kanaya, Clara Shionyu, Motonori Ota, Setsu Nakae, Atsushi Hijikata, Tsuyoshi Shirai
Publikováno v:
Biophysics and Physicobiology, Vol 18 (2021)
Biophysics and Physicobiology
Biophysics and Physicobiology
More than one and half years have passed, as of August 2021, since the COVID-19 caused by the novel coronavirus named SARS-CoV-2 emerged in 2019. While the recent success of vaccine developments likely reduces the severe cases, there is still a stron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c9c7aba9d79135cd0c7e3e37663651
https://doaj.org/article/f3e93de53051417d91e2241d78485984
https://doaj.org/article/f3e93de53051417d91e2241d78485984
Publikováno v:
Journal of Structural and Functional Genomics. 17:135-146
The fast heuristic graph match algorithm for small molecules, COMPLIG, was improved by adding a structural superposition process to verify the atom-atom matching. The modified method was used to classify the small molecule ligands in the Protein Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81ed810b561c3e72ffd7b0152c60a16
https://doi.org/10.1007/s10969-016-9209-x
https://doi.org/10.1007/s10969-016-9209-x
Autor:
Eishu Hirata, Shinji Kondo, Clara Shionyu, Honda Naoki, Hiroko Yukinaga, Kumiko Ui-Tei, Mariko Okada-Hatakeyama, Takeshi Nagashima, Michiyuki Matsuda
Publikováno v:
Journal of Cell Science. 127:1805-1815
Phenotypic heterogeneity of cancer cells is caused not only by genetic and epigenetic alterations but also by stochastic variation of intracellular signaling molecules. Using cells that stably express Förster resonance energy transfer (FRET) biosens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4b0ab136730fd7e814cd119593f4f6
https://doi.org/10.1242/jcs.139733
https://doi.org/10.1242/jcs.139733
Publikováno v:
Protein Engineering Design and Selection. 16:467-478
A computer program system was developed to predict carbohydrate-binding sites on three-dimensional (3D) protein structures. The programs search for binding sites by referring to the empirical rules derived from the known 3D structures of carbohydrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcf642b9a2f91138fe8124818d89326
https://doi.org/10.1093/protein/gzg065
https://doi.org/10.1093/protein/gzg065
Autor:
Clara Shionyu, Kazuhiro Aoki, Michiyuki Matsuda, Naoki Komatsu, Yuka Kumagai, Atsuro Sakurai, Yoshihisa Fujita
Publikováno v:
Molecular cell. 52(4)
The extracellular signal-regulated kinase (ERK) plays a central role in the signaling cascades of cell growth. Here, we show that stochastic ERK activity pulses regulate cell proliferation rates in a cell density-dependent manner. A fluorescence reso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71750ecec8c5d27d11849d8064964a11
https://pubmed.ncbi.nlm.nih.gov/24140422
https://pubmed.ncbi.nlm.nih.gov/24140422
Autor:
Takuma Shiraki, Kosuke Morikawa, Tsuyoshi Waku, Tsuyoshi Shirai, Clara Shionyu-Mitsuyama, Takuji Oyama
Publikováno v:
Protein engineering, designselection : PEDS. 24(4)
Nuclear receptors, intracellular lipid-binding proteins and metabolic enzymes are responsible for optimal metabolic homeostasis in higher organisms. Recent studies revealed the specific cooperation/competition among the subfamilies of these proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9fc175eab9039558a9a121f5c1b4db
https://pubmed.ncbi.nlm.nih.gov/21216727
https://pubmed.ncbi.nlm.nih.gov/21216727