Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Clara M. Munz"'
Autor:
Mina N. F. Morcos, Congxin Li, Clara M. Munz, Alessandro Greco, Nicole Dressel, Susanne Reinhardt, Katrin Sameith, Andreas Dahl, Nils B. Becker, Axel Roers, Thomas Höfer, Alexander Gerbaulet
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Hematopoietic stem cells produce diverse cell lineages. Here, the authors apply single-cell RNA-seq, computational integration of non-perturbative approaches for fate-mapping, and mitotic tracking to chart lineage decisions in native hematopoiesis an
Externí odkaz:
https://doaj.org/article/6dc5319467ea4f6cb5ff6f5b2c8e6b18
SummaryHematopoietic stem cells (HSCs) are the ultimate source of blood and immune cells. Under homeostatic conditions, these cells are considered a quiescent reserve population. However, it is not clear to what extent HSCs participate in emergency r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dc26dc7d83b579b279d5e202d233737
https://doi.org/10.1101/2022.10.05.510973
https://doi.org/10.1101/2022.10.05.510973
Autor:
Nicole Dressel, Loreen Natusch, Clara M. Munz, Santiago Costas Ramon, Mina N.F. Morcos, Anja Loff, Björn Hiller, Mathias Lesche, Andreas Dahl, Hella Luksch, Angela Rösen-Wolff, Axel Roers, Rayk Behrendt, Alexander Gerbaulet
Cell-intrinsic response patterns control risks arising from genome-damage, preventing malignant transformation. The DNA sensor cyclic-GMP-AMP synthase (cGAS) has emerged as a new principle detecting genome damage, as it can be triggered by aberrant s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77db08888760be211a67f0809b2cc2b5
https://doi.org/10.1101/2022.06.24.497496
https://doi.org/10.1101/2022.06.24.497496
Autor:
Diana Machado, Alexander Gerbaulet, Lars N. Royall, Clara M. Munz, Annina Denoth-Lippuner, Merit Kruse, Sebastian Jessberger, Tong Liang, Vladislav I. Korobeynyk, Baptiste N. Jaeger, Stefanie E. Chie, Kilian Buthey, Benjamin D. Simons
Publikováno v:
Cell Stem Cell
Summary The division potential of individual stem cells and the molecular consequences of successive rounds of proliferation remain largely unknown. Here, we developed an inducible cell division counter (iCOUNT) that reports cell division events in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0f0075f0b0f3746446fe1837e31ca7
https://www.repository.cam.ac.uk/handle/1810/327017
https://www.repository.cam.ac.uk/handle/1810/327017
Autor:
Alexander Gerbaulet, Morcos Mnf, Nils B. Becker, Andreas Dahl, Congxin Li, Clara M. Munz, Susanne Reinhardt, Axel Roers, Thomas Höfer, Dressel N, A. Greco
Hematopoietic stem cells (HSCs) produce a highly diverse array of cell lineages. To assay hematopoietic differentiation with minimal experimental perturbation, non-invasive methods for heritable labeling1–3 or barcoding4–7 of HSCs in vivo have re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f8a9484f62191844afae9744458c6b1
https://doi.org/10.1101/2020.08.21.261552
https://doi.org/10.1101/2020.08.21.261552
Autor:
Petter Saewen, Andreas Petzold, David Bryder, Mina Morcos, Haixia Wan, Michael D. Milsom, Thomas Zerjatke, Clara M. Munz, Alexander Gerbaulet, Natasha S Anstee, Ingmar Glauche, Ruzhica Bogeska, Susanne Reinhardt, Axel Roers, Andreas Dahl, Yan Ge
The proliferative activity of adult hematopoietic stem cells (HSCs) is controversially discussed. Inducible fluorescent histone 2B fusion protein (H2B-FP) transgenic mice are important tools for tracking the mitotic history of murine HSCs in label di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f812c17d3f7bd0bad3dde3ffd749abb1
https://doi.org/10.1101/745729
https://doi.org/10.1101/745729
Autor:
Mina Morcos, Alexander Gerbaulet, Ingmar Glauche, David Bryder, Clara M. Munz, Axel Roers, Thomas Zerjatke, Natasha S Anstee, Andreas Petzold, Michael D. Milsom, Susanne Reinhardt, Petter Säwén, Andreas Dahl, Haixia Wan, Yan Ge, Ruzhica Bogeska
Publikováno v:
The Journal of Experimental Medicine
Morcos et al. show that there is no evidence for abrupt entry of aging hematopoietic stem cells into quiescence after four divisions as previously suggested. They examine factors confounding pulse-chase experiments in H2B-fusion protein transgenic mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb7ea081bf409288196c063df19b7d8
https://pubmed.ncbi.nlm.nih.gov/32302400
https://pubmed.ncbi.nlm.nih.gov/32302400
Autor:
Mina N. F. Morcos, Congxin Li, Clara M. Munz, Alessandro Greco, Nicole Dressel, Susanne Reinhardt, Katrin Sameith, Andreas Dahl, Nils B. Becker, Axel Roers, Thomas Höfer, Alexander Gerbaulet
Publikováno v:
Nature Communications. 13(1)
Hematopoietic stem cells (HSCs) produce highly diverse cell lineages. Here, we chart native lineage pathways emanating from HSCs and define their physiological regulation by computationally integrating experimental approaches for fate mapping, mitoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3a66b3bc0f0dcbbf83b497d052f27a