Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Clara Luh"'
Autor:
Ralph Timaru-Kast, Andreas Garcia Bardon, Clara Luh, Shila P. Coronel-Castello, Phuriphong Songarj, Eva-Verena Griemert, Tobias J. Krämer, Anne Sebastiani, Ulrike Muscha Steckelings, Serge C. Thal
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Antagonism of the angiotensin II type 1 receptor (AT1) improves neurological function and reduces brain damage after experimental traumatic brain injury (TBI), which may be partly a result of enhanced indirect angiotensin II type 2 receptor
Externí odkaz:
https://doaj.org/article/e329d91b9d42476d86ee249c7dc88eb5
Autor:
Ralph Timaru-Kast, Philipp Gotthardt, Clara Luh, Changsheng Huang, Regina Hummel, Michael K. E. Schäfer, Serge C. Thal
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Traumatic brain injury (TBI) is a frequent pathology associated with poor neurological outcome in the aged population. We recently observed accelerated cerebral inflammation in aged mice in response to TBI. Candesartan is a potent specific inhibitor
Externí odkaz:
https://doaj.org/article/be32fd84710c46bd9f1680b935d799c4
Autor:
Eva-Verena Schaible, Arne Steinsträßer, Antje Jahn-Eimermacher, Clara Luh, Anne Sebastiani, Frida Kornes, Dana Pieter, Michael K Schäfer, Kristin Engelhard, Serge C Thal
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71056 (2013)
Following traumatic brain injury (TBI) neuroinflammatory processes promote neuronal cell loss. Alpha-melanocyte-stimulating hormone (α-MSH) is a neuropeptide with immunomodulatory properties, which may offer neuroprotection. Due to short half-life a
Externí odkaz:
https://doaj.org/article/d0bdcef54b31416a9e20fe992e07f880
Autor:
Ralph Timaru-Kast, Clara Luh, Philipp Gotthardt, Changsheng Huang, Michael K Schäfer, Kristin Engelhard, Serge C Thal
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43829 (2012)
After traumatic brain injury (TBI) elderly patients suffer from higher mortality rate and worse functional outcome compared to young patients. However, experimental TBI research is primarily performed in young animals. Aim of the present study was to
Externí odkaz:
https://doaj.org/article/c527921eb9924d529e9034bacb3e0a8a
Autor:
Serge C Thal, Clara Luh, Eva-Verena Schaible, Ralph Timaru-Kast, Jana Hedrich, Heiko J Luhmann, Kristin Engelhard, Christoph M Zehendner
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50752 (2012)
Disruption of the blood-brain barrier (BBB) results in cerebral edema formation, which is a major cause for high mortality after traumatic brain injury (TBI). As anesthetic care is mandatory in patients suffering from severe TBI it may be important t
Externí odkaz:
https://doaj.org/article/60377b5fe82744568c1728af48d3ae2c
Autor:
Clara Luh, Katharina Gierth, Ralph Timaru-Kast, Kristin Engelhard, Christian Werner, Serge C Thal
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19948 (2011)
It is unclear whether a single, brief, 15-minute episode of background anesthesia already modulates delayed secondary processes after experimental brain injury. Therefore, this study was designed to characterize three anesthesia protocols for their e
Externí odkaz:
https://doaj.org/article/019075fa757f42d2b4495cef40b63dd0
Autor:
Christian Werner, Konstantin Radyushkin, Bernd Moosmann, Clara Luh, Serge C. Thal, Anja Ditter, Matthias Granold, Anne Sebastiani, Bruno Pöttker, Ralph Timaru-Kast, Kristin Engelhard, Eva-Verena Schaible, Christina Gölz, Philipp G. Sebastiani, Michael K. E. Schäfer
Publikováno v:
Critical Care Medicine. 44:e70-e82
Objectives:The gamma-aminobutyric acid modulator propofol induces neuronal cell death in healthy immature brains by unbalancing neurotrophin homeostasis via p75 neurotrophin receptor signaling. In adulthood, p75 neurotrophin receptor becomes down-reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aea82c6461f134b797edcb0cbad85a3
https://doi.org/10.1097/ccm.0000000000001284
https://doi.org/10.1097/ccm.0000000000001284
Publikováno v:
Journal of Neurotrauma. 32:1777-1788
To prevent methodological errors of quantitative PCR (qPCR) normalization with reference genes is obligatory. Although known to influence gene expression, impact of age on housekeeping gene expression has not been determined after acute brain lesions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b0420564d8872bd4ea982c94738bee
https://doi.org/10.1089/neu.2014.3784
https://doi.org/10.1089/neu.2014.3784
Autor:
R. Dickinson, Scott P. Armstrong, Kristin Engelhard, Anne Sebastiani, Tobias Hirnet, Serge C. Thal, Rita Campos-Pires, Konstantin Radyushkin, Clara Luh, Nicholas P. Franks, Christian Werner, Marco Gruss
Publikováno v:
Critical Care Medicine. 43:149-158
Objectives: To determine the neuroprotective efficacy of the inert gas xenon following traumatic brain injury and to determine whether application of xenon has a clinically relevant therapeutic time window. Design: Controlled animal study. Setting: U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3730f3a09a0a4d573ac3b5c7af8ae478
https://doi.org/10.1097/ccm.0000000000000624
https://doi.org/10.1097/ccm.0000000000000624
Autor:
Clara Luh, Serge C. Thal, Simon Meyer, Sergej Feiler, Axel Neulen, Katrin Frauenknecht, Lubomir T. Lubomirov
Publikováno v:
Translational Stroke Research
Development of vasogenic brain edema is a key event contributing to mortality after subarachnoid hemorrhage (SAH). The precise underlying mechanisms at the neurovascular level that lead to disruption of the blood-brain barrier (BBB) are still unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a5dfb181e3937a75726f921f5278a0
https://pubmed.ncbi.nlm.nih.gov/30467816
https://pubmed.ncbi.nlm.nih.gov/30467816